5 Questions
What is the key determinant of mRNA longevity in the cytoplasm?
The untranslated region (3'UTR)
How does the AU-rich region in the 3'UTR affect mRNA half-life?
It stimulates the removal of the poly(A) tail, causing fast degradation.
What happens when an AT-rich 3'UTR gene is inserted into the B-globin gene?
The resulting globin message has a shorter half-life.
How does the hormone prolactin affect the longevity of specific mRNA?
It increases the longevity of casein mRNA significantly.
What is the consequence of the base pairing between the AU-rich region and the poly(A) tail?
The double-stranded stem is snipped off, leading to degradation.
Test your knowledge on genes and the splicing process. Explore the importance of consensus sequences at intron-exon junctions and branch sites for correct splicing. Learn how gene mutations can lead to disorders.
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