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Questions and Answers
What is the key determinant of mRNA longevity in the cytoplasm?
What is the key determinant of mRNA longevity in the cytoplasm?
The untranslated region (3'UTR)
How does the AU-rich region in the 3'UTR affect mRNA half-life?
How does the AU-rich region in the 3'UTR affect mRNA half-life?
It stimulates the removal of the poly(A) tail, causing fast degradation.
What happens when an AT-rich 3'UTR gene is inserted into the B-globin gene?
What happens when an AT-rich 3'UTR gene is inserted into the B-globin gene?
The resulting globin message has a shorter half-life.
How does the hormone prolactin affect the longevity of specific mRNA?
How does the hormone prolactin affect the longevity of specific mRNA?
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What is the consequence of the base pairing between the AU-rich region and the poly(A) tail?
What is the consequence of the base pairing between the AU-rich region and the poly(A) tail?
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