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Questions and Answers

What is the primary significance of the prolonged duration of a cardiac contractile cell action potential?

  • Prevents tetanus and allows time for ventricular filling (correct)
  • Increases heart rate significantly
  • Allows rapid firing of the heart
  • Enhances electrical conductivity in the heart

Which event corresponds to the QRS complex in the ECG during a single heartbeat?

  • Atrial contraction
  • Atrial depolarization
  • SA nodal action potential
  • Ventricular contraction (correct)

During which phase of the cardiac cycle does the end-diastolic volume (EDV) occur?

  • Ventricular filling (correct)
  • Isovolumetric relaxation
  • Isovolumetric contraction
  • Ejection

What defines a septal defect in the heart?

<p>An abnormal opening in the septum separating heart chambers (B)</p> Signup and view all the answers

What occurs during the isovolumetric relaxation phase of the cardiac cycle?

<p>All heart valves are closed, and pressure drops (C)</p> Signup and view all the answers

Which of the following best describes the term 'stroke volume'?

<p>Amount of blood ejected by the heart with each beat (B)</p> Signup and view all the answers

What is indicated by a dicrotic notch in the arterial pressure waveform?

<p>End of systole (D)</p> Signup and view all the answers

Which phase follows the atrial contractile cell action potential during a heartbeat?

<p>Ventricular contractile cell action potential (A)</p> Signup and view all the answers

What is the primary role of the diaphragm during quiet, resting inhalation?

<p>To descend and increase thoracic cavity depth (A)</p> Signup and view all the answers

Which muscles are involved in forced exhalation?

<p>Internal intercostals and rectus abdominis (B)</p> Signup and view all the answers

How is functional residual capacity (FRC) defined?

<p>Volume of air remaining in the lungs at the end of a quiet exhale (C)</p> Signup and view all the answers

What is the transmural pressure calculated as during the FRC phase?

<p>Pin - Pout (C)</p> Signup and view all the answers

At functional residual capacity (FRC), what is true about the relationship between atmospheric pressure and alveolar pressure?

<p>Patm = Palv (B)</p> Signup and view all the answers

What pressure is indicated by Pip at FRC?

<p>-4 mmHg (A)</p> Signup and view all the answers

During exhalation, which muscle action is performed by the rectus abdominis?

<p>Depresses the lower ribs (B)</p> Signup and view all the answers

Which condition describes the presence of air in the pleural space leading to lung collapse?

<p>Pneumothorax (A)</p> Signup and view all the answers

What does the 1st heart sound 'lub' indicate during the cardiac cycle?

<p>Closure of AV valves (D)</p> Signup and view all the answers

How is stroke volume (SV) calculated?

<p>SV = EDV - ESV (A)</p> Signup and view all the answers

During the isovolumetric ventricular relaxation phase, what happens to the pressure in the ventricles compared to the aorta?

<p>Pressure in ventricles is less than in aorta (D)</p> Signup and view all the answers

What is the typical stroke volume at rest?

<p>70 mL (B)</p> Signup and view all the answers

What does the 2nd heart sound 'dup' signify in the cardiac cycle?

<p>Closure of SL valves (A)</p> Signup and view all the answers

What is stenosis in relation to heart valve defects?

<p>Narrowing of a valve that restricts blood flow (A)</p> Signup and view all the answers

What is a key difference between the systemic and pulmonary circulations?

<p>Systemic circulation supplies oxygenated blood, while pulmonary involves oxygen exchange (C)</p> Signup and view all the answers

What determines the opening and closing of all heart valves?

<p>Volumetric changes and pressure differences (A)</p> Signup and view all the answers

What initiates the contraction of muscle fibers?

<p>Elevated cytosolic Ca2+ (B)</p> Signup and view all the answers

What role do the ventricular papillary muscles play during ventricular systole?

<p>They prevent backward flow of blood (A)</p> Signup and view all the answers

How is blood in a typical healthy individual primarily composed?

<p>One third hematocrit and two thirds interstitial fluid (C)</p> Signup and view all the answers

Which statement about sickle-cell disease or trait is correct?

<p>Low oxygen levels benefit individuals with this condition (D)</p> Signup and view all the answers

Which of the following factors would decrease blood flow the most?

<p>Increase in peripheral resistance (B)</p> Signup and view all the answers

What is the role of capillary hydrostatic pressure (Pc) in bulk flow?

<p>It contributes to the pressure exerted by blood against capillary walls. (A)</p> Signup and view all the answers

Which of the following is NOT a Starling force that determines bulk flow?

<p>Venous return pressure (Pv) (A)</p> Signup and view all the answers

What happens when the net filtration pressure (NFP) is negative?

<p>Fluid is primarily reabsorbed into capillaries. (B)</p> Signup and view all the answers

What is the primary function of the lymphatic system in relation to bulk flow?

<p>It absorbs excess filtrate and proteins that escape from capillaries. (C)</p> Signup and view all the answers

Which statement about filtration and absorption is accurate?

<p>Filtration is the movement of fluid out of the blood, while absorption is the movement of fluid into the blood. (B)</p> Signup and view all the answers

What is the effect of sympathetic stimulation on the action potential upstroke in AV node cells?

<p>Increases L-type Ca2+ current (D)</p> Signup and view all the answers

How does the Frank-Starling mechanism help in balancing left and right ventricular output?

<p>Prevents pooling of blood in one circuit (A)</p> Signup and view all the answers

What is the primary consequence of decreased L-type Ca2+ current due to parasympathetic stimulation?

<p>Slower conduction velocity (C)</p> Signup and view all the answers

Which term describes the resistance the heart must overcome to eject blood during contraction?

<p>Afterload (A)</p> Signup and view all the answers

In what way does the ventricular-function curve differ from the length-tension relationship in skeletal muscle?

<p>Cardiac muscle typically operates well below optimal resting length (A)</p> Signup and view all the answers

What is an expected consequence of increased end-diastolic volume (EDV) on stroke volume according to the Frank-Starling mechanism?

<p>Increased stroke volume due to enhanced myocardial tension (C)</p> Signup and view all the answers

What role do neurohormones primarily play in altering cardiac function?

<p>They change ion channel behavior in nodal cells (B)</p> Signup and view all the answers

What is the ejection fraction (EF)?

<p>The percentage of blood ejected from the ventricles during systole (C)</p> Signup and view all the answers

Flashcards

Systole

Phase of the cardiac cycle where the ventricles contract, increasing pressure and causing the "lub" sound.

Ventricular Ejection

Phase of systole where blood is pumped out of the ventricles into the aorta and pulmonary artery.

Stroke Volume (SV)

Volume of blood pumped from each ventricle per beat.

End-Diastolic Volume (EDV)

Volume of blood in the ventricle at the end of diastole (relaxation).

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End-Systolic Volume (ESV)

Volume of blood remaining in the ventricle after ejection.

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Isovolumetric Ventricular Relaxation

Phase of the cardiac cycle where the ventricles relax, but the volume remains constant.

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Wiggers Diagram

Graphical representation of the electrical, pressure, and mechanical events of a cardiac cycle.

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Heart Valve Stenosis

Valve opening is narrowed, restricting blood flow.

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Heart Valve Insufficiency

Valve doesn't close completely, allowing blood to leak backward.

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Cardiac Cycle

All events related to the heart's activity during one complete contraction and relaxation.

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Pulmonary Circulation

Blood flow between the heart and lungs.

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Systemic Circulation

Blood flow between the heart and the rest of the body.

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1st Heart Sound

Occurs when AV valves close.

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2nd Heart Sound

Occurs when SL valves close.

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Cardiac Contractile Cell Action Potential Duration

The prolonged duration of a cardiac contractile cell action potential prevents tetanus (sustained contraction), allowing time for ventricular filling.

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ECG P Wave

The P wave on an ECG corresponds to atrial depolarization (electrical signal causing atrial contraction).

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SA Nodal Action Potential

The SA node's action potential initiates the heartbeat.

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Atrial Contractile Cell AP

Atrial contractile cell action potential is the electrical signal causing atrial contraction.

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QRS Complex (ECG)

The QRS complex on an ECG indicates ventricular depolarization (electrical signal starting ventricular contraction).

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Ventricular Contractile Cell AP

The action potential in ventricular contractile cells triggers ventricular contraction.

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ECG T Wave

The T wave on the ECG corresponds to ventricular repolarization (recharging the ventricles).

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Cardiac Cycle Phases

The four phases include ventricular filling (diastole), isovolumetric contraction (systole), ejection (systole), and isovolumetric relaxation (diastole).

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Ventricular Filling (Cardiac Cycle)

During ventricular filling (diastole), blood flows into the ventricles.

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Isovolumetric Contraction

Isovolumetric contraction (systole) is when the ventricles contract but no blood is ejected yet; volume remains the same.

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Ejection (Cardiac Cycle)

Blood is ejected from the ventricles during the ejection phase (systole).

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Isovolumetric Relaxation

During isovolumetric relaxation (diastole), the ventricles are relaxing, but volume doesn't change yet.

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End-Diastolic Volume (EDV)

The final volume of blood in the ventricles after filling.

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End-Systolic Volume (ESV)

Volume of blood remaining in the ventricles after contraction.

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Sympathetic innervation effect on AV node

Sympathetic stimulation increases the L-type Ca2+ current in AV node cells, increasing conduction velocity.

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Parasympathetic innervation effect on AV node

Parasympathetic stimulation decreases the L-type Ca2+ current in AV node cells, decreasing conduction velocity.

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Frank-Starling Mechanism

More venous return (preload) leads to increased ventricular stretch, stronger contraction, and increased stroke volume.

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Frank-Starling Mechanism implications

Maintains a balance between left and right ventricle output, prevents a rise in end-systolic volume, and prevents a rise in venous pressure.

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Afterload

Resistance the heart must overcome to eject blood.

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Contractility

Ability of heart muscle to contract.

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Ejection Fraction

Percentage of blood ejected from ventricles during systole.

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Inotropic Effects

Alterations in heart's contractility.

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Diffusion (across conc gradients)

The movement of molecules from an area of higher concentration to an area of lower concentration.

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Bulk Flow

The overall movement of fluid, a result of filtration and absorption, driven by pressure gradients.

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Filtration (bulk flow)

Movement of fluid out of the blood due to a pressure difference.

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Absorption (bulk flow)

Movement of fluid into the blood due to a pressure difference.

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Starling forces

The four pressures (capillary hydrostatic, interstitial fluid hydrostatic, plasma osmotic, and interstitial fluid osmotic) that determine the net filtration pressure.

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Capillary hydrostatic pressure (Pc)

Pressure exerted by blood against capillary walls.

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Interstitial fluid hydrostatic pressure (Pif)

The pressure of interstitial fluid, opposing filtration.

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Osmotic force due to ISF protein concentration (Ï€if)

The osmotic pressure pulling fluid out of the capillaries due to proteins in interstitial fluid.

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Osmotic force due to plasma protein concentration (Ï€c)

The osmotic pressure pulling fluid into the capillaries, related to proteins in the blood.

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Net Filtration Pressure (NFP)

The difference between the pressures promoting filtration and those promoting reabsorption.

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Lymphatic system

Returns excess fluid and leaked proteins from the interstitial spaces to the bloodstream

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ATP role in force generation

ATP provides energy for muscle contraction, powering the force generation process.

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Desmosomes/Gap junctions

Desmosomes provide strong cell-cell adhesion, while gap junctions allow direct cytoplasmic communication between cells.

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Ca2+ and contraction

Increased cytosolic calcium triggers muscle contraction by binding to regulatory proteins.

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Negative resting membrane potential

The difference in electrical charge across the cell membrane when the cell is at rest.

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Sliding filament model

Muscle contraction is caused by the sliding of actin and myosin filaments.

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Ventricular papillary muscles contraction time

Papillary muscle contraction occurs concurrently with atrial contraction, closing the AV valves and preventing backflow during ventricular systole.

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Blood composition (general)

Blood is primarily extracellular fluid with dissolved solutes, containing red blood cells, white blood cells, platelets, and proteins, supporting gas transport, clotting, and defense.

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Sickle-cell trait/disease benefit

Heterozygotes for sickle-cell gene have increased resistance to malaria.

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Factor decreasing blood flow

Factors that decrease blood flow include narrowing of blood vessels, increased blood viscosity, or a significant decrease in blood pressure.

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Quiet Inhalation Muscles

Sternocleidomastoid elevates the sternum; Scalenes fix or elevate ribs 1-2; External intercostals elevate ribs 2-12, widening the thoracic cavity; and Diaphragm descends, increasing thoracic cavity depth during inhalation.

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Quiet Exhalation

Quiet exhalation requires no muscle contractions; it happens passively as the chest wall recoils.

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Forced Exhalation Muscles

Internal intercostals (interosseous part) depress ribs 1-11, narrowing the thoracic cavity; Diaphragm ascends, decreasing thoracic cavity depth; and Rectus abdominis and external abdominal obliques compress abdominal organs, pushing the diaphragm upward.

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Functional Residual Capacity (FRC)

The volume of air remaining in the lungs at the end of a quiet exhale when respiratory muscles are relaxed.

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Transmural Pressure

The difference in pressure across a structure, such as the lung or chest wall.

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Transpulmonary Pressure (Ptp)

The pressure difference between the alveolar pressure and the intrapleural pressure.

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Chest Wall Pressure (Pcw)

The pressure difference between the intrapleural pressure and atmospheric pressure.

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Atmospheric Pressure (Patm)

The pressure exerted by the atmosphere.

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Alveolar Pressure (Palv)

The pressure inside the alveoli.

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Intrapleural Pressure (Pip)

The pressure within the pleural cavity.

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Pneumothorax

A condition where air enters the pleural space, causing lung collapse.

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Atelectasis

Collapse of a lung or part of a lung.

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Study Notes

General Study Notes

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