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Questions and Answers

What physiological function does the hypothalamus perform to maintain fluid balance?

  • Increases heart rate and releases cortisol
  • Triggers lymphatic drainage and releases norepinephrine
  • Stimulates thirst and releases ADH (correct)
  • Stimulates hunger and releases insulin

Which system is activated by the kidneys in response to low blood pressure to regulate fluid balance?

  • Parasympathetic Nervous System
  • Sympathetic Nervous System
  • Renin-Angiotensin Aldosterone System (RAAS) (correct)
  • Endocrine Feedback Loop

How do baroreceptors contribute to fluid balance in the body?

  • They increase thirst when blood is diluted.
  • They regulate electrolyte levels directly within the kidneys.
  • They detect blood pressure changes and signal for fluid retention or excretion. (correct)
  • They stimulate the hunger sensation for energy replenishment.

What occurs in the body when dehydration is detected?

<p>The hypothalamus triggers thirst and releases ADH. (C)</p> Signup and view all the answers

Which electrolyte's normal ranges are crucial for maintaining fluid homeostasis?

<p>Sodium (C)</p> Signup and view all the answers

What is the effect of nicotinic receptors in target organs or tissues?

<p>Causes muscle contraction or nerve signal transmission (D)</p> Signup and view all the answers

Which neurotransmitter primarily activates muscarinic receptors?

<p>Acetylcholine (D)</p> Signup and view all the answers

What is the primary effect of alpha-1 adrenergic receptors?

<p>Vasoconstriction and increased blood pressure (B)</p> Signup and view all the answers

Where are muscarinic receptors primarily located?

<p>Smooth muscles and glands (A)</p> Signup and view all the answers

What effect does the activation of M2 muscarinic receptors have on the heart?

<p>Slows heart rate (A)</p> Signup and view all the answers

What role do ligand-gated ion channels play in cellular function?

<p>Allow ions to enter the cell (B)</p> Signup and view all the answers

How do intracellular receptors affect gene expression?

<p>They change gene activity after the ligand enters the cell (B)</p> Signup and view all the answers

Which statement about GPCRs is true?

<p>They activate secondary messengers inside the cell (C)</p> Signup and view all the answers

What is the primary role of absorption in pharmacokinetics?

<p>Drug moves from site of administration to systemic circulation. (D)</p> Signup and view all the answers

Which factor does NOT influence drug absorption?

<p>Distribution effectiveness (C)</p> Signup and view all the answers

How does the body's condition like food in the stomach affect drug absorption?

<p>It can interfere with drug dissolution and absorption. (B)</p> Signup and view all the answers

What is the main effect of P-glycoprotein (Pgp) on drug absorption?

<p>It can pump drugs out of cells, reducing absorption. (D)</p> Signup and view all the answers

Which of the following statements about distribution in pharmacokinetics is correct?

<p>Distribution is affected by drug characteristics and the body's ability to cross membranes. (A)</p> Signup and view all the answers

What role does surface area in the intestines play in drug absorption?

<p>It enhances absorption due to increased contact time. (A)</p> Signup and view all the answers

Which route of drug administration is likely to provide the fastest absorption?

<p>Intravenous injection (D)</p> Signup and view all the answers

What is the end goal of the pharmacokinetic processes?

<p>To provide therapeutic effect in tissues. (D)</p> Signup and view all the answers

What is the main characteristic of acute pain?

<p>Localized pain that lasts less than 3 months (B)</p> Signup and view all the answers

Which treatment is commonly used for chronic pain management?

<p>Multimodal therapies including physical therapy and antidepressants (D)</p> Signup and view all the answers

How does neuropathic pain primarily differ from acute pain?

<p>Neuropathic pain is a persistent issue caused by nervous system changes (B)</p> Signup and view all the answers

What is a common symptom associated with acute pain?

<p>Increased heart rate and blood pressure (D)</p> Signup and view all the answers

Which type of pain is illustrated by low back pain in conditions like fibromyalgia?

<p>Chronic pain (C)</p> Signup and view all the answers

What is the primary role of sodium (Na⁺) in the body?

<p>Regulating fluid balance and blood pressure (C)</p> Signup and view all the answers

Which electrolyte is considered the main intracellular cation?

<p>Potassium (K⁺) (D)</p> Signup and view all the answers

What is the normal range for calcium (Ca²⁺) in blood?

<p>9-10.5 mg/dL (B)</p> Signup and view all the answers

How do bicarbonate and carbonic acid work together to regulate pH?

<p>Carbonic acid releases H⁺ to raise pH (D)</p> Signup and view all the answers

What does the respiratory buffering system do when blood pH is too acidic?

<p>Increases breathing rate to expel CO₂ (B)</p> Signup and view all the answers

Which of the following is NOT a function of magnesium (Mg²⁺)?

<p>Bone formation (C)</p> Signup and view all the answers

What is the role of phosphate (PO₄³⁻) in the body?

<p>Energy production and metabolism (D)</p> Signup and view all the answers

What is the typical normal range for potassium (K⁺) in the blood?

<p>3.5-5.0 mEq/L (D)</p> Signup and view all the answers

What is the primary role of serotonin in the body?

<p>Mood regulation and controlling appetite (B)</p> Signup and view all the answers

What hormone is known as the 'Love Hormone'?

<p>Oxytocin (B)</p> Signup and view all the answers

Which neurotransmitter is mainly involved in the sleep-wake cycle and low levels are linked to depression?

<p>Serotonin (D)</p> Signup and view all the answers

Which hormone is crucial for maintaining high levels of progesterone and estrogen during early pregnancy?

<p>hCG (B)</p> Signup and view all the answers

What is a primary function of Nitric Oxide in the body?

<p>Vasodilation (A)</p> Signup and view all the answers

Which hormone is specifically involved in the prevention of premature labor?

<p>Progesterone (B)</p> Signup and view all the answers

Which of the following is a characteristic of Norepinephrine?

<p>Nudges you into action and focuses attention (C)</p> Signup and view all the answers

How is the placenta formed during pregnancy?

<p>From trophoblast cells after blastocyst implantation (C)</p> Signup and view all the answers

Substance P is primarily associated with which of the following functions?

<p>Pain transmission (D)</p> Signup and view all the answers

Why are low levels of Norepinephrine linked to depression?

<p>It diminishes arousal and focus (B)</p> Signup and view all the answers

Flashcards

Ligand-gated ion channels

Membrane proteins that open or close in response to a ligand (a signaling molecule), allowing ions to pass through.

GPCRs (G-protein coupled receptors)

Membrane proteins that activate intracellular signaling pathways (secondary messengers) in response to a ligand.

Enzyme-linked receptors

Membrane proteins that activate enzymes inside the cell after ligand binding, often leading to cellular responses.

Intracellular receptors

Receptors located inside the cell, that bind ligands and regulate gene expression.

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Nicotinic receptors

Cholinergic receptors that induce ion channel opening, leading to muscle contractions or nerve transmission, found in skeletal muscle and autonomic ganglia.

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Muscarinic receptors

Cholinergic receptors that activate intracellular pathways, affecting smooth muscle, glands, and the heart.

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Alpha-1 adrenergic receptors

Receptors that are activated by norepinephrine and epinephrine, regulating blood vessel constriction and blood pressure.

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Parasympathetic Nervous System

Branch of the autonomic nervous system that promotes "rest and digest" functions.

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Absorption

The movement of a drug from the site of administration to the systemic circulation.

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Factors affecting Absorption

Drug form, characteristics, body conditions (food, blood flow), transport mechanisms (P-glycoprotein), and time factors (diarrhea).

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Distribution

The movement of a drug from the systemic circulation to the tissues.

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Factors affecting Distribution

Drug characteristics (size, charge, membrane permeability) and body characteristics (membrane properties).

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Pharmacokinetic processes

The processes by which drugs are absorbed, distributed, metabolized, and eliminated from the body.

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ADME

Acronym for the four key pharmacokinetic processes (Absorption, Distribution, Metabolism, Excretion) of a drug.

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Ointments

A topical medication form that tends to have minimal systemic absorption, often slower penetration.

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Topical Medications

Medications applied directly to the body surface, like skin, not intended for systemic absorption.

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Fluid Balance Control

The body regulates fluid levels through mechanisms like thirst, ADH release, the RAAS system, and baroreceptor feedback.

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Hypothalamus Role

The hypothalamus triggers thirst and releases ADH (antidiuretic hormone) when dehydration occurs, promoting water reabsorption by the kidneys.

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RAAS (Renin-Angiotensin Aldosterone System)

The RAAS system activates when blood pressure drops. It causes the kidneys to reabsorb sodium and water, raising blood pressure and fluid retention.

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Baroreceptor Function

Baroreceptors in the heart and kidneys sense changes in blood pressure. They signal the body to either retain or excrete fluids.

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Fluid Balance: Key Players

The body monitors blood concentration and volume to maintain fluid balance. The hypothalamus, ADH, RAAS, and baroreceptors are critical for this process.

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Histamine's role

Histamine is a chemical messenger involved in the immune response and allergic reactions. It triggers inflammation and other responses.

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Norepinephrine function

Norepinephrine is a neurotransmitter associated with arousal, focus, and the fight-or-flight response. It can also affect appetite and mood.

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Serotonin's effects

Serotonin is a neurotransmitter crucial for mood regulation, sleep, and appetite. Low levels can lead to depression and anxiety.

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Oxytocin function

Oxytocin is a hormone that promotes bonding and is involved in social behaviors, childbirth, and lactation. It plays a role in emotional connections.

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Substance P function

Substance P is a neuropeptide involved in pain signals. It's linked to chronic pain conditions like migraines.

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hCG function

Human chorionic gonadotropin (hCG) is a hormone produced by the embryo and placenta. It helps maintain the corpus luteum, crucial for early pregnancy.

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Estrogen's role in pregnancy

Estrogen, produced by the corpus luteum and placenta, promotes growth of the uterus, breasts, and genitalia during pregnancy.

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Progesterone's role in pregnancy

Progesterone, produced by the corpus luteum and placenta, supports early embryo nutrition and prevents premature labor by relaxing the uterus.

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Placenta formation

The placenta develops from the trophoblast cells of the blastocyst after implantation in the endometrium.

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Nitric Oxide's role

Nitric oxide is involved in vasodilation (widening of blood vessels), neurotransmission and memory.

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Oncotic Pressure

The force exerted by proteins (like albumin) in the blood that pulls water back into capillaries from the interstitial space.

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Filtration

The process by which fluid, solutes, and small proteins are pushed out of capillaries into the interstitial space, driven by hydrostatic pressure.

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Sodium (Na⁺) Role

Sodium is the main cation in the extracellular fluid. It regulates fluid balance, blood pressure, and nerve function.

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Potassium (K⁺) Role

Potassium is the primary intracellular cation, essential for nerve impulses, muscle contractions, and maintaining cell function.

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Calcium (Ca²⁺) Role

Calcium is critical for strong bones, muscle contraction, blood clotting, and nerve signaling.

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Magnesium (Mg²⁺) Role

Magnesium is essential for enzyme function, muscle relaxation, and maintaining a normal heart rhythm.

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Phosphate (PO₄³⁻) Role

Phosphate plays a role in energy production (ATP), bone health, and cellular metabolism.

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Endogenous Opioids

Naturally occurring chemicals in the body, like endorphins and enkephalins, that reduce pain by blocking pain signals. They are similar to morphine in their effects.

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Acute Pain

Short-term pain lasting less than 3 months, typically caused by tissue injury and characterized by sharp, localized pain.

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Chronic Pain

Long-term pain lasting over 3 months, often caused by changes in the nervous system and characterized by dull, persistent pain.

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Neuropathic Pain

Pain caused by damage to nerves, resulting in tingling, burning, or shooting sensations.

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Referred Pain

Pain felt in a different location from the source of the injury, often due to shared nerve pathways.

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