40 Questions
Which type of hypersensitivity reaction involves antibodies of the IgG and IgM classes?
Type II hypersensitivity
What is the mechanism of type III hypersensitivity reaction?
Antibodies combine with the antigen, leading to immune complex formation
Which condition is an example of type II hypersensitivity?
Incompatible blood transfusion
What is an example of a condition caused by type III hypersensitivity reaction?
Acute proliferative post-streptococcal glomerulonephritis
Which type of hypersensitivity reaction involves complement activation?
Type II hypersensitivity
What is an example of an immune complex reaction caused by type III hypersensitivity?
Serum sickness
Which type of hypersensitivity reaction involves antibodies combining with the antigen producing immune complexes trapped within vascular basement membranes?
Type III hypersensitivity
What type of reaction involves repeated subcutaneous injection of antigens producing local vasculitis, necrosis, and edema?
Arthus reaction
What happens in type II hypersensitivity when the antigen is a component of a cell membrane?
The target cells undergo lysis
What is an example of a condition caused by type II hypersensitivity involving autoimmune destruction of red blood cells?
Incompatible blood transfusion
Which type of hypersensitivity is characterized by the antigen stimulating T lymphocytes and causing cell-mediated immunity?
Type IV hypersensitivity
What is the hallmark of collagen diseases (connective tissue diseases)?
Systemic fibrosis affecting multiple organs
Which autoimmune disease is characterized by injury of collagen within and around vessels?
Scleroderma
Which condition results from altered tissue antigenicity due to the actions of microorganisms or drugs?
Rheumatic fever
What is the common feature of endocrine diseases such as Hashimoto's thyroiditis and autoimmune hemolytic anemia?
Destruction of body tissues by autoantibodies
What is an example of a type IV hypersensitivity reaction?
Contact dermatitis
What is the mechanism of immune complex formation in autoimmune diseases like SLE?
Loss of tolerance leading to tissue destruction
"Immunodeficiency" involves a deficient response that may affect:
'B or T lymphocytes, macrophages , complement'
"Loss of tolerance" in autoimmunity refers to:
'Self' proteins being mistakenly recognized as foreign
"Cross reactions" can occur between:
'Self' structures and certain microbes
Which type of hypersensitivity reaction requires complement activation and leads to lysis of target cells?
Type II hypersensitivity
What is an example of a condition caused by Type III hypersensitivity reaction?
Acute proliferative post-streptococcal glomerulonephritis
What is the mechanism of immune complex formation in Type III hypersensitivity?
The antibodies combining with the antigen producing immune complexes trapped within vascular basement membranes
Which autoimmune disease is characterized by injury of collagen within and around vessels?
Polyarteritis nodosa
What happens in Type II hypersensitivity when the antigen is a component of a cell membrane?
The target cells undergo lysis
What is the hallmark of collagen diseases?
Fibrinoid necrosis
In which autoimmune disease is systemic fibrosis known to affect the skin, GIT, lung, myocardium & kidneys?
Scleroderma
What mechanism may lead to altered tissue antigenicity in autoimmune diseases?
Cross reactions between human structures and certain microbes
Which condition results from loss of tolerance where normal tissue components are considered antigenic, leading to tissue destruction & disease development?
Contact dermatitis
What type of hypersensitivity reaction involves cell-mediated graft rejection and caseous necrosis in tuberculosis?
Type IV hypersensitivity
What is the mechanism of immune complex formation in Type III hypersensitivity?
Complement activation
Which autoimmune disease is characterized by systemic fibrosis affecting skin, GIT, lung, myocardium & kidneys?
Scleroderma
What happens in Type II hypersensitivity when the antigen is a component of a cell membrane?
Antibodies combine with the antigen producing immune complexes trapped within vascular basement membranes
In which autoimmune disease is Hashimoto's thyroiditis an example?
Systemic lupus erythematosus (SLE)
What type of reaction involves repeated subcutaneous injection of antigens producing local vasculitis, necrosis, and edema?
Type IV hypersensitivity
What type of hypersensitivity reaction involves the antibodies (IgG and IgM) combining with the antigen producing immune complexes trapped within vascular basement membranes?
Type III
Which condition results from loss of tolerance where normal tissue components are considered antigenic, leading to tissue destruction and disease development?
Hashimoto's thyroiditis
What happens in Type II hypersensitivity when the antigen is a component of a cell membrane?
The target cells undergo lysis
What is an example of a condition caused by Type III hypersensitivity reaction?
Acute Proliferative Post-Streptococcal Glomerulonephritis
Which autoimmune disease is characterized by injury of collagen within and around vessels?
Scleroderma
Test your understanding of disorders of immune reaction, with a focus on type II hypersensitivity (cytotoxic hypersensitivity) and its mechanisms. Explore examples such as incompatible blood transfusion and Rh incompatibility.
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