General Pathology-2: Disorders of Immune Reaction Quiz
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Questions and Answers

Which type of hypersensitivity reaction involves antibodies of the IgG and IgM classes?

  • Type II hypersensitivity (correct)
  • Type I hypersensitivity
  • Type IV hypersensitivity
  • Type III hypersensitivity

    • What is the mechanism of type III hypersensitivity reaction?

  • Antigen directly causes lysis of target cells
  • T cells directly attack self-antigens
  • Antibodies combine with the antigen, leading to immune complex formation (correct)
  • Antibodies attach to mast cells and basophils, leading to degranulation

    • Which condition is an example of type II hypersensitivity?

  • Systemic lupus erythematosus
  • Incompatible blood transfusion (correct)
  • Rheumatoid arthritis
  • Type 1 diabetes mellitus

    • What is an example of a condition caused by type III hypersensitivity reaction?

    <p>Acute proliferative post-streptococcal glomerulonephritis</p> Signup and view all the answers

    Which type of hypersensitivity reaction involves complement activation?

    <p>Type II hypersensitivity</p> Signup and view all the answers

    What is an example of an immune complex reaction caused by type III hypersensitivity?

    <p>Serum sickness</p> Signup and view all the answers

    Which type of hypersensitivity reaction involves antibodies combining with the antigen producing immune complexes trapped within vascular basement membranes?

    <p>Type III hypersensitivity</p> Signup and view all the answers

    What type of reaction involves repeated subcutaneous injection of antigens producing local vasculitis, necrosis, and edema?

    <p>Arthus reaction</p> Signup and view all the answers

    What happens in type II hypersensitivity when the antigen is a component of a cell membrane?

    <p>The target cells undergo lysis</p> Signup and view all the answers

    What is an example of a condition caused by type II hypersensitivity involving autoimmune destruction of red blood cells?

    <p>Incompatible blood transfusion</p> Signup and view all the answers

    Which type of hypersensitivity is characterized by the antigen stimulating T lymphocytes and causing cell-mediated immunity?

    <p>Type IV hypersensitivity</p> Signup and view all the answers

    What is the hallmark of collagen diseases (connective tissue diseases)?

    <p>Systemic fibrosis affecting multiple organs</p> Signup and view all the answers

    Which autoimmune disease is characterized by injury of collagen within and around vessels?

    <p>Scleroderma</p> Signup and view all the answers

    Which condition results from altered tissue antigenicity due to the actions of microorganisms or drugs?

    <p>Rheumatic fever</p> Signup and view all the answers

    What is the common feature of endocrine diseases such as Hashimoto's thyroiditis and autoimmune hemolytic anemia?

    <p>Destruction of body tissues by autoantibodies</p> Signup and view all the answers

    What is an example of a type IV hypersensitivity reaction?

    <p>Contact dermatitis</p> Signup and view all the answers

    What is the mechanism of immune complex formation in autoimmune diseases like SLE?

    <p>Loss of tolerance leading to tissue destruction</p> Signup and view all the answers

    "Immunodeficiency" involves a deficient response that may affect:

    <p>'B or T lymphocytes, macrophages , complement'</p> Signup and view all the answers

    "Loss of tolerance" in autoimmunity refers to:

    <p>'Self' proteins being mistakenly recognized as foreign</p> Signup and view all the answers

    "Cross reactions" can occur between:

    <p>'Self' structures and certain microbes</p> Signup and view all the answers

    Which type of hypersensitivity reaction requires complement activation and leads to lysis of target cells?

    <p>Type II hypersensitivity</p> Signup and view all the answers

    What is an example of a condition caused by Type III hypersensitivity reaction?

    <p>Acute proliferative post-streptococcal glomerulonephritis</p> Signup and view all the answers

    What is the mechanism of immune complex formation in Type III hypersensitivity?

    <p>The antibodies combining with the antigen producing immune complexes trapped within vascular basement membranes</p> Signup and view all the answers

    Which autoimmune disease is characterized by injury of collagen within and around vessels?

    <p>Polyarteritis nodosa</p> Signup and view all the answers

    What happens in Type II hypersensitivity when the antigen is a component of a cell membrane?

    <p>The target cells undergo lysis</p> Signup and view all the answers

    What is the hallmark of collagen diseases?

    <p>Fibrinoid necrosis</p> Signup and view all the answers

    In which autoimmune disease is systemic fibrosis known to affect the skin, GIT, lung, myocardium & kidneys?

    <p>Scleroderma</p> Signup and view all the answers

    What mechanism may lead to altered tissue antigenicity in autoimmune diseases?

    <p>Cross reactions between human structures and certain microbes</p> Signup and view all the answers

    Which condition results from loss of tolerance where normal tissue components are considered antigenic, leading to tissue destruction & disease development?

    <p>Contact dermatitis</p> Signup and view all the answers

    What type of hypersensitivity reaction involves cell-mediated graft rejection and caseous necrosis in tuberculosis?

    <p>Type IV hypersensitivity</p> Signup and view all the answers

    What is the mechanism of immune complex formation in Type III hypersensitivity?

    <p>Complement activation</p> Signup and view all the answers

    Which autoimmune disease is characterized by systemic fibrosis affecting skin, GIT, lung, myocardium & kidneys?

    <p>Scleroderma</p> Signup and view all the answers

    What happens in Type II hypersensitivity when the antigen is a component of a cell membrane?

    <p>Antibodies combine with the antigen producing immune complexes trapped within vascular basement membranes</p> Signup and view all the answers

    In which autoimmune disease is Hashimoto's thyroiditis an example?

    <p>Systemic lupus erythematosus (SLE)</p> Signup and view all the answers

    What type of reaction involves repeated subcutaneous injection of antigens producing local vasculitis, necrosis, and edema?

    <p>Type IV hypersensitivity</p> Signup and view all the answers

    What type of hypersensitivity reaction involves the antibodies (IgG and IgM) combining with the antigen producing immune complexes trapped within vascular basement membranes?

    <p>Type III</p> Signup and view all the answers

    Which condition results from loss of tolerance where normal tissue components are considered antigenic, leading to tissue destruction and disease development?

    <p>Hashimoto's thyroiditis</p> Signup and view all the answers

    What happens in Type II hypersensitivity when the antigen is a component of a cell membrane?

    <p>The target cells undergo lysis</p> Signup and view all the answers

    What is an example of a condition caused by Type III hypersensitivity reaction?

    <p>Acute Proliferative Post-Streptococcal Glomerulonephritis</p> Signup and view all the answers

    Which autoimmune disease is characterized by injury of collagen within and around vessels?

    <p>Scleroderma</p> Signup and view all the answers

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