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Questions and Answers
Which molecule acts as a regulatory protein to inhibit gene expression?
Which molecule acts as a regulatory protein to inhibit gene expression?
- enhancer
- repressor (correct)
- activator
- transcription factor
Which molecule promotes the repression of gene expression by combining with a repressor?
Which molecule promotes the repression of gene expression by combining with a repressor?
- metabolite
- promoter
- corepressor (correct)
- inducer
What is the function of an inducer in gene regulation?
What is the function of an inducer in gene regulation?
- binds to RNA polymerase
- alters repressor function (correct)
- activates the transcription process
- promotes degradation of mRNA
What would be the consequence of deactivating a regulatory gene in a repressible operon?
What would be the consequence of deactivating a regulatory gene in a repressible operon?
Which of the following best describes a situation where the lac operon is likely to be transcribed?
Which of the following best describes a situation where the lac operon is likely to be transcribed?
What is the role of cAMP in bacterial gene regulation?
What is the role of cAMP in bacterial gene regulation?
Which of the following repressions occurs when an operator is blocked by a repressor?
Which of the following repressions occurs when an operator is blocked by a repressor?
What effect does a corepressor have on a repressor and the associated operon?
What effect does a corepressor have on a repressor and the associated operon?
What is a potential effect of decreased chromatin condensation in eukaryotic gene expression?
What is a potential effect of decreased chromatin condensation in eukaryotic gene expression?
Which method is uniquely employed by eukaryotes for gene expression regulation?
Which method is uniquely employed by eukaryotes for gene expression regulation?
What is the primary function of RNA interference in eukaryotic cells?
What is the primary function of RNA interference in eukaryotic cells?
Which type of DNA is found in the noncoding regions of the human genome?
Which type of DNA is found in the noncoding regions of the human genome?
What role does piRNA play during gamete formation?
What role does piRNA play during gamete formation?
Which statement accurately characterizes siRNA?
Which statement accurately characterizes siRNA?
What effect does regulatory protein binding to promoter sequences have in eukaryotic gene expression?
What effect does regulatory protein binding to promoter sequences have in eukaryotic gene expression?
Which characteristic distinguishes eukaryotic gene regulation from bacterial regulation?
Which characteristic distinguishes eukaryotic gene regulation from bacterial regulation?
What is the primary method to determine the amount of mRNA generated from a gene?
What is the primary method to determine the amount of mRNA generated from a gene?
Which method would be the most effective in analyzing alternative splicing of a gene?
Which method would be the most effective in analyzing alternative splicing of a gene?
What is a common mechanism for coordinating the expression of multiple, related genes in eukaryotic cells?
What is a common mechanism for coordinating the expression of multiple, related genes in eukaryotic cells?
DNA methylation and histone acetylation are examples of which type of biochemical processes?
DNA methylation and histone acetylation are examples of which type of biochemical processes?
Which role is typically associated with general transcription factors in eukaryotic cells?
Which role is typically associated with general transcription factors in eukaryotic cells?
Which of the following does NOT contribute to the regulation of eukaryotic gene expression?
Which of the following does NOT contribute to the regulation of eukaryotic gene expression?
What is the main consequence of alternative splicing in gene expression?
What is the main consequence of alternative splicing in gene expression?
Which of the following describes a common outcome of histone acetylation on gene activity?
Which of the following describes a common outcome of histone acetylation on gene activity?
What is the role of tryptophan in the functioning of the repressor in bacteria?
What is the role of tryptophan in the functioning of the repressor in bacteria?
How does an increase in intracellular cAMP influence the transcription of the lac operon?
How does an increase in intracellular cAMP influence the transcription of the lac operon?
What is the effect of glucose on the lac operon?
What is the effect of glucose on the lac operon?
What happens to the cAMP receptor protein (CRP) as extracellular glucose levels rise?
What happens to the cAMP receptor protein (CRP) as extracellular glucose levels rise?
In what way does the binding of the cAMP receptor protein (CRP) promote the lac operon transcription?
In what way does the binding of the cAMP receptor protein (CRP) promote the lac operon transcription?
What is the consequence of a yeast mutant with histones resistant to acetylation?
What is the consequence of a yeast mutant with histones resistant to acetylation?
Which statement best describes the relationship between lactose and the lac operon?
Which statement best describes the relationship between lactose and the lac operon?
What would be the expected outcome if RNA polymerase cannot open the DNA strands at the lac operon?
What would be the expected outcome if RNA polymerase cannot open the DNA strands at the lac operon?
Which characteristic accurately describes tumor-suppressor genes?
Which characteristic accurately describes tumor-suppressor genes?
What function do the normal products of BRCA1 and BRCA2 serve?
What function do the normal products of BRCA1 and BRCA2 serve?
What effect do mutant forms of Ras protein typically have in tumors?
What effect do mutant forms of Ras protein typically have in tumors?
Which type of cancer is primarily associated with mutations in the APC gene?
Which type of cancer is primarily associated with mutations in the APC gene?
What role do tumor-suppressor genes generally perform in cell regulation?
What role do tumor-suppressor genes generally perform in cell regulation?
What is the primary outcome of deregulated Ras protein activity?
What is the primary outcome of deregulated Ras protein activity?
In what capacity do tumor-suppressor genes interact with proto-oncogenes?
In what capacity do tumor-suppressor genes interact with proto-oncogenes?
What is a significant characteristic of cancer that results from genetic changes in cell cycle control?
What is a significant characteristic of cancer that results from genetic changes in cell cycle control?
What is the role of the MyoD protein in cellular differentiation?
What is the role of the MyoD protein in cellular differentiation?
Which statement best describes cytoplasmic determinants?
Which statement best describes cytoplasmic determinants?
Why does the introduction of MyoD into neurons fail to produce muscle cells?
Why does the introduction of MyoD into neurons fail to produce muscle cells?
What type of gene expression is primarily influenced by the bicoid gene in Drosophila?
What type of gene expression is primarily influenced by the bicoid gene in Drosophila?
What distinguishes cytoplasmic determinants from other types of regulatory molecules in embryos?
What distinguishes cytoplasmic determinants from other types of regulatory molecules in embryos?
How does MyoD influence gene expression in fat cells compared to neurons?
How does MyoD influence gene expression in fat cells compared to neurons?
What characterizes the differentiated state of cells?
What characterizes the differentiated state of cells?
Which of the following options correctly explains the role of MyoD in muscle differentiation?
Which of the following options correctly explains the role of MyoD in muscle differentiation?
Flashcards
Lac Operon Repressor Binding
Lac Operon Repressor Binding
The lac operon repressor binds to the operator region of the DNA, preventing RNA polymerase from transcribing the lac genes when lactose is absent.
Glucose Breakdown and Lac Operon
Glucose Breakdown and Lac Operon
Breakdown of glucose inhibits lac operon transcription by reducing intracellular cAMP levels, causing the CRP to detach from the promoter, thus weakening transcription.
Extracellular Glucose and Lac Operon
Extracellular Glucose and Lac Operon
An increase in extracellular glucose weakens the binding of CRP to the lac promoter, reducing the rate of transcription of the lac operon.
CRP and Positive Regulation
CRP and Positive Regulation
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Acetylation Resistant Histones
Acetylation Resistant Histones
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Repressor protein
Repressor protein
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Operator
Operator
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Inducer
Inducer
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Corepressor
Corepressor
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Lac operon
Lac operon
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Regulatory gene
Regulatory gene
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Mutation in regulatory gene (repressible operon)
Mutation in regulatory gene (repressible operon)
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Conditions for lac operon transcription
Conditions for lac operon transcription
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MyoD protein effect on cell differentiation
MyoD protein effect on cell differentiation
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Differentiation instability
Differentiation instability
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Cytoplasmic determinants role
Cytoplasmic determinants role
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Drosophila bicoid gene product function
Drosophila bicoid gene product function
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Eukaryotic gene expression regulation
Eukaryotic gene expression regulation
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Tumor Suppressor Genes
Tumor Suppressor Genes
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Alternative splicing
Alternative splicing
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BRCA1 and BRCA2
BRCA1 and BRCA2
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mRNA amount
mRNA amount
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Ras Protein (tumors)
Ras Protein (tumors)
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APC gene
APC gene
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Alternative Splicing Detection
Alternative Splicing Detection
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Cancer Cell Cycle Control
Cancer Cell Cycle Control
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Coordinating gene expression
Coordinating gene expression
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Epigenetic phenomena
Epigenetic phenomena
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General transcription factors function
General transcription factors function
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Eukaryotic Gene Expression Regulation
Eukaryotic Gene Expression Regulation
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RNA Interference (RNAi)
RNA Interference (RNAi)
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Non-coding DNA
Non-coding DNA
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piRNA
piRNA
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siRNA
siRNA
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Chromatin Remodeling
Chromatin Remodeling
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Histone Acetylation
Histone Acetylation
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Study Notes
Gene Regulation
- Gene regulation is the process of controlling when and how genes are expressed.
- This process is important for all organisms.
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