10 Questions
What is the main fate of a mature naïve B cell that does not bind its cognate antigen within 2-8 weeks?
Undergo apoptosis
Which type of T cells does NOT bind native antigen directly?
Neither CD4+ nor CD8+ T cells
How do T cells differ from B cells in terms of T cell receptor (TCR) secretion?
TCR is never soluble and is always on the surface of T cells
Which type of TCR chain is more common, comprising about 90% of cases?
αβ
What happens if the δ chain 'wins' during TCR gene rearrangement?
γ genes rearrange
After successful gene rearrangement, what happens to the thymocytes in terms of CD4 and CD8 expression?
They remain CD4+ and CD8+ double positive cells
During positive selection, what determines whether a thymocyte will develop into a CD4+ or CD8+ T cell?
Recognition of MHC class I or MHC class II molecules
'Negative selection' in thymic development aims to remove thymocytes that:
'Recognize self-antigens and might cause autoimmune reactions
'Self-MHC restriction' during thymic selection refers to ensuring thymocytes recognize:
'Self' MHC molecules
What is the final outcome of successful positive selection in thymic development?
Thymocytes mature into CD4+ or CD8+ T cells.
Test your knowledge on gene rearrangement at the Pre-B cell stage, including the rearrangement of VDJ genes and light chain genes. Explore concepts such as isotype switching and organization of L chain genes.
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