Podcast
Questions and Answers
What is the main fate of a mature naïve B cell that does not bind its cognate antigen within 2-8 weeks?
What is the main fate of a mature naïve B cell that does not bind its cognate antigen within 2-8 weeks?
- Undergo apoptosis (correct)
- Remain in secondary lymphoid organs indefinitely
- Transform into plasma cells
- Differentiate into memory B cells
Which type of T cells does NOT bind native antigen directly?
Which type of T cells does NOT bind native antigen directly?
- Neither CD4+ nor CD8+ T cells (correct)
- Both CD4+ and CD8+ T cells
- CD8+ cytotoxic T cells
- CD4+ T helper cells
How do T cells differ from B cells in terms of T cell receptor (TCR) secretion?
How do T cells differ from B cells in terms of T cell receptor (TCR) secretion?
- TCR is only present during activation of T cells
- TCR is secreted in B cells, not in T cells
- TCR is soluble in both B and T cells
- TCR is never soluble and is always on the surface of T cells (correct)
Which type of TCR chain is more common, comprising about 90% of cases?
Which type of TCR chain is more common, comprising about 90% of cases?
What happens if the δ chain 'wins' during TCR gene rearrangement?
What happens if the δ chain 'wins' during TCR gene rearrangement?
After successful gene rearrangement, what happens to the thymocytes in terms of CD4 and CD8 expression?
After successful gene rearrangement, what happens to the thymocytes in terms of CD4 and CD8 expression?
During positive selection, what determines whether a thymocyte will develop into a CD4+ or CD8+ T cell?
During positive selection, what determines whether a thymocyte will develop into a CD4+ or CD8+ T cell?
'Negative selection' in thymic development aims to remove thymocytes that:
'Negative selection' in thymic development aims to remove thymocytes that:
'Self-MHC restriction' during thymic selection refers to ensuring thymocytes recognize:
'Self-MHC restriction' during thymic selection refers to ensuring thymocytes recognize:
What is the final outcome of successful positive selection in thymic development?
What is the final outcome of successful positive selection in thymic development?
