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Gene Rearrangement Pre-B Cell Stage Quiz

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Gene Rearrangement Pre-B Cell Stage Quiz

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Questions and Answers

What is the main fate of a mature naïve B cell that does not bind its cognate antigen within 2-8 weeks?

Undergo apoptosis (correct)

Remain in secondary lymphoid organs indefinitely

Transform into plasma cells

Differentiate into memory B cells

Which type of T cells does NOT bind native antigen directly?

Neither CD4+ nor CD8+ T cells (correct)

Both CD4+ and CD8+ T cells

CD8+ cytotoxic T cells

CD4+ T helper cells

How do T cells differ from B cells in terms of T cell receptor (TCR) secretion?

TCR is only present during activation of T cells

TCR is secreted in B cells, not in T cells

TCR is soluble in both B and T cells

TCR is never soluble and is always on the surface of T cells (correct)

Which type of TCR chain is more common, comprising about 90% of cases?

αβ Signup and view all the answers

What happens if the δ chain 'wins' during TCR gene rearrangement?

γ genes rearrange Signup and view all the answers

After successful gene rearrangement, what happens to the thymocytes in terms of CD4 and CD8 expression?

They remain CD4+ and CD8+ double positive cells Signup and view all the answers

During positive selection, what determines whether a thymocyte will develop into a CD4+ or CD8+ T cell?

Recognition of MHC class I or MHC class II molecules Signup and view all the answers

'Negative selection' in thymic development aims to remove thymocytes that:

'Recognize self-antigens and might cause autoimmune reactions Signup and view all the answers

'Self-MHC restriction' during thymic selection refers to ensuring thymocytes recognize:

'Self' MHC molecules Signup and view all the answers

What is the final outcome of successful positive selection in thymic development?

Thymocytes mature into CD4+ or CD8+ T cells. Signup and view all the answers