Gene Involvement in Signaling Pathways
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Questions and Answers

Which gene is NOT commonly associated with the PI3K/Akt Signaling Pathway?

  • TMEM178
  • SLC7A8
  • ELOVL5
  • HOOK2 (correct)

    • Which pathway includes the gene RUNX3?

  • NF-κB Signaling Pathway
  • EMT (Epithelial-Mesenchymal Transition) (correct)
  • Hypoxia-Induced Signaling
  • Wnt/β-Catenin Pathway (correct)

    • Which of the following pathways is involved with SLC22A3?

  • TGF-β Signaling Pathway (correct)
  • Autophagy and Cell Survival (correct)
  • Angiogenesis and Tumor Vasculature
  • DNA Repair Pathways

    • Which gene appears in both the Wnt/β-Catenin and TGF-β Signaling Pathways?

    <p>SOX2 (C)</p> Signup and view all the answers

    Which gene is exclusively listed under the Apoptosis and Survival Pathways?

    <p>PTPRN2 (A)</p> Signup and view all the answers

    Which of the following is associated with the process of Invasion and Metastasis?

    <p>GRM8 (D)</p> Signup and view all the answers

    What gene is related to Regulation of Lipogenesis and Fatty Acid Metabolism?

    <p>MLXIPL (B)</p> Signup and view all the answers

    Which pathway does not involve the gene SLC7A8?

    <p>Regulation of Estrogen Signaling (C)</p> Signup and view all the answers

    Flashcards

    PI3K/Akt Pathway

    A pathway involved in cell growth, survival, and metabolism, characterized by genes such as SOX2, SLC22A3, and more.

    Wnt/β-Catenin Pathway

    A signaling pathway that regulates gene expression and is critical in cell development, featuring genes like SOX2 and RUNX3.

    TGF-β Signaling Pathway

    Transforming growth factor-beta pathway involved in cellular growth and development, including genes like SOX2 and PTPRN2.

    MAPK/ERK Pathway

    A pathway associated with cell division and differentiation, prominently includes genes such as SOX2 and ELOVL5.

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    Apoptosis Pathways

    Pathways regulating programmed cell death, including genes like RP11-69M1.3 and PTPRN2.

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    DNA Repair Pathways

    Mechanisms ensuring the integrity of DNA, featuring key genes like RP11-69M1.3.

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    Hypoxia-Induced Signaling

    Pathways activated in low oxygen conditions, involving genes like SLC22A3 and SLC7A8.

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    Cancer Stem Cells (CSCs)

    Specialized cells that drive tumor growth, often regulated by genes like HOOK2.

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    Study Notes

    Pathways and Gene Involvement

    • PI3K/Akt Signaling Pathway: Genes involved include SOX2, SLC22A3, RP11-69M1.3, RUNX3, PTPRN2, cg08183724, cg21909390, cg1293030, and SLC7A8.

    • Wnt/β-Catenin Pathway: Genes associated are SOX2, RP11-69M1.3, RUNX3, PTPRN2, cg16611264, cg08183724, cg21909390, cg1293030, TMEM178B.

    • TGF-β Signaling Pathway: Associated genes are SOX2, SLC22A3, RP11-69M1.3, RUNX3, PTPRN2, cg16611264, cg08183724, cg21909390, cg1293030.

    • MAPK/ERK Pathway: Genes related are SOX2, SLC22A3, RP11-69M1.3, cg08183724, cg21909390, cg1293030, ELOVL5.

    • Cell Cycle Regulation: Genes linked to cell cycle regulation are RP11-69M1.3, cg16611264, cg08183724, SLC7A8

    • Apoptosis and Survival: Associated genes are RP11-69M1.3, PTPRN2, cg16611264, cg08183724, SLC7A8.

    • DNA Repair Pathways: RP11-69M1.3, and associated genes are cg16611264, cg08183724.

    • EMT (Epithelial-Mesenchymal Transition): Genes involved are RP11-69M1.3, RUNX3.

    • NF-κB Signaling Pathway: Genes involved are PTPRN2, cg21909390, cg1293030.

    • Notch Signaling Pathway: cg21909390, cg1293030 are associated genes.

    • Hypoxia-Induced Signaling: SLC22A3, SLC7A8, MLXIPL are related genes.

    • Angiogenesis and Tumor Vasculature: GRM8, SLC7A8 are involved.

    • Invasion and Metastasis: TMEM178, ELOVL5, MLXIPL have association.

    • Autophagy and Cell Survival: SLC22A3, HOOK2, TMEM178, ELOVL5 are related genes.

    • Cancer Stem Cells (CSCs) and Tumorigenesis:

    • Regulation of Estrogen Signaling: HOOK2.

    • Ion Transport and Membrane Potential: HOOK2.

    • Regulation of Lipogenesis and Fatty Acid Metabolism: TMEM178, MLXIPL are related genes.

    • Regulation of Tumor Cell Growth: GRM8.

    • Fatty Acid Metabolism and Membrane Composition: ELOVL5 is a key gene.

    • Glucose Metabolism and the Warburg Effect: MLXIPL is associated.

    Diagrammatic Representation (Page 2):

    • Diagram shows gene involvement in pathways Illustrates the number of genes associated with various pathways. The most involved pathways are indicated visually

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    Description

    This quiz explores the involvement of various genes in multiple critical signaling pathways, including the PI3K/Akt, Wnt/β-Catenin, and TGF-β pathways among others. Assess your understanding of how these genes contribute to cellular functions such as cell cycle regulation, apoptosis, and DNA repair.

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