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What is the primary function of the gastrointestinal system?
What is the primary function of the gastrointestinal system?
Which part of the digestive system is primarily responsible for carbohydrate digestion?
Which part of the digestive system is primarily responsible for carbohydrate digestion?
What is a main function of the gastric pits in the stomach?
What is a main function of the gastric pits in the stomach?
Which organ serves as a passageway for food and also connects the gastrointestinal system with the respiratory system?
Which organ serves as a passageway for food and also connects the gastrointestinal system with the respiratory system?
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What occurs in the esophagus during digestion?
What occurs in the esophagus during digestion?
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Which of the following correctly identifies the components of the gastrointestinal system?
Which of the following correctly identifies the components of the gastrointestinal system?
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What is the role of the pylorus sphincter in the digestive process?
What is the role of the pylorus sphincter in the digestive process?
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Which digestive enzyme is primarily secreted by the salivary glands?
Which digestive enzyme is primarily secreted by the salivary glands?
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What is the primary function of the villi cells in the small intestine?
What is the primary function of the villi cells in the small intestine?
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What role do the beneficial bacteria in the large intestine play?
What role do the beneficial bacteria in the large intestine play?
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What is the function of the submucosal plexus in the gastrointestinal tract?
What is the function of the submucosal plexus in the gastrointestinal tract?
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How often do epithelial cells lining the villi and microvilli renew themselves?
How often do epithelial cells lining the villi and microvilli renew themselves?
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What is primarily absorbed in the large intestine?
What is primarily absorbed in the large intestine?
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What can result from problems with the beneficial bacteria in the large intestine?
What can result from problems with the beneficial bacteria in the large intestine?
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What is the innermost layer of the gastrointestinal tract called?
What is the innermost layer of the gastrointestinal tract called?
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What dietary component can ease movements through the large intestine and reduce constipation risk?
What dietary component can ease movements through the large intestine and reduce constipation risk?
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What role do bile salts play in fat digestion?
What role do bile salts play in fat digestion?
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Which enzyme is NOT involved in protein digestion?
Which enzyme is NOT involved in protein digestion?
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Where does most absorption of nutrients occur in the digestive system?
Where does most absorption of nutrients occur in the digestive system?
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What is the purpose of defecation in the digestive process?
What is the purpose of defecation in the digestive process?
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Which of the following components is NOT involved in triglyceride digestion?
Which of the following components is NOT involved in triglyceride digestion?
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What does the process of absorption entail?
What does the process of absorption entail?
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Hormone-sensitive lipase is primarily responsible for what function?
Hormone-sensitive lipase is primarily responsible for what function?
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Which process involves the breakdown of food in the gastrointestinal tract?
Which process involves the breakdown of food in the gastrointestinal tract?
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What type of contractions are characterized by maintaining contractions over minutes or hours?
What type of contractions are characterized by maintaining contractions over minutes or hours?
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Which specialized cells generate spontaneous waves of depolarization in the gastrointestinal tract?
Which specialized cells generate spontaneous waves of depolarization in the gastrointestinal tract?
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What is the predominant frequency of slow waves in the small intestine?
What is the predominant frequency of slow waves in the small intestine?
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What are the primary components of digestive juices secreted by the gastrointestinal tract?
What are the primary components of digestive juices secreted by the gastrointestinal tract?
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What type of contraction predominantly occurs in the antrum of the stomach?
What type of contraction predominantly occurs in the antrum of the stomach?
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What regulates the amplitude and frequency of slow waves in the gastrointestinal tract?
What regulates the amplitude and frequency of slow waves in the gastrointestinal tract?
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What is the function of the pyloric sphincter during digestion?
What is the function of the pyloric sphincter during digestion?
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Which type of GI motility involves the rhythmic contraction and relaxation of muscles to propel contents forward?
Which type of GI motility involves the rhythmic contraction and relaxation of muscles to propel contents forward?
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What hormone stimulates bicarbonate secretion and inhibits acid secretion?
What hormone stimulates bicarbonate secretion and inhibits acid secretion?
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Which hormone is primarily released in response to the presence of fat and protein in the duodenum?
Which hormone is primarily released in response to the presence of fat and protein in the duodenum?
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What is the primary function of Gastrin?
What is the primary function of Gastrin?
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Which hormone helps inhibit food intake and delay gastric emptying?
Which hormone helps inhibit food intake and delay gastric emptying?
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Motilin is primarily stimulated by which neurotransmitter?
Motilin is primarily stimulated by which neurotransmitter?
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Which hormone is released in response to increased gastric acidity?
Which hormone is released in response to increased gastric acidity?
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What is a direct effect of Cholecystokinin on the gastrointestinal tract?
What is a direct effect of Cholecystokinin on the gastrointestinal tract?
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Which site of production is correct for Secretin?
Which site of production is correct for Secretin?
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What is the primary mechanism of H+ transport in the secretion of HCl?
What is the primary mechanism of H+ transport in the secretion of HCl?
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What role does carbonic anhydrase play in HCl secretion?
What role does carbonic anhydrase play in HCl secretion?
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Why is the secretion of pepsinogen an important step in digestion?
Why is the secretion of pepsinogen an important step in digestion?
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Which function is NOT associated with HCl in the stomach?
Which function is NOT associated with HCl in the stomach?
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What causes the development of a peptic ulcer?
What causes the development of a peptic ulcer?
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How is Cl- transported during HCl secretion?
How is Cl- transported during HCl secretion?
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What is the main purpose of the gastric mucosal barrier?
What is the main purpose of the gastric mucosal barrier?
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Which statement accurately describes pepsinogen?
Which statement accurately describes pepsinogen?
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Study Notes
Physiology (0603302) Ch. 6. Gastrointestinal System
- This course covers the gastrointestinal (GI) system's role in providing nutrients and electrolytes from the outside environment, maintaining homeostasis.
- The GI system is responsible for processing food.
- The GI tract is composed of the mouth, pharynx, esophagus, stomach, small intestine, large intestine, rectum, and anus.
- Accessory organs include salivary glands, liver, gallbladder, and pancreas.
Digestive System
- The digestive system is a complex system responsible for the digestion and absorption of nutrients from food.
- It includes both mechanical and chemical processes.
- Mechanical processes involve breaking down food into smaller pieces through chewing, mixing with saliva, and churning in the stomach.
- Chemical processes use enzymes to break down complex food molecules into simpler, absorbable forms.
Structure of the GI Tract
- Mouth: Contains salivary glands that produce saliva for lubrication, food degradation, and carbohydrate digestion; mechanical digestion
- Pharynx: A passageway for both food and air.
- Esophagus: Transports food from the pharynx to the stomach.
- Stomach: Contains gastric pits and cells that secrete hydrochloric acid (HCl) and pepsinogen, important for protein digestion; strong muscular wall mixes food with digestive juices.
- Small Intestine: Contains enzymes from the pancreas and small intestine for further digestion; responsible for absorption of nutrients.
- Large Intestine/Colon: Absorbs water and electrolytes; forms solid waste; beneficial gut bacteria are present.
- Rectum: Stores feces.
- Anus: Eliminates feces.
Accessory Glandular Organs
- Salivary Glands: Produce saliva, containing water, electrolytes, enzymes, and mucus.
- Liver: produces bile, important in fat emulsification; enterohepatic circulation.
- Gallbladder: Stores and concentrates bile.
- Pancreas: Produces enzymes (e.g., amylase, protease, lipase) and bicarbonate for digestion.
Mouth
- The primary site of mechanical digestion, and starting point of chemical reactions.
- Salivary glands secrete saliva that lubricates food for swallowing and initiates carbohydrate digestion by amylase.
- Chewing crushes food into small particles increasing the surface area for digestion.
- Food moves from the mouth to pharynx, then the esophagus to the stomach.
Stomach
- Gastric pits and cells secrete HCl and pepsinogen (protein digestion).
- Muscle contractions mix food with digestive juices.
- Chyme is moved through the pylorus sphincter to the small intestine.
Small Intestine
- Enzymes from the pancreas and small intestine further digest food.
- Villi and microvilli increase surface area for absorption.
- Cells lining villi/microvilli are called enterocytes.
Large Intestine
- Absorbs water and electrolytes.
- Forms feces.
- Contains beneficial bacteria that aid in digestion and vitamin production.
Four Layers of the GI Tract
- Mucosa: Innermost layer; protective, secretion, and absorption
- Submucosa: Connective tissue layer; neurons for distensibility and elasticity
- Muscularis: Two layers of smooth muscle layers; peristalsis and mixing
- Serosa: Outermost layer; connective tissue for lubrication
Motility of the GI Tract
- Phasic Contractions: Short, alternating contractions for mixing and propelling food.
- Tonic Contractions: Sustained contractions for holding substances in portions of the tract; sphincters.
- Exceptions include voluntary muscles of mouth and end of rectum.
- Interstitial cells of Cajal (ICC) - specialized cells that act as pacemakers.
Gastric Gland Cells
- Exocrine cells: Secrete digestive juices including HCI, pepsinogen, and mucus
- Parietal cells: Secrete HCl
- Chief cells: Secrete pepsinogen.
- Mucous neck cells: Secrete mucus.
Gastric Mucosal Barrier
- Protects the stomach lining from the highly acidic environment.
- Mucus and bicarbonate rich mucus offer a physical and chemical protective barrier against acid digestion.
- Tight junctions prevent HCl penetration of epithelial cells, and impermeable to H+.
Intrinsic Factor
- Secreted in parietal cells.
- Is crucial for vitamin B12 absorption.
- A deficiency can cause pernicious anemia.
Pancreatic Secretion
- Exocrine pancreas: Secreats digestive enzymes and bicarbonate into duodenum
- Acinar cells secrete digestive enzymes in inactive form (e.g., proteases, nucleases).
- Duct cells neutralize acidic chyme with alkaline bicarbonate.
- Pancreatic enzymes function best in a neutral pH
Liver Secretion
- Liver secretes bile salts, cholesterol, and bilirubin into duodenum.
- Bile salts emulsify fats, enhancing fat digestion.
- Bile salts/cholesterol/bilirubin are reabsorbed via enterohepatic circulation.
Digestion
- Mechanical digestion: Breaks down food physically (e.g., chewing, churning).
- Chemical digestion: Breaks down food chemically using enzymes (e.g., amylase, pepsin).
Absorption
- Passage of nutrients/water/electrolytes into the blood or lymphatic system.
Defecation
- Elimination of indigestible substances from the body. This occurs after water is absorbed from chyme in large intestine.
Regulation of GI Tract Functions
- Intrinsic regulation: Occurs within the gut itself.
- Extrinsic regulation: From outside the gut (e.g., hormonal or nervous).
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Test your knowledge of the gastrointestinal system and its functions with this quiz. From digestion processes to the roles of various organs and enzymes, assess your understanding of how the body processes food.