Gastrointestinal and Antiemetic Drugs Quiz

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Questions and Answers

What is the primary cause of peptic ulcer disease?

  • Gram positive bacteria
  • Gram negative bacteria (correct)
  • NSAIDs
  • Increased HCl secretion

Which of the following antibiotics is used in triple therapy to treat peptic ulcer disease?

  • Tetracycline
  • Metronidazole
  • Amoxicillin
  • All of the above (correct)

What is the main mechanism of action of H2 receptor antagonists?

  • Inhibition of prostaglandin E2
  • Inhibition of H+/K+ ATPase enzyme
  • Stimulation of H+/K+ ATPase enzyme
  • Receptor mediated binding of acetylcholine, histamine and gastrin (correct)

What is a common side effect of cimetidine?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary mechanism of action of proton pump inhibitors (PPIs)?

<p>Inhibition of H+/K+ ATPase enzyme (D)</p> Signup and view all the answers

Which of the following tests is used to diagnose H. pylori infection?

<p>All of the above (D)</p> Signup and view all the answers

What is the result of the reaction between antacids and HCl?

<p>Formation of CO2 and CaCl2 (A)</p> Signup and view all the answers

What is the therapeutic use of antacids?

<p>To relieve symptoms of peptic ulcer disease, heartburn, and GERD (B)</p> Signup and view all the answers

Where are the chemoreceptor triggers located?

<p>Outside the blood-brain barrier in the area postrema (D)</p> Signup and view all the answers

What is a common side effect of taking aluminum hydroxide?

<p>Constipation (A)</p> Signup and view all the answers

What is the mechanism of action of sucralfate?

<p>It binds to positively charged groups in mucosal protein (B)</p> Signup and view all the answers

What is the mechanism of action of chemotherapeutic agents on the vomiting center?

<p>They directly activate the vomiting center (B)</p> Signup and view all the answers

What is the advantage of 5-HT3 receptor blockers as antiemetic drugs?

<p>They have a long duration of action (D)</p> Signup and view all the answers

What is the use of bismuth subsalicylate?

<p>To heal H.pylori-related peptic ulcers (D)</p> Signup and view all the answers

What is the mechanism of action of metoclopramide as an antiemetic drug?

<p>It works as an antagonist of dopamine receptor type-2 (C)</p> Signup and view all the answers

What is a consequence of uncontrolled vomiting in chemotherapy-induced emesis?

<p>Dehydration and metabolic imbalances (C)</p> Signup and view all the answers

What is the side effect of phenothiazines, such as prochlorperazine, as antiemetic drugs?

<p>Hypotension, restlessness, and sedation (C)</p> Signup and view all the answers

What is the mechanism of action of butyrophenones, such as droperidol and haloperidol, as antiemetic drugs?

<p>They block dopamine receptors (A)</p> Signup and view all the answers

What is the primary mechanism of antiemetic activity for corticosteroids?

<p>The exact mechanism is not known (A)</p> Signup and view all the answers

Which of the following antiemetic agents is known to prolong QT intervals?

<p>An unspecified antiemetic agent (C)</p> Signup and view all the answers

What is the primary action of antimotility agents on the gut?

<p>Activating presynaptic opioid receptors (B)</p> Signup and view all the answers

What is a common side effect of antimotility agents?

<p>Abdominal cramps (B)</p> Signup and view all the answers

What is the mechanism of action of bismuth sub salicylate?

<p>Decrease fluid secretion in the bowel (A)</p> Signup and view all the answers

What is the primary mechanism of action of absorbents such as bismuth subsalicylate?

<p>Adsorbing intestinal toxins or microorganisms (B)</p> Signup and view all the answers

What is a common side effect of chronic laxative use?

<p>Both A and B (B)</p> Signup and view all the answers

What is a potential complication of using antimotility agents in young children or patients with severe colitis?

<p>Toxic megacolon (A)</p> Signup and view all the answers

Which type of laxative works by activating chloride channels in the intestine?

<p>Chloride channel activators (C)</p> Signup and view all the answers

What is the primary mechanism of action of bulk laxatives?

<p>Increase stool bulk (A)</p> Signup and view all the answers

Which laxative should not be taken with mineral oil?

<p>Docusate sodium (D)</p> Signup and view all the answers

What is the primary indication for the use of lubipostone?

<p>Chronic constipation (D)</p> Signup and view all the answers

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