Gastrointestinal and Antiemetic Drugs Quiz
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Questions and Answers

What is the primary cause of peptic ulcer disease?

  • Gram positive bacteria
  • Gram negative bacteria (correct)
  • NSAIDs
  • Increased HCl secretion

    • Which of the following antibiotics is used in triple therapy to treat peptic ulcer disease?

  • Tetracycline
  • Metronidazole
  • Amoxicillin
  • All of the above (correct)

    • What is the main mechanism of action of H2 receptor antagonists?

  • Inhibition of prostaglandin E2
  • Inhibition of H+/K+ ATPase enzyme
  • Stimulation of H+/K+ ATPase enzyme
  • Receptor mediated binding of acetylcholine, histamine and gastrin (correct)

    • What is a common side effect of cimetidine?

    <p>All of the above</p> Signup and view all the answers

    What is the primary mechanism of action of proton pump inhibitors (PPIs)?

    <p>Inhibition of H+/K+ ATPase enzyme</p> Signup and view all the answers

    Which of the following tests is used to diagnose H. pylori infection?

    <p>All of the above</p> Signup and view all the answers

    What is the result of the reaction between antacids and HCl?

    <p>Formation of CO2 and CaCl2</p> Signup and view all the answers

    What is the therapeutic use of antacids?

    <p>To relieve symptoms of peptic ulcer disease, heartburn, and GERD</p> Signup and view all the answers

    Where are the chemoreceptor triggers located?

    <p>Outside the blood-brain barrier in the area postrema</p> Signup and view all the answers

    What is a common side effect of taking aluminum hydroxide?

    <p>Constipation</p> Signup and view all the answers

    What is the mechanism of action of sucralfate?

    <p>It binds to positively charged groups in mucosal protein</p> Signup and view all the answers

    What is the mechanism of action of chemotherapeutic agents on the vomiting center?

    <p>They directly activate the vomiting center</p> Signup and view all the answers

    What is the advantage of 5-HT3 receptor blockers as antiemetic drugs?

    <p>They have a long duration of action</p> Signup and view all the answers

    What is the use of bismuth subsalicylate?

    <p>To heal H.pylori-related peptic ulcers</p> Signup and view all the answers

    What is the mechanism of action of metoclopramide as an antiemetic drug?

    <p>It works as an antagonist of dopamine receptor type-2</p> Signup and view all the answers

    What is a consequence of uncontrolled vomiting in chemotherapy-induced emesis?

    <p>Dehydration and metabolic imbalances</p> Signup and view all the answers

    What is the side effect of phenothiazines, such as prochlorperazine, as antiemetic drugs?

    <p>Hypotension, restlessness, and sedation</p> Signup and view all the answers

    What is the mechanism of action of butyrophenones, such as droperidol and haloperidol, as antiemetic drugs?

    <p>They block dopamine receptors</p> Signup and view all the answers

    What is the primary mechanism of antiemetic activity for corticosteroids?

    <p>The exact mechanism is not known</p> Signup and view all the answers

    Which of the following antiemetic agents is known to prolong QT intervals?

    <p>An unspecified antiemetic agent</p> Signup and view all the answers

    What is the primary action of antimotility agents on the gut?

    <p>Activating presynaptic opioid receptors</p> Signup and view all the answers

    What is a common side effect of antimotility agents?

    <p>Abdominal cramps</p> Signup and view all the answers

    What is the mechanism of action of bismuth sub salicylate?

    <p>Decrease fluid secretion in the bowel</p> Signup and view all the answers

    What is the primary mechanism of action of absorbents such as bismuth subsalicylate?

    <p>Adsorbing intestinal toxins or microorganisms</p> Signup and view all the answers

    What is a common side effect of chronic laxative use?

    <p>Both A and B</p> Signup and view all the answers

    What is a potential complication of using antimotility agents in young children or patients with severe colitis?

    <p>Toxic megacolon</p> Signup and view all the answers

    Which type of laxative works by activating chloride channels in the intestine?

    <p>Chloride channel activators</p> Signup and view all the answers

    What is the primary mechanism of action of bulk laxatives?

    <p>Increase stool bulk</p> Signup and view all the answers

    Which laxative should not be taken with mineral oil?

    <p>Docusate sodium</p> Signup and view all the answers

    What is the primary indication for the use of lubipostone?

    <p>Chronic constipation</p> Signup and view all the answers

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