Gastric Secretion Mechanisms Quiz

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Questions and Answers

What enzyme is responsible for the formation of carbonic acid (H2CO3) in the parietal cells?

  • Lipase
  • Carbonic anhydrase (correct)
  • Amylase
  • Pepsin

What is the primary source of hydrogen ions (H+) for hydrochloric acid (HCl) secretion in the stomach?

  • Dissociation of water molecules
  • Breakdown of ATP
  • Dissociation of carbonic acid (H2CO3) (correct)
  • Direct uptake from the bloodstream

Which of the following is NOT a factor that can stimulate the secretion of hydrochloric acid (HCl) in the stomach?

  • Acetylcholine
  • Gastrin
  • Histamine
  • Insulin (correct)

What is the primary mechanism by which omeprazole inhibits hydrochloric acid (HCl) secretion?

<p>Blocking hydrogen ion-potassium ion ATPase (D)</p> Signup and view all the answers

What is the role of the vagus nerve in the regulation of gastric secretion?

<p>Stimulates the release of gastrin and histamine (D)</p> Signup and view all the answers

Which of the following is a physiological response to a meal, leading to an increase in blood pH?

<p>Postprandial alkaline tide (C)</p> Signup and view all the answers

What is the main function of the H+-K+ ATPase in the parietal cell?

<p>Actively transporting H+ into the stomach lumen (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of hydrochloric acid (HCl) secretion in the stomach?

<p>Passive diffusion into the stomach lumen (C)</p> Signup and view all the answers

What is the main function of pepsin in protein digestion?

<p>Initiates protein digestion, breaking them down into peptides. (B)</p> Signup and view all the answers

What is the primary site for protein digestion?

<p>Small intestine (C)</p> Signup and view all the answers

Which of the following enzymes plays a role in the final breakdown of dipeptides and small polypeptides?

<p>Aminopolypeptidase (A)</p> Signup and view all the answers

Which of the following accurately describes the role of the valvulae conniventes in digestion?

<p>They increase the surface area for absorption. (B)</p> Signup and view all the answers

What is the approximate surface area of the small intestine?

<p>250 m2 (C)</p> Signup and view all the answers

Which of the following is NOT a factor that increases the absorptive area of the small intestine?

<p>Goblet cells (D)</p> Signup and view all the answers

What is the main type of absorption that occurs in the small intestine?

<p>Both active transport and passive diffusion (A)</p> Signup and view all the answers

What is the primary method for the absorption of carbohydrates?

<p>Breakdown by enzymes before absorption. (A)</p> Signup and view all the answers

Which unit focuses on the secretions of the gastrointestinal tract?

<p>Organization and Secretions of the Gastrointestinal Tract (C)</p> Signup and view all the answers

What is the total number of modules in the course?

<p>5 (B)</p> Signup and view all the answers

Which module covers the endocrine and reproductive systems?

<p>Module 3 (D)</p> Signup and view all the answers

Which unit is dedicated to the sense of taste?

<p>The Tongue and the Sense of Taste (B)</p> Signup and view all the answers

What is required for attendance in interactive sessions?

<p>95% (B)</p> Signup and view all the answers

Which of the following statements about laboratory practical sessions is correct?

<p>Participation must reach a minimum of 90%. (A)</p> Signup and view all the answers

Which unit in the course discusses the structure of the kidney?

<p>The Structure of the Kidney (A)</p> Signup and view all the answers

Which reference textbook focuses specifically on human physiology?

<p>Fox SI - Human Physiology (A)</p> Signup and view all the answers

What is the primary action of porcine CCK on pancreatic secretion?

<p>It stimulates secretion of pancreatic juice rich in enzymes. (D)</p> Signup and view all the answers

Which of the following hormones was the first ever discovered?

<p>Secretin (D)</p> Signup and view all the answers

How does secretin influence pancreatic secretion?

<p>It promotes the secretion of watery alkaline pancreatic juice. (D)</p> Signup and view all the answers

What stimulates the release of secretin in the digestive system?

<p>Acid chyme entering the duodenum. (C)</p> Signup and view all the answers

What effect does gastric inhibitory peptide have in smaller doses?

<p>It does not show inhibition of gastric secretion. (A)</p> Signup and view all the answers

What is the primary role of CCK in relation to the gall bladder?

<p>It stimulates contraction of the gall bladder. (C)</p> Signup and view all the answers

In what form is secretin initially produced before activation?

<p>Prosecretin (B)</p> Signup and view all the answers

What is one of the actions of CCK related to gastric emptying?

<p>It inhibits gastric emptying. (A)</p> Signup and view all the answers

What is the primary mechanism by which chloride ions are absorbed in the small intestine?

<p>Passive diffusion (D)</p> Signup and view all the answers

Which vitamin is absorbed specifically in the ileum of the small intestine?

<p>Vitamin B12 (D)</p> Signup and view all the answers

What role do Na+ ions play in the absorption of chloride ions?

<p>They balance the electrical gradient. (B)</p> Signup and view all the answers

Which hormone is primarily involved in stimulating the secretion of digestive juices in the intestines?

<p>Secretin (A)</p> Signup and view all the answers

What type of vitamins is dependent on fat absorption for their absorption?

<p>Fat-soluble vitamins (B)</p> Signup and view all the answers

Which hormone is associated with stimulating gallbladder contraction?

<p>Cholecystokinin (CCK) (A)</p> Signup and view all the answers

What mechanism allows for the absorption of potassium ions across the gastrointestinal mucosa?

<p>Diffusion (D)</p> Signup and view all the answers

Which hormone is responsible for inhibiting gastric motility and gastric acid secretion?

<p>Gastric inhibitory peptide (C)</p> Signup and view all the answers

What percentage of the final grade is allocated to the Computer marked Assignment?

<p>10% (B)</p> Signup and view all the answers

Which of the following is NOT a component of the final grade?

<p>Course Outline (D)</p> Signup and view all the answers

Which of these activities contribute the most to the final grade?

<p>End of Course Examination (A)</p> Signup and view all the answers

What is the minimum percentage required to pass the course?

<p>50% (A)</p> Signup and view all the answers

What advice does the course guide provide for students regarding submitting assignments?

<p>Submit assignments on time, as indicated by the due date (C)</p> Signup and view all the answers

Which of the following is NOT listed as a resource for students to utilize in this course?

<p>Social Media Platforms (C)</p> Signup and view all the answers

Flashcards

Physiology

The study of how the body functions and its various systems interact with each other.

Gastrointestinal Tract

Includes the organs involved in the breakdown of food and absorption of nutrients.

Nervous System

The control center of the body, responsible for receiving, processing, and transmitting information.

Endocrine System

A network of glands that produce and release hormones to regulate various bodily functions.

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Reproductive System

The system responsible for reproduction and the development of sexual characteristics.

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Urinary System

The system that filters waste products from the blood and produces urine.

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Special Senses

The organs responsible for our senses of taste, smell, hearing, and vision.

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Laboratory Logbook

A logbook that documents the student's participation in practical laboratory activities.

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Study Plan

A structured plan that outlines your learning goals, activities, and time management strategies to help you succeed in the course.

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Online Discussion Forum

The process of active participation in online discussions with other students, facilitated by the course coordinator.

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Laboratory Practical

A hands-on experience where you apply theoretical knowledge to real-world scenarios in a lab setting.

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End of Course Examination

An assessment that evaluates your comprehension of the course material and your ability to apply it.

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Learner-Facilitator Evaluation

A systematic evaluation of the course's effectiveness, conducted by both students and teaching staff.

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Tutor Marked Individual Assignment

A method of assessing learning through individual submissions graded by the tutor.

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Computer Marked Assignment

An assignment that is automatically graded by a computer system.

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What is hydrochloric acid (HCl) in digestion?

Hydrochloric acid (HCl) is the main component of gastric juice, secreted by parietal cells in the stomach. It plays a crucial role in digestion by breaking down food and activating digestive enzymes.

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How is HCl secreted in the stomach?

The process of secreting HCl in the stomach is active, meaning it requires energy. This is because HCl is transported against its concentration gradient, from a lower concentration inside the parietal cell to a higher concentration in the gastric lumen.

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What's the role of carbonic anhydrase in HCl production?

Carbonic anhydrase is an enzyme that helps generate hydrogen ions (H+) for HCl production. It does this by converting carbon dioxide (CO2) and water (H2O) into carbonic acid (H2CO3), which then dissociates into H+ and bicarbonate (HCO3-).

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How are hydrogen ions (H+) transported out of the parietal cell?

The H+ ions produced by carbonic anhydrase are then exchanged with potassium ions (K+) via the H+-K+ ATPase pump, a protein embedded in the parietal cell membrane. This pump uses energy from ATP to actively transport H+ into the gastric lumen.

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How is chloride (Cl-) involved in HCl production?

Chloride ions (Cl-) are also actively transported from the cell into the gastric lumen. This Cl- combines with the H+ ions to form HCl, the final product of gastric acid secretion.

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What happens to water during HCl secretion?

The secretion of HCl into the stomach lumen is followed by the passive transport of water. This water movement helps maintain the proper volume and concentration of gastric juice.

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What happens to bicarbonate (HCO3-) during HCl secretion?

The HCO3- ions generated during the formation of HCl are transported into the blood, combining with sodium ions (Na+) to form sodium bicarbonate (NaHCO3). This process contributes to the "alkaline tide" observed after a meal.

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What agents stimulate HCl secretion?

Agents like gastrin, acetylcholine, and histamine stimulate the parietal cells to produce and release hydrochloric acid (HCl). This is achieved through different signaling pathways within the stomach.

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What is Porcine CCK?

Porcine CCK (cholecystokinin) exists in various forms with varying chain lengths (e.g., 58, 39, 33, 12, 8, and 4 amino acids). It has a short half-life of 5 minutes and plays a vital role in digestion and other bodily processes.

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How does CCK affect pancreatic juice?

CCK stimulates the release of pancreatic juice rich in enzymes, enhancing digestion. It also works with secretin to produce an alkaline pancreatic juice, neutralizing stomach acid.

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What is the role of CCK in gastric emptying?

CCK slows down the emptying of the stomach, allowing for proper digestion and nutrient absorption.

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How does CCK affect pancreas growth?

CCK promotes the growth of pancreatic exocrine cells, ensuring the pancreas can produce enough digestive enzymes.

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What is Secretin?

Secretin is a peptide hormone with 27 amino acids. It was the first discovered hormone, playing a crucial role in regulating digestion.

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Digestion

The process of breaking down food into smaller molecules that the body can absorb.

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Where is Secretin produced and stimulated?

Secretin is released by S cells in the duodenum, jejunum, and ileum, primarily in response to acidic chyme entering the small intestine.

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Protein digestion

A process that starts in the stomach and continues in the small intestine, breaking down proteins into smaller units.

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How does Secretin affect bicarbonate secretion?

Secretin increases bicarbonate (HCO3-) secretion in the pancreatic duct and biliary tract, making pancreatic juice more alkaline.

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Pepsin

An enzyme found in the stomach that breaks down proteins, particularly collagen and albuminoid.

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Trypsin, chymotrypsin, carboxypolypeptidase

Specialized enzymes that break down proteins into smaller peptides and amino acids in the small intestine.

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How does Secretin work with CCK?

Secretin enhances the action of CCK in producing pancreatic juice rich in digestive enzymes, further aiding in the digestion process.

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Absorption

The process by which digested nutrients, water, and other substances are absorbed from the digestive tract into the bloodstream.

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Villi

Tiny finger-like projections in the small intestine that significantly increase the surface area for nutrient absorption.

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Active transport

The process of transporting nutrients from the digestive tract into the bloodstream, often requiring energy.

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Diffusion

The movement of nutrients across a membrane from an area of high concentration to low concentration, without requiring energy.

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Chloride Ion Absorption

Chloride ions move passively along with sodium ions to maintain electrical balance during absorption in the small intestine.

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Potassium Ion Absorption

Potassium ions are absorbed across the gastrointestinal mucosa by simple diffusion.

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Water-Soluble Vitamin Absorption

Water-soluble vitamins are easily absorbed by the body due to their solubility in water.

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Fat-Soluble Vitamin Absorption

Fat-soluble vitamin absorption depends on fat absorption in the body.

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Vitamin Absorption Location

Most vitamins are absorbed in the upper small intestine, but vitamin B12 is absorbed in the ileum.

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Gastrin

Gastrin is a hormone produced by the stomach that stimulates gastric acid secretion and increases stomach motility.

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Cholecystokinin (CCK)

Cholecystokinin (CCK) is produced by the small intestine and stimulates the release of bile from the gallbladder and pancreatic enzymes.

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Secretin

Secretin is a hormone produced by the small intestine that stimulates the release of bicarbonate from the pancreas, which neutralizes stomach acid.

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Study Notes

Course Information

  • Course: Human Physiology II
  • Course Code: NSC 222
  • Course Team: Dr. R.O. Akomolafe, Dr. A. O. Ayoka, Dr. O. S. Akinsomisoye (Course Developers/Writers), Mr. O. S. Olukiran (Co-writer), Dr. O.O. Irinoye & Dr T.O. Oladogba (Course Editors), Dr. Umar Zayyanu Usman, MBBS, MSc, PhD. (Reviewer) - Usmanu Danfodiyo University, Sokoto
  • Institution: National Open University of Nigeria (NOUN)
  • Year: 2022

Course Materials

  • Course Guide
  • Study Units
  • Textbooks (hard and electronic)
  • Book of Laboratory Practical
  • Assignment File/Portfolio

Study Units

  • Module 1: Gastrointestinal Physiology
    • Unit 1: Organization and Secretions of the Gastrointestinal Tract
    • Unit 2: Gastrointestinal Motility
    • Unit 3: Gastrointestinal Hormones, Digestion and Absorption
  • Module 2: Nervous System
    • Unit 1: Overview of the Nervous System
    • Unit 2: Integration of Central Nervous System with other Systems
  • Module 3: Endocrine System and Reproductive System
    • Unit 1: The Endocrine System
    • Unit 2: The Reproductive System
  • Module 4: Urinary System
    • Unit 1: Introduction to Urinary System
    • Unit 2: The Structure of the Kidney
  • Module 5: The Special Senses
    • Unit 1: The Tongue and the Sense of Taste
    • Unit 2: The Nose and the Sense of Smell
    • Unit 3: The Ear and the Sense of Hearing
    • Unit 4: The Eyes and the Sense of Vision

Course Requirements and Expectations

  • Attendance of 95% of all interactive sessions
  • Submission of all assignments
  • Participation in all CMA and laboratory sessions
  • Submission of reports from all laboratory practical sessions
  • Attendance of the final course examination
  • Versatility in basic computer skills.
  • Participation in all laboratory practicals up to 90% of the time.
  • Submitting personal reports from laboratory practical sessions on schedule.
  • Logging in to the class online discussion board at least once a week and contributing to ongoing discussions.
  • Contributing actively to group seminar presentations.
  • Using a computer (laptop, desktop or tablet)
  • Internet access (preferably broadband)
  • MS Office software (Word Processor, Powerpoint, Spreadsheet)
  • nBrowser – Preferably Internet Explorer, Moxilla Firefox
  • Adobe Acrobat Reader

Course Evaluation

  • In-Course Examination
  • Final Examination
  • Learner-Facilitator evaluation of the course

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