Gastric Malignancy: Symptoms and Risk Factors
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Questions and Answers

Which gene mutation is linked to hereditary diffuse gastric cancer?

  • E-cadherin (CDH1) (correct)
  • PDGFR-alpha
  • c-KIT (CD117)
  • CDKN2A

What type of cells are found in Krukenburg (Ovarian) tumor?

  • Epithelioid cells
  • Spindle cells
  • Neuroendocrine cells
  • Mucin-filled signet ring cells (correct)

What is the cell of origin for GastroIntestinal Stromal Tumors (GIST)?

  • Interstitial cell of Cajal (correct)
  • Adipocyte
  • Smooth muscle cell
  • Neuroendocrine cell

Which gene mutation is responsible for approximately 70-80% of GastroIntestinal Stromal Tumors (GIST)?

<p>c-KIT (CD117) (B)</p> Signup and view all the answers

What are the overexpressed/high levels of bio-markers associated with Neuroendocrine Tumors (NETs) or Carcinoid?

<p>Chromogranin A and Synaptophysin (D)</p> Signup and view all the answers

Which location is the least progressive for Foregut Carcinoid?

<p>Stomach (B)</p> Signup and view all the answers

What is the most common primary gastrointestinal lymphoma?

<p>Mucosa-associated lymphoid tissue (MALT) lymphoma (C)</p> Signup and view all the answers

What is the mnemonic used to remember the locations where neuroendocrine cells are found?

<p>TOOTH mnemonic (C)</p> Signup and view all the answers

What type of tumor is GastroIntestinal Stromal Tumor (GIST)?

<p>Soft tissue sarcoma (C)</p> Signup and view all the answers

What is the characteristic histology feature of Lymphoma derived from H. pylori infection?

<p>Bland nuclei with salt and pepper chromatin (D)</p> Signup and view all the answers

What is the standard treatment for ulcer disease, stomach cancer, injury, and other diseases of the stomach?

<p>Gastrectomy (C)</p> Signup and view all the answers

Which type of Billroth involves anastomosis of the gastric stump to the duodenum?

<p>Billroth I (A)</p> Signup and view all the answers

What is the term for bile flowing backward into the stomach or esophagus?

<p>Bile reflux (A)</p> Signup and view all the answers

Which complication involves parts of the small intestine bulging through the membrane that attaches the intestine to the abdominal wall?

<p>Internal hernia (D)</p> Signup and view all the answers

What is the term for the stomach not processing food as quickly as it should, which can occur after gastrectomy?

<p>Post-surgery gastroparesis (A)</p> Signup and view all the answers

After gastrectomy, how long does it generally take to regain energy levels and get used to new eating habits?

<p>~3 months to 6 months or longer (C)</p> Signup and view all the answers

What is the term for the condition where food travels to the small intestine before it's broken down properly?

<p>Dumping syndrome (B)</p> Signup and view all the answers

Which type of Billroth involves anastomosis of the gastric stump to the jejunum?

<p>Billroth II (D)</p> Signup and view all the answers

What term describes a leak at the attachment site?

<p>Anastomotic Leak (B)</p> Signup and view all the answers

What term is used when there is narrowing at the attachment site that connects partial stomach or esophagus and small intestine?

<p>Narrowing at the attachment site (D)</p> Signup and view all the answers

What is the most common malignant type of stomach cancer?

<p>Adenocarcinoma (B)</p> Signup and view all the answers

Which early stage symptom is commonly associated with gastric cancer?

<p>Dysphagia (D)</p> Signup and view all the answers

In what way does H pylori cause gastric cancer?

<p>By causing chronic inflammation and impairing DNA (C)</p> Signup and view all the answers

Which of the following is NOT a risk factor for gastric cancer?

<p>High dietary fiber intake (B)</p> Signup and view all the answers

What is the role of CagA cytotoxin released by H pylori?

<p>It causes chronic inflammation and impairs DNA (C)</p> Signup and view all the answers

Which cell lining of the stomach does adenocarcinoma commonly start in?

<p>Antrum cell lining (C)</p> Signup and view all the answers

What is the main method of treatment for gastric cancer involving the removal of the tumor?

<p>Surgery (resection) (B)</p> Signup and view all the answers

What does H pylori release to raise the pH on the surface of epithelial cells?

<p>Urease (A)</p> Signup and view all the answers

What is a common symptom in later stages of gastric cancer that is more likely to occur in men?

<p>'GI bleed' (A)</p> Signup and view all the answers

Which condition is not associated with an increased risk of developing gastric cancer?

<p>High dietary fiber intake (B)</p> Signup and view all the answers

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