Gastric Malignancy: Symptoms and Risk Factors
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Questions and Answers

Which gene mutation is linked to hereditary diffuse gastric cancer?

  • E-cadherin (CDH1) (correct)
  • PDGFR-alpha
  • c-KIT (CD117)
  • CDKN2A
  • What type of cells are found in Krukenburg (Ovarian) tumor?

  • Epithelioid cells
  • Spindle cells
  • Neuroendocrine cells
  • Mucin-filled signet ring cells (correct)
  • What is the cell of origin for GastroIntestinal Stromal Tumors (GIST)?

  • Interstitial cell of Cajal (correct)
  • Adipocyte
  • Smooth muscle cell
  • Neuroendocrine cell
  • Which gene mutation is responsible for approximately 70-80% of GastroIntestinal Stromal Tumors (GIST)?

    <p>c-KIT (CD117)</p> Signup and view all the answers

    What are the overexpressed/high levels of bio-markers associated with Neuroendocrine Tumors (NETs) or Carcinoid?

    <p>Chromogranin A and Synaptophysin</p> Signup and view all the answers

    Which location is the least progressive for Foregut Carcinoid?

    <p>Stomach</p> Signup and view all the answers

    What is the most common primary gastrointestinal lymphoma?

    <p>Mucosa-associated lymphoid tissue (MALT) lymphoma</p> Signup and view all the answers

    What is the mnemonic used to remember the locations where neuroendocrine cells are found?

    <p>TOOTH mnemonic</p> Signup and view all the answers

    What type of tumor is GastroIntestinal Stromal Tumor (GIST)?

    <p>Soft tissue sarcoma</p> Signup and view all the answers

    What is the characteristic histology feature of Lymphoma derived from H. pylori infection?

    <p>Bland nuclei with salt and pepper chromatin</p> Signup and view all the answers

    What is the standard treatment for ulcer disease, stomach cancer, injury, and other diseases of the stomach?

    <p>Gastrectomy</p> Signup and view all the answers

    Which type of Billroth involves anastomosis of the gastric stump to the duodenum?

    <p>Billroth I</p> Signup and view all the answers

    What is the term for bile flowing backward into the stomach or esophagus?

    <p>Bile reflux</p> Signup and view all the answers

    Which complication involves parts of the small intestine bulging through the membrane that attaches the intestine to the abdominal wall?

    <p>Internal hernia</p> Signup and view all the answers

    What is the term for the stomach not processing food as quickly as it should, which can occur after gastrectomy?

    <p>Post-surgery gastroparesis</p> Signup and view all the answers

    After gastrectomy, how long does it generally take to regain energy levels and get used to new eating habits?

    <p>~3 months to 6 months or longer</p> Signup and view all the answers

    What is the term for the condition where food travels to the small intestine before it's broken down properly?

    <p>Dumping syndrome</p> Signup and view all the answers

    Which type of Billroth involves anastomosis of the gastric stump to the jejunum?

    <p>Billroth II</p> Signup and view all the answers

    What term describes a leak at the attachment site?

    <p>Anastomotic Leak</p> Signup and view all the answers

    What term is used when there is narrowing at the attachment site that connects partial stomach or esophagus and small intestine?

    <p>Narrowing at the attachment site</p> Signup and view all the answers

    What is the most common malignant type of stomach cancer?

    <p>Adenocarcinoma</p> Signup and view all the answers

    Which early stage symptom is commonly associated with gastric cancer?

    <p>Dysphagia</p> Signup and view all the answers

    In what way does H pylori cause gastric cancer?

    <p>By causing chronic inflammation and impairing DNA</p> Signup and view all the answers

    Which of the following is NOT a risk factor for gastric cancer?

    <p>High dietary fiber intake</p> Signup and view all the answers

    What is the role of CagA cytotoxin released by H pylori?

    <p>It causes chronic inflammation and impairs DNA</p> Signup and view all the answers

    Which cell lining of the stomach does adenocarcinoma commonly start in?

    <p>Antrum cell lining</p> Signup and view all the answers

    What is the main method of treatment for gastric cancer involving the removal of the tumor?

    <p>Surgery (resection)</p> Signup and view all the answers

    What does H pylori release to raise the pH on the surface of epithelial cells?

    <p>Urease</p> Signup and view all the answers

    What is a common symptom in later stages of gastric cancer that is more likely to occur in men?

    <p>'GI bleed'</p> Signup and view all the answers

    Which condition is not associated with an increased risk of developing gastric cancer?

    <p>High dietary fiber intake</p> Signup and view all the answers

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