Echographie du foie
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Questions and Answers

What does the blue color in the color Doppler image indicate regarding portal blood flow in the dog?

  • No blood flow detected
  • Blood flow towards the transducer
  • Blood flow away from the transducer (correct)
  • Blood flow in the reverse direction
  • Why is ultrasound considered unreliable for establishing a diagnosis of liver disease?

  • It cannot detect microscopic evidence of disease. (correct)
  • It does not provide details about liver function.
  • It is only effective in identifying large tumors.
  • It cannot differentiate between healthy and diseased tissue.
  • Which of the following factors might influence the hepatic arterial resistance index (RI) in dogs?

  • Nutritional intake
  • Weight of the dog
  • Presence of congenital fistulas (correct)
  • Age of the dog
  • How many portal triads are recommended to ensure adequate diagnostic utility in liver biopsies?

    <p>12 to 15 portal triads (A)</p> Signup and view all the answers

    What is an important consideration when conducting liver biopsies in patients?

    <p>The presence of coagulation abnormalities. (D)</p> Signup and view all the answers

    What common clinical condition may cause portal vein thrombosis in dogs?

    <p>Acquired hepatic insufficiency (A)</p> Signup and view all the answers

    What can potentially happen 24 hours after a liver biopsy in some cats?

    <p>They may not reach the lowest packed cell volume (PCV). (D)</p> Signup and view all the answers

    What is one of the recommended materials to use for preparing the skin before an ultrasound examination?

    <p>Alcohol (A)</p> Signup and view all the answers

    What is the typical RI value for the hepatic artery in normal, fasted dogs as reported?

    <p>1.5 ± 0.4 (A)</p> Signup and view all the answers

    Which imaging technique provides a measurement of flow velocity in the portal vein?

    <p>Color Doppler ultrasound (B)</p> Signup and view all the answers

    Why might some clinicians advocate for culturing liver samples?

    <p>To check for the presence of bacteria. (D)</p> Signup and view all the answers

    What is advised to improve the transmission of ultrasound waves during examination?

    <p>Using acoustic coupling gel. (C)</p> Signup and view all the answers

    What characteristic pattern does nodular hyperplasia exhibit when imaged?

    <p>Hypoechoic with an isoechoic center (D)</p> Signup and view all the answers

    What is one risk associated with inadequate sample sizes in liver biopsies?

    <p>Erroneous measurement of copper concentration. (B)</p> Signup and view all the answers

    What should be considered abnormal when detected after the first few weeks of life?

    <p>Patent ductus venosus (D)</p> Signup and view all the answers

    Which imaging method is NOT mentioned for confirming a patent ductus venosus?

    <p>Magnetic resonance imaging (MRI) (B)</p> Signup and view all the answers

    What is the normal state of portal blood flow velocity (PBFV) in the main portal vein described as?

    <p>Relatively slow and nearly uniform (A)</p> Signup and view all the answers

    What is the cause of the small undulations in the Doppler spectral pattern of the portal vein's blood flow?

    <p>Respiratory motion of the diaphragm (B)</p> Signup and view all the answers

    What is the reported mean portal blood flow velocity (PBFV) in normal unsedated dogs?

    <p>18 ± 7.6 cm/sec (B)</p> Signup and view all the answers

    Where do the intestinal capillaries in the portal vein connect to?

    <p>Hepatic sinusoids (D)</p> Signup and view all the answers

    What happens to portal blood flow velocity during expiration according to the provided content?

    <p>Increases (C)</p> Signup and view all the answers

    Which of the following statements is true regarding the portal vein's role?

    <p>It serves as an insulating conduit from variable pressures. (D)</p> Signup and view all the answers

    What is a key characteristic of typical hepatic cysts?

    <p>They have thin and well-defined walls. (C)</p> Signup and view all the answers

    Which statement about nodular hyperplasia in older dogs is accurate?

    <p>It may occur in up to 70% of older dogs. (D)</p> Signup and view all the answers

    Why might nodular hyperplasia be difficult to detect on ultrasound?

    <p>It is often isoechoic to surrounding liver parenchyma. (A)</p> Signup and view all the answers

    What age range is associated with the earliest findings of nodules in dogs?

    <p>6 - 8 years old. (B)</p> Signup and view all the answers

    What type of cysts can be formed outside the biliary tract?

    <p>Acquired cysts. (D)</p> Signup and view all the answers

    What consistent feature may present at the proximal portion of hepatic cysts?

    <p>Reverberation artifacts. (C)</p> Signup and view all the answers

    How might the appearance of cysts vary according to their type?

    <p>They may vary from isoechoic to moderately hyperechoic. (A)</p> Signup and view all the answers

    What is NOT a characteristic of nodules associated with focal nodular hyperplasia?

    <p>They are always well-defined. (B)</p> Signup and view all the answers

    What is the most common primary hepatic tumor in dogs?

    <p>Hepatocellular carcinoma (A)</p> Signup and view all the answers

    Which imaging technique provides a more detailed evaluation of the liver?

    <p>CT scan (D)</p> Signup and view all the answers

    How much more common are metastatic liver tumors in dogs compared to primary hepatic tumors?

    <p>2.5 times more common (D)</p> Signup and view all the answers

    What characteristic is commonly associated with target lesions in the liver?

    <p>Hypoechoic rims and isoechoic centers (A)</p> Signup and view all the answers

    Which of the following does NOT typically produce target lesions?

    <p>Hemangioma (C)</p> Signup and view all the answers

    What positive predictive value is associated with finding one or more target lesions in the liver for malignancy?

    <p>74% (C)</p> Signup and view all the answers

    Which of the following tumors is the second most common primary hepatic tumor in dogs?

    <p>Benign cholangiocarcinoma (D)</p> Signup and view all the answers

    Which one of the following best characterizes primary liver tumors in cats?

    <p>More common than metastatic tumors (A)</p> Signup and view all the answers

    Which appearance is commonly associated with hepatocellular carcinoma?

    <p>Target lesion with a hypoechoic rim and hyperechoic center (A)</p> Signup and view all the answers

    Which type of neoplasia shows multiple focal hypoechoic nodules?

    <p>Lymphosarcoma (A)</p> Signup and view all the answers

    What is a characteristic feature of histiocytic sarcoma as seen in ultrasound images?

    <p>Focal hypoechoic masses (B)</p> Signup and view all the answers

    Which imaging finding is indicative of diffuse hepatic involvement?

    <p>Both hyperechoic and hypoechoic areas (B)</p> Signup and view all the answers

    Which of the following is a feature of cholangiocarcinoma as shown in ultrasound imaging?

    <p>Focal hypoechoic masses (D)</p> Signup and view all the answers

    What finding is typically associated with benign diseases that may mimic malignancy?

    <p>Target lesions in the liver (D)</p> Signup and view all the answers

    Which description best characterizes a focal irregular hyperechoic mass?

    <p>Can suggest malignancy (C)</p> Signup and view all the answers

    In ultrasound imaging, which of the following is a hallmark of hepatocellular carcinoma?

    <p>Target lesion with a characteristic appearance (D)</p> Signup and view all the answers

    Flashcards

    Abnormal Patent Ductus Venosus

    A patent ductus venosus detected after the first few weeks of life is considered abnormal, requiring confirmation with additional tests.

    Confirmation Methods

    Confirmation of an abnormal patent ductus venosus requires other tests like laboratory results, scintigraphy, or CT angiography.

    Normal Portal Blood Flow Velocity

    Normal portal blood flow velocity is slow and relatively uniform in the main portal vein, with small fluctuations.

    Portal Vein Insulation

    The portal vein is insulated from varying pressures and flows found in arteries and systemic veins due to its connection to intestinal capillaries and hepatic sinusoids.

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    Velocity Fluctuations Cause

    Small velocity fluctuations in the portal vein are believed to result from diaphragm respiratory movements.

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    Average Portal Blood Flow Velocity (Dogs)

    Average portal blood flow velocity in normal, unsedated dogs is typically around 18-19 cm/sec.

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    B-mode Image

    A B-mode image is a type of duplex image showing the internal structures like gallbladder, liver lobes, and hepatic veins.

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    Hepatic Vein Doppler

    A pulsed wave doppler image of the normal hepatic vein demonstrates its characteristics, like sample gate with angle correction.

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    Portal Vein Blood Flow Velocity (Dogs)

    The speed of blood flow in the portal vein of a dog, typically around 210-223 cm/sec.

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    Hepatic Arterial RI

    A measure of resistance in the hepatic artery, often used to evaluate liver blood flow in dogs and potentially in humans.

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    Mixed Echogenicity (Liver)

    Liver tissue that appears with a mix of different echo intensities (brightness levels) in an ultrasound image.

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    Target Lesions (Liver)

    Liver lesions with a hypoechoic (dark) rim and an isoechoic/hyperechoic (similar/lighter) center in an ultrasound image, often associated with neoplasia.

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    Portal Vein Thrombosis

    Blood clot within the portal vein, which can affect the flow of blood to the liver.

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    Normal Hepatic Arterial RI (Dogs)

    Average hepatic arterial resistance index in healthy dogs, typically around 0.68.

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    Color Doppler Imaging

    A type of ultrasound imaging that uses color to display blood flow direction.

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    Clinical Importance (Hepatic Arterial RI)

    The significance of measuring hepatic arterial resistance index (RI) in dogs in clinical practice is still under investigation. Results are not yet conclusive.

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    Ultrasound reliability for liver diagnosis

    Ultrasound imaging of the liver is not a reliable method for determining if liver disease is present or not. Microscopic evidence of disease might be present even if the ultrasound appears normal.

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    Portal Triads in Liver Biopsy

    Having a sufficient number of portal triads (structures within the liver) in a liver biopsy sample is crucial for accurate diagnosis. A range of 3 - 12 portal triads is sufficient, but optimal samples should have 12-15.

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    Liver Biopsy Technique

    Methods such as needle biopsies, laparoscopic procedures, or laparotomy can be used to collect liver biopsies. All should aim to collect a sufficient number of portal triads.

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    Pre-Biopsy prep

    Before doing a liver biopsy, the skin is cleaned and the area is prepared to ensure a clear view for the ultrasound.

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    Monitoring After Liver Biopsy

    Patients (or animals) should be closely monitored. Full recovery can take up to 24 hours to see the lowest Packed Cell Volume (PCV).

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    Hepatitis sample size

    Optimal liver biopsy samples for hepatitis assessment should contain at least 12-15 portal triads.

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    Copper Stain and Quantitation

    Adequate biopsy samples should allow for analysis of copper deposits in the liver to diagnose and measure copper levels properly.

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    Liver Biopsy and Coagulation

    The use of liver biopsies needs to be carefully evaluated in patients with abnormal blood clotting. Risk to benefit ratio needs to be studied.

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    Hepatic Cysts

    Hepatic cysts are characterized by thin walls, no internal echoes, sharp borders, and strong distal acoustic enhancement. They can be congenital or acquired.

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    Nodular Hyperplasia

    Nodular hyperplasia is a common benign liver condition, often seen in older dogs. Its appearance varies and may be similar to other liver issues on ultrasounds.

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    Isoechoic Lesions

    Isoechoic lesions have the same brightness as the surrounding liver tissue, making them difficult to detect in ultrasound images.

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    Ultrasound Detection Difficulty

    Nodular hyperplasia is often not easily seen on standard ultrasound due to its resemblance to the liver’s normal structure.

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    Distal Acoustic Enhancement

    Stronger-than-normal sound waves coming from behind a cyst.

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    Reverberation Artifacts

    Echoes from the cyst's wall that may look like irregularities, but are harmless.

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    Solitary/Multiple Cysts

    Hepatic cysts can occur as a single cyst or in multiple locations.

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    Acquired Cysts (Bilomas/Biliary Pseudocysts)

    Cysts outside the biliary tract, often forming from problems in this tract.

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    Metastatic Liver Tumors

    Tumors that spread to the liver from other parts of the body.

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    Primary Liver Tumors

    Tumors originating in the liver itself.

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    Hepatocellular Carcinoma (HCC)

    Most common primary liver tumor in dogs.

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    Target Lesions

    Liver nodules with a hypoechoic rim and an echo-genic or isoechoic center, often associated with malignancy.

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    Ultrasound & CT Scan Liver Evaluation

    Ultrasound is a readily available imaging method for liver evaluation although CT scans give more detailed views of the liver.

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    Malignant Liver Disease

    Can be detected with ultrasound by finding larger focal hepatic masses in dogs with peritoneal effusion.

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    Differentiation of Benign/Malignant Liver Lesions

    Ultrasound alone cannot directly determine if a focal liver lesion is benign or malignant. This might need additional assessment.

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    Positive Predicative Values of multiple Target Lesions

    Finding one or multiple target lesions in the liver or spleen can suggest a higher possibility of malignancy (74%-81%).

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    Hepatocellular Carcinoma (Dog/Cat)

    A type of liver cancer in dogs and cats, often appearing as target lesions or focal masses on ultrasound.

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    Target Lesion (Liver)

    A liver lesion with a dark (hypoechoic) rim and a bright (hyperechoic) center visible on ultrasound.

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    Focal Hypoechoic Mass (Liver)

    A localized, dark area in the liver seen on ultrasound imaging.

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    Diffuse Hepatic Involvement

    The liver is affected throughout, not just in a single area; seen on ultrasound.

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    Cholangiocarcinoma

    A cancer that arises from the bile ducts in the liver, sometimes visible on ultrasound.

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    Histiocytic Sarcoma (Liver)

    A type of cancer that originates from immune cells in the liver, visible as focal hypoechoic masses on ultrasound.

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    Lymphosarcoma (Liver)

    Cancer arising from lymphatic cells within the liver, appearing as multiple hypoechoic nodules on ultrasound.

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    Ultrasound Imaging (Liver)

    A diagnostic technique used to visualize liver structure and abnormalities.

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    Study Notes

    Liver Ultrasonography

    • Ultrasonography is a crucial imaging method for evaluating the liver, including the hepatic parenchyma, portal veins, hepatic veins, gallbladder, and biliary system.
    • Common indications include hepatomegaly, masses, suspected liver tumors (primary or metastatic), ascites, and unexplained increases in liver enzymes.
    • Other factors may necessitate liver imaging (e.g., protein-losing enteropathy, pancreatitis, hyperadrenocorticism).
    • Ultrasound guidance is used for percutaneous liver sampling (aspirates/biopsies) and monitoring disease response/progression.
    • Minimum sampling of two liver lobes is recommended in studies to identify disease.
    • Variation in diagnoses between two lobes is possible; correlating the biopsy findings with clinical information is important.
    • Cytologic and histologic diagnoses may not align with ultrasound findings. Ultrasound is not a diagnostic tool for cytology or histology.
    • Sufficient portal triad samples are crucial for accurate assessment. Biopsy techniques can typically achieve this; human criteria suggest 12-15 portal triads.
    • Copper stains are needed to accurately measure copper concentration in samples.
    • Culture of bile is more successful than liver samples for bacteria identification.
    • Laparoscopic biopsy balances adequate sample size, visualization, and minimally invasiveness.
    • Hemorrhage is the major complication. Check coagulation parameters (platelets, PT, PTT) prior to biopsy.
    • Precautions should be used in the presence of thrombocytopenia (<80,000/uL), especially in dogs.

    Technique

    • Complete abdominal examination is advisable (but only liver imaging is discussed).
    • Clip hair from the 10th intercostal space over the ventral abdomen and lateral walls.
    • Utilize acoustic gel for coupling with skin, or alcohol for cleaning.
    • Avoid stomach gas interference.
    • Dorsal or lateral recumbency positions are ideal for liver evaluation.
    • Transducer selection depends on the animal's size; 5.0 to 8.0 MHz microconvex transducer is suitable for most medium/large dogs; higher frequencies for smaller animals, 3.0 MHz for larger animals.
    • Systematic sequences of images are recommended, starting with the subxiphoid position and angling the beam.
    • Assess the caudate lobe along the right costal arch.
    • Intercostal windows (10th to 12th right/left spaces) can help visualize the liver, especially in animals with a small liver, stomach gas, or deep chest.
    • Right intercostal view is commonly needed to visualize the caudal vena cava, portal vein, common bile duct and lymph nodes in the porta hepatis region. A sector transducer is preferred for better fitting.

    Anatomy

    • The liver is bordered cranially by the diaphragm and ventrally by the falciform fat.
    • The liver is bordered by the right kidney, stomach, and spleen.
    • The curvilinear echogenic line is a reflection between the diaphragm and lung, representing the diaphragm.
    • Falciform fat (variable echogenicity) lies ventral to the liver.
    • Lobes include, left (lateral and medial), right (lateral and medial), quadrate, and caudate lobes.
    • Portal veins have bright, echogenic walls.
    • Hepatic veins appear as anechoic structures.
    • Hepatic veins connect into the caudal vena cava near the diaphragm.
    • Portal vein distribution differs from hepatic veins.
    • Hepatic arteries and bile duct branches aren't usually visible within the liver unless using Doppler ultrasonography.
    • Characteristics arterial signals allow locating the hepatic artery.

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