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Questions and Answers
Differentiate between communicating and non-communicating hydrocephalus based on their underlying mechanisms.
Differentiate between communicating and non-communicating hydrocephalus based on their underlying mechanisms.
Communicating hydrocephalus is caused by impaired CSF resorption, while non-communicating hydrocephalus results from obstruction of CSF flow within the ventricular system.
What are the typical CSF findings associated with acute bacterial meningitis, and how do they aid in distinguishing it from other forms of meningitis?
What are the typical CSF findings associated with acute bacterial meningitis, and how do they aid in distinguishing it from other forms of meningitis?
Typical CSF findings include increased pressure (>180 mm of water), a cloudy or frankly purulent appearance, elevated protein concentration (>50 mg/dL), markedly reduced glucose (<40 mg/dL), and a high neutrophil count, often as high as 90,000/µL. These findings help differentiate it from viral or fungal meningitis.
Describe the gross appearance of the subarachnoid space in tuberculous meningitis and explain how this contributes to the pathogenesis of associated neurological deficits.
Describe the gross appearance of the subarachnoid space in tuberculous meningitis and explain how this contributes to the pathogenesis of associated neurological deficits.
The subarachnoid space contains a greenish, gelatinous or fibrinous exudate, most prominent at the base of the brain and surrounding cranial nerves. This exudate can compress cranial nerves and obstruct CSF flow, leading to neurological deficits.
How does the presence of acid-fast bacilli in a brain tissue sample relate to the differential diagnosis of neurological infections, and what specific stains are used to identify them?
How does the presence of acid-fast bacilli in a brain tissue sample relate to the differential diagnosis of neurological infections, and what specific stains are used to identify them?
Explain the significance of Waterhouse-Friderichsen syndrome as a potential complication of meningitis, detailing its pathophysiology and typical clinical presentation.
Explain the significance of Waterhouse-Friderichsen syndrome as a potential complication of meningitis, detailing its pathophysiology and typical clinical presentation.
How do protozoal infections, such as toxoplasmosis or primary amoebic meningoencephalitis, cause encephalitis, and what distinguishes their mechanisms from viral or bacterial encephalitis?
How do protozoal infections, such as toxoplasmosis or primary amoebic meningoencephalitis, cause encephalitis, and what distinguishes their mechanisms from viral or bacterial encephalitis?
What are the main complications associated with bacterial meningitis?
What are the main complications associated with bacterial meningitis?
Describe the diagnostic significance of Kernig's and Brudzinski's signs in the clinical assessment of meningitis, and outline the anatomical basis for their elicitation.
Describe the diagnostic significance of Kernig's and Brudzinski's signs in the clinical assessment of meningitis, and outline the anatomical basis for their elicitation.
In cases of suspected encephalitis, what is the utility of CSF analysis in differentiating between viral and bacterial etiologies, and which specific CSF parameters are most informative?
In cases of suspected encephalitis, what is the utility of CSF analysis in differentiating between viral and bacterial etiologies, and which specific CSF parameters are most informative?
Explain the implications of increased protein and white blood cells with normal glucose levels in the cerebrospinal fluid of a patient presenting with fever, headache, and confusion.
Explain the implications of increased protein and white blood cells with normal glucose levels in the cerebrospinal fluid of a patient presenting with fever, headache, and confusion.
Flashcards
Hydrocephalus
Hydrocephalus
Excessive accumulation of CSF within the ventricular system, leading to dilated ventricles and increased intracranial pressure.
Causes of Hydrocephalus
Causes of Hydrocephalus
Caused by impaired CSF resorption or excessive CSF production.
Non-communicating hydrocephalus
Non-communicating hydrocephalus
Obstruction to CSF flow out of ventricles.
Hydrocephalus Clinical Features in infants
Hydrocephalus Clinical Features in infants
Separation of cranial sutures and head enlargement.
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Meningitis Definition
Meningitis Definition
Inflammation of the meninges, mainly in the subarachnoid space.
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Infectious Meningitis
Infectious Meningitis
Infection by microorganisms is the most common cause.
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Meningitis: Clinical Features
Meningitis: Clinical Features
Common symptoms are headaches, vomiting, fever, and convulsions. Neck stiffness indicates meningitis.
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CSF Examination (Meningitis)
CSF Examination (Meningitis)
Essential for meningitis diagnosis.
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CSF Appearance in Meningitis
CSF Appearance in Meningitis
Normally clear. Becomes cloudy/purulent in acute meningitis.
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WBCs in CSF (Meningitis)
WBCs in CSF (Meningitis)
In acute meningitis, neutrophils are most definitive.
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What is Game Theory?
- Involves mathematical models of strategic interactions among rational agents.
- Applicable to social science, logic, systems science, and computer science.
- Originated with John von Neumann's 1928 proof.
- Extensively developed in the 1950s, applied to political, economic, and military situations.
- "Game" signifies interaction where each player's outcome depends on decisions of others.
- Used to analyze various situations.
Example Games and Questions
- Auctions raise the question of how to bid.
- Routing asks how to avoid congestion.
- Social networks examine how to spread information.
- Economics considers how to set product prices.
- Security focuses on how to allocate limited resources to protect a target.
Selfish Routing (Roughgarden & Tardos)
- Model involves a network of $n$ nodes and $m$ edges.
- Each edge $e$ carries a cost function $\mathcal{L}_e(x)$, dependent on traffic amount.
- Flow represents traffic rate from source $s$ to target $t$.
Wardrop Equilibrium
- Traffic splits among paths ensuring all used paths have equal cost; unused paths have no less cost.
- A Wardrop equilibrium functions as a Nash equilibrium.
Braess's Paradox
- Adding network capacity can surprisingly increase average latency for users.
Price of Anarchy
- Measures the difference between Wardrop equilibrium and optimal routing.
- Formula: $PoA = \frac{\text{Cost of Wardrop Equilibrium}}{\text{Cost of Optimal Routing}}$
Mechanism Design
- Subfield of game theory focused on designing games to achieve a desired outcome despite self-interested players.
- Called "reverse game theory" due to starting with the outcome and designing the game backward.
Example
- Auctions ask how to maximize revenue for the seller.
- Voting examines how to design a system that reflects voters' preferences accurately.
- Task assignment considers how to maximize social welfare.
Revelation Principle
- In many settings, focusing on truthful mechanisms is sufficient, where players are incentivized to report true preferences.
- Simplifies mechanism design by focusing on truthful mechanisms.
VCG Mechanism
- A truthful mechanism that maximizes social welfare.
- Players pay the externality they impose on others.
- Widely used due to efficiency and truthfulness.
Review: Achievable Rate Region for Gaussian MAC
- For a Gaussian MAC, the equation is $Y = X_1 + X_2 + Z$ where $Z \sim \mathcal{N}(0, N)$.
- With power constraint $P_1, P_2$, the achievable rate region is the convex hull of rate pairs $(R_1, R_2)$.
- Rates must satisfy:
- $R_1 < I(X_1; Y|X_2) = \frac{1}{2}log(1 + \frac{P_1}{P_2 + N})$
- $R_2 < I(X_2; Y|X_1) = \frac{1}{2}log(1 + \frac{P_2}{P_1 + N})$
- $R_1 + R_2 < I(X_1, X_2; Y) = \frac{1}{2}log(1 + \frac{P_1 + P_2}{N})$
- Corner points are achieved by time-sharing.
- The capacity region is the achievable region.
Gaussian Broadcast Channel
- Given by:
- $Y_1 = X + Z_1$
- $Y_2 = X + Z_2$
- $Z_1 \sim \mathcal{N}(0, N_1)$, $Z_2 \sim \mathcal{N}(0, N_2)$
- Assume $N_1 \le N_2$, meaning user 1 is "better" than user 2.
- Independent messages should be sent to both users.
- Write $X = U + V$, allocate powers $P_U$ and $P_V$.
- Send information $W_2$ for user 2 in the "cloud" $U$ and $W_1$ for user 1 in $V$.
- User 2 decodes $W_2$ treating $V$ as noise.
- User 1 decodes $W_1$ after subtracting out $W_2$.
Encoding
- Codebook $\mathcal{C}_2$ for $W_2$: $U^n(W_2) \sim i.i.d. \mathcal{N}(0, P_U)$
- For each $U^n(w_2)$, generate a codebook $\mathcal{C}_1(w_2)$ for $W_1$: $V^n(w_1) \sim i.i.d. \mathcal{N}(0, P_V)$
- $X^n = U^n(w_2) + V^n(w_1)$.
Decoding
- User 2 decodes $W_2$, finding $\hat{W}_2$ such that $(U^n(\hat{W}2), Y_2^n) \in A{\epsilon}^{(n)}$.
- Declared $\hat{W}_2$ if unique. Achievable rate: $R_2 < I(U; Y_2) = \frac{1}{2}log(1 + \frac{P_U}{P_V + N_2})$.
- User 1 subtracts out $U^n(\hat{w}_2)$ and decodes $W_1$: look for $\hat{W}_1$ such that $(V^n(\hat{W}_1), Y_1^n - U^n(\hat{W}2)) \in A{\epsilon}^{(n)}$
- Declared $\hat{W}_1$ if unique.
- Achievable rate: $R_1 < I(V; Y_1|U) = \frac{1}{2}log(1 + \frac{P_V}{N_1})$.
Inner Bound
- Shown visually in a rate region diagram.
Capacity Region
- Capacity region is the closure of rate pairs $(R_1, R_2)$.
- Rates must satisfy:
- $R_1 \le \frac{1}{2}log(1 + \frac{\alpha P}{N_1})$
- $R_2 \le \frac{1}{2}log(1 + \frac{(1 - \alpha)P}{\alpha P + N_2})$
- For some $0 \le \alpha \le 1$.
- Choose $P_V = \alpha P$ and $P_U = (1 - \alpha)P$.
Why is superposition coding optimal?
- Key idea: Successive refinement of information.
- $X \longrightarrow Y_1 \longrightarrow Y_2$
- Degradedness: $I(X; Y_1) \ge I(X; Y_2), \forall P_X$
- For information to $Y_2$, full resolution (required by $Y_1$) is unnecessary.
Duality
- Relates Broadcast Channel and Multiple Access Channel.
Broadcast Channel
- One encoder sends messages to multiple decoders.
Multiple Access Channel
- Multiple encoders send messages to one decoder.
- Roles of encoder and decoder are swapped.
- Message $W_i$ becomes side information $U_i$.
Análisis de Algoritmos
- Orden de Complejidad Asintótica describes the limit of an algorithm when the size of the input becomes infinitely larger.
Notación Big-O
- $O(g(n))$ defines the set of functions that grow no faster than $g(n)$, where $n$ is the size of the input.
Notación Omega
- $\Omega(g(n))$ defines the set of functions that grow no slower than $g(n)$.
Notación Theta
- $\Theta(g(n))$ defines the set of functions that grow at the same rate as $g(n)$.
Clases de Complejidad Comunes
- $O(1)$ or Constant, can be exemplified by accessing an array element via its index.
- $O(log n)$ or Logarithmic, can be exemplified by a binary search in a sorted array.
- $O(n)$ or Linear, can be exemplified by a search within an unsorted Array.
- $O(n log n)$ or Linear-Logarithmic, can be exemplified by efficient sequencing algorithms (merge sort).
- $O(n^2)$ or Quadratic, can be exemplified by bubble sequencing.
- $O(n^3)$ or Cubic, can be exemplified by matrix multiplication.
- $O(2^n)$ or Exponential, can be exemplified by a traveler dilemma.
- $O(n!)$ or Factorial, can be exemplified by creating complete list specifications.
Análisis de Bucles
- Bucle Simple: The complexity is the number of times the loop runs multiplied by the complexity of the operations within the loop.
- Bucles Anidados: The complexity is the product of the number of iterations of all loops.
Análisis de Recursión
- Recursion algorithms' complexity are determined with recurrence relations.
- The recurrence relation for binary search is $T(n) = T(n/2) + O(1)$.
- Solutions are $T(n) = O(log n)$.
Example of Code (Python)
def linear_search(arr, target):
"""
Looks for a goal in an array.
"""
for i in range(len(arr)):
if arr[i] == target:
return i # Returns index if located.
return -1 # Returns -1 if not located.
- Complexity: $O(n)$ in the worst case, where $n$ is the length of the array.
Tips for Improving Complexity
- Efficient data structures should be used such as tables and hash search trees.
- Apply divide and win algorithms.
- Avoid redundant calculations by memorization.
Warning
- Asymptotic complexity analysis provides performance information lacking important constants and factors for low order small entry sizes.
What is Algorithmic Trading
- Uses computer programs to follow an algorithm for placing a trade.
- Algorithms consider timing, price, quantity, and mathematical models.
- Widely used by investment banks, pension funds, hedge funds, and other institutional traders.
Why do Algo Trading?
- Minimizes transaction costs and improves order execution speed.
- Takes advantage of arbitrage and diversifies trading.
- Allows backtesting and reduces human error.
Types of Strategies
Trend Following
- Identifies and capitalizes on existing market trends.
- Uses moving averages or technical indicators to identify trends and execute trades accordingly.
Mean Reversion
- Identifies deviations from the average asset price.
- Executes trades based on the expectation that price reverts to its mean level.
- Relies on statistical analysis and probability.
Arbitrage
- Exploits price differences for the same asset in different markets.
- Identifies price differences, buys cheaper assets, and sells more expensive ones simultaneously.
- Aims to generate risk-free profits from temporary mispricing.
Index Fund Trading
- Replicates performance of a specific market index like the S&P 500.
- Automatically buys and sells stocks in proportion to the index's holdings.
- Implements a low-cost, passive investment strategy.
Mathematical Model Based
- Identifies trading opportunities using sophisticated mathematical models.
- Models incorporate statistical analysis, econometric modeling, and machine learning.
How to get Started with Algorithmic Trading
- Learn Python programming language.
- Establish a brokerage account with API access via Interactive Brokers or Alpaca.
- Find a data provider like Polygon or IEX Cloud.
- Develop and backtest the algorithm using historical data for refinement.
- Automate the algorithm and monitor its performance.
Conclusion
- Algorithmic trading is a tool that improves trading.
- Understand risks before using algorithmic trading.
- Can be a valuable asset with planning and execution.
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