Podcast
Questions and Answers
Which substance is considered safe for patients with G6PD deficiency?
Which substance is considered safe for patients with G6PD deficiency?
What effect does increased 2,3-BPG have on hemoglobin?
What effect does increased 2,3-BPG have on hemoglobin?
Which of the following factors does NOT affect hemoglobin affinity for oxygen?
Which of the following factors does NOT affect hemoglobin affinity for oxygen?
Which substance is explicitly noted as a substance to avoid for G6PD deficiency patients?
Which substance is explicitly noted as a substance to avoid for G6PD deficiency patients?
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What is the primary role of the Methemoglobin Reductase Pathway?
What is the primary role of the Methemoglobin Reductase Pathway?
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Study Notes
G6PD Deficiency and Hemolysis
- Drugs, chemicals, and foods can cause hemolysis in G6PD deficiency patients.
- Avoid these: Dapsone, Methylthioninium chloride (methylene blue), Nitrofurantoin, Phenazopyridine, Primaquine, Rasburicase, Tolonium chloride (toluidine blue), Aniline dyes, Fava beans, Red wine, Legumes (e.g., garbanzos, kadyos).
- Certain foods can trigger hemolysis, including: munggo, Blueberry, Soya food (e.g., taho, tokwa, soy sauce), Ampalaya (bitter gourd or bitter melon), Menthol (e.g., mouthwash), Efficascent Oil, Listerine, Cotrimoxazole, Quinolones, Sulfadiazine, Naphthalene (mothballs), Some herbal supplements.
Methemoglobin Reductase Pathway
- Maintains the iron in hemoglobin in its ferrous/reduced state (Fe2+).
- Protects the heme portion of hemoglobin.
Rapoport-Luebering Shunt
- Produces 2,3-BPG.
- 2,3-BPG binds to hemoglobin and decreases oxygen affinity, promoting oxygen release to tissues.
Factors Affecting Hemoglobin's Affinity for Oxygen
- Five factors affect the affinity of hemoglobin for oxygen:
- pH
- Partial pressure of carbon dioxide
- Concentration of 2,3-bisphosphoglycerate (2,3-BPG)
- Temperature
- Presence of other nonfunctional hemoglobin species.
- Higher 2,3-BPG concentration means more oxygen is released to tissues.
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Description
Test your understanding of G6PD deficiency and the various factors that can trigger hemolysis in affected individuals. This quiz covers related pathways and drugs, foods, and chemicals that are contraindicated for patients with G6PD deficiency. Additionally, explore the importance of the Rapoport-Luebering shunt in oxygen delivery.
