Future Directions in Pharmacotherapeutics for Erectile Dysfunction
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Questions and Answers

What is one of the main potential advances in the treatment of ED according to the text?

  • Promising results of Avanafil in Phase III trials
  • Understanding of the pathophysiology of the disorder (correct)
  • Introduction of PDE5 inhibitors
  • Development of drugs targeting unrelated physiological pathways

Which medication, currently available in Asia, shows promising safety and efficacy data for treating ED?

  • Sildenafil
  • Apomorphine
  • Udenafil (correct)
  • Vardenafil

What physiological pathway has been shown to improve erectile function in animal models of diabetes according to the text?

  • Serotonin pathway
  • Dopamine pathway
  • Oxytocin pathway
  • RhoA/Rho kinase pathway (correct)

What was the future use of apomorphine described as in the text?

<p>Uncertain with mixed results from clinical trials (C)</p> Signup and view all the answers

What does Avanafil show promising results in, based on early Phase I/II trials?

<p>Determining dose tolerability and safety in patients (A)</p> Signup and view all the answers

Which statement best describes the advancements in oral treatment for ED since the introduction of PDE5 inhibitors?

<p>No significant advancements have occurred since the introduction of PDE5 inhibitors over 10 years ago (A)</p> Signup and view all the answers

What is considered the most direct route to improved pharmacotherapeutics for erectile dysfunction?

<p>Development of selective PDE isozyme inhibitors (A)</p> Signup and view all the answers

Why are gene therapy and cell-based treatments not expected to become standard treatments for ED in the near future?

<p>Their limitations and advancements in understanding ED molecular mechanisms (D)</p> Signup and view all the answers

What is a key feature desired in the ideal improvement for treating erectile dysfunction?

<p>Non-invasive with minimal side-effects (C)</p> Signup and view all the answers

Why is there a growing dissatisfaction with the use of current PDE-5 inhibitors to treat ED?

<p>Failure correlated with expectations (A)</p> Signup and view all the answers

Which group of men is less effectively treated by oral PDE-5 inhibitor therapy due to severe affliction?

<p>Men with organic ED who are more severely afflicted (B)</p> Signup and view all the answers

What is the main emphasis when discussing potential advancements in treating neurogenic ED?

<p>Understanding molecular basis and pathophysiology of ED (C)</p> Signup and view all the answers

Why is age-associated ED becoming an increasing area of interest?

<p>'Men remain sexually active into old age' (D)</p> Signup and view all the answers

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