Future Directions in Pharmacotherapeutics for Erectile Dysfunction
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Questions and Answers

What is one of the main potential advances in the treatment of ED according to the text?

  • Promising results of Avanafil in Phase III trials
  • Understanding of the pathophysiology of the disorder (correct)
  • Introduction of PDE5 inhibitors
  • Development of drugs targeting unrelated physiological pathways
  • Which medication, currently available in Asia, shows promising safety and efficacy data for treating ED?

  • Sildenafil
  • Apomorphine
  • Udenafil (correct)
  • Vardenafil
  • What physiological pathway has been shown to improve erectile function in animal models of diabetes according to the text?

  • Serotonin pathway
  • Dopamine pathway
  • Oxytocin pathway
  • RhoA/Rho kinase pathway (correct)
  • What was the future use of apomorphine described as in the text?

    <p>Uncertain with mixed results from clinical trials</p> Signup and view all the answers

    What does Avanafil show promising results in, based on early Phase I/II trials?

    <p>Determining dose tolerability and safety in patients</p> Signup and view all the answers

    Which statement best describes the advancements in oral treatment for ED since the introduction of PDE5 inhibitors?

    <p>No significant advancements have occurred since the introduction of PDE5 inhibitors over 10 years ago</p> Signup and view all the answers

    What is considered the most direct route to improved pharmacotherapeutics for erectile dysfunction?

    <p>Development of selective PDE isozyme inhibitors</p> Signup and view all the answers

    Why are gene therapy and cell-based treatments not expected to become standard treatments for ED in the near future?

    <p>Their limitations and advancements in understanding ED molecular mechanisms</p> Signup and view all the answers

    What is a key feature desired in the ideal improvement for treating erectile dysfunction?

    <p>Non-invasive with minimal side-effects</p> Signup and view all the answers

    Why is there a growing dissatisfaction with the use of current PDE-5 inhibitors to treat ED?

    <p>Failure correlated with expectations</p> Signup and view all the answers

    Which group of men is less effectively treated by oral PDE-5 inhibitor therapy due to severe affliction?

    <p>Men with organic ED who are more severely afflicted</p> Signup and view all the answers

    What is the main emphasis when discussing potential advancements in treating neurogenic ED?

    <p>Understanding molecular basis and pathophysiology of ED</p> Signup and view all the answers

    Why is age-associated ED becoming an increasing area of interest?

    <p>'Men remain sexually active into old age'</p> Signup and view all the answers

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