40 Questions
Which glands produce androgens in the human body?
Testes, ovaries, and adrenal cortex
What is the primary clinical application of androgens in males?
Managing androgen deficiency
How does testosterone production change with age in men?
Starts declining after 30-40 years old
What regulates the production of testosterone in males?
Negative feedback control from rising testosterone levels
What is the significance of Leydig cells in testosterone production?
They produce testosterone in the testes
What is the principal disadvantage of testosterone gels compared to patches?
Testosterone can be transferred to others by skin-to-skin contact.
What is a major concern related to the transfer of testosterone gels to women and children?
Risk of virilization and fetal harm
Which androgen replacement therapy is specifically formulated for underarm application?
Axiron liquid
What should gel users do to reduce the risk of unintended gel transfer to others?
Wash hands after every application and cover the site with clothing
How long does it take for blood levels of testosterone topical solution to reach steady-state after regular application?
14 days
What is the recommended dosage for testosterone buccal tablets (Striant)?
1 tablet every 12 hours
Which side effect is NOT commonly associated with androgen use?
Hypotension
Why should patients with nasal disorders or abnormalities avoid using Testosterone nasal gel (Natesto)?
It can worsen their nasal condition
What is the major concern with the long-acting IM testosterone esters (testosterone cypionate and testosterone enanthate) regarding blood levels of testosterone?
They have unstable blood levels of testosterone
What is a significant risk associated with androgen use by athletes?
Accelerated atherosclerosis
What is the primary hormone that regulates the synthesis of preandrogens by the adrenal glands in women?
Adrenocorticotropic hormone
Which of the following statements about testosterone production is true?
In females, about 300 micrograms of testosterone are produced daily.
What is the primary effect of testosterone on bone growth?
Promoting growth of bone and skeletal muscle
Which of the following is a potential consequence of excessive androgen production in females?
Virilization
What did the US Food and Drug Administration (FDA) emphasize regarding testosterone use in 2018?
Lowered testosterone due to aging was not a concern.
Which of the following is NOT an adverse effect of testosterone therapy?
Decrease in glandular breast tissue
What is the incidence of erectile dysfunction (ED) among men with diabetes?
Between 35% and 75%
Which drug for erectile dysfunction is preferred according to current guidelines?
Sildenafil
What is a common adverse effect of sildenafil (Viagra) for erectile dysfunction?
Hearing loss
What are the characteristics associated with the abuse of anabolic steroids?
Increased muscle mass and strength
In what year was sildenafil approved as Revatio for pulmonary arterial hypertension?
2005
Why are anabolic steroids classified as Schedule III substances?
Based on their abuse potential
What is the primary therapeutic goal of managing hypogonadism through testosterone supplementation?
To manage testosterone deficiency
What adverse effect can androgens have on children's growth?
Accelerated bone maturation
What is the goal of hormone therapy for transgender men?
To stop menstruation and develop male secondary sex characteristics
Which drug for erectile dysfunction has the shortest duration of action?
Avanafil
What is the maximum recommended dose of Vardenafil for erectile dysfunction?
20 mg
What is the main adverse effect associated with Alprostadil administration for erectile dysfunction?
Priapism
Which drug is used off-label for premature ejaculation treatment among the given choices?
Clomipramine
What is the ideal concentration of papaverine in the injection therapy for erectile dysfunction?
30 mg/mL
Which drug class is most appropriate for men with very large prostates in the treatment of BPH?
5-α-reductase inhibitors
What is a common side effect associated with 5-α-reductase inhibitors used in BPH treatment?
Decreased ejaculate volume
Which of the following medications can cause abnormal ejaculation in BPH patients?
Silodosin
Why are nonselective α1 blockers like doxazosin and terazosin particularly useful for some patients with BPH?
They promote vasodilation
In what situation should caution be exercised when prescribing nonselective α blockers for BPH treatment?
In patients with low blood pressure
Test your knowledge on the dosages and timing of popular medications for erectile dysfunction, including sildenafil, vardenafil, tadalafil, and avanafil. Learn about the recommended doses and duration of effects for each drug.
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