Fungal Infections and Dermatophytes Quiz
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Questions and Answers

Which type of fungi is characterized by being multicellular and growing best at 25°C?

  • Mold (correct)
  • Dimorphic fungi
  • Yeast
  • Superficial fungi
  • What is the clinical name for the infection caused by dermatophytes in keratinized structures?

  • Tinea incognito
  • Dermatophytosis (correct)
  • Tinea unguium
  • Ringworm
  • Which dermatophyte primarily infects humans and is transmitted between individuals?

  • Geophilic
  • Arthropophilic (correct)
  • Zoophilic
  • Thermally dimorphic
  • Which form of tinea corporis is typically associated with contact sports such as wrestling?

    <p>Tinea gladiatorum (C)</p> Signup and view all the answers

    What is a distinguishing feature of tinea corporis caused by M.canis following contact with kittens?

    <p>Circinate lesions (D)</p> Signup and view all the answers

    Which type of dermatophyte is usually responsible for causing tinea imbricata?

    <p>Trichophyton (D)</p> Signup and view all the answers

    How does the infection of dermatophytes typically progress in the skin?

    <p>In a circular pattern with central clearing (B)</p> Signup and view all the answers

    What impact do topical steroid applications have on tinea incognito?

    <p>Alter morphology and thin the skin (C)</p> Signup and view all the answers

    Which investigation is primarily indicated to confirm the presence of oropharyngeal candidiasis?

    <p>KOH mount showing budding yeast and pseudohyphae (A)</p> Signup and view all the answers

    What is the mode of action for flucytosine in antifungal therapy?

    <p>Interference with nucleic acid synthesis (D)</p> Signup and view all the answers

    Which of the following is a common clinical manifestation of cutaneous candidiasis?

    <p>Paronychia (D)</p> Signup and view all the answers

    What should be done to manage chronic paronychia effectively?

    <p>Keep hands warm and dry (D)</p> Signup and view all the answers

    Which antifungal drug class is known to inhibit the cytochrome P450 enzyme involved in ergosterol biosynthesis?

    <p>Azoles (C)</p> Signup and view all the answers

    Which of the following is characterized by the presence of yellow cup-shaped crusts and is caused by T. schoenleinii?

    <p>Favus (A)</p> Signup and view all the answers

    Which clinical type of Tinea pedis is characterized by scaling, fissuring, or erythema between the third and fourth toes?

    <p>Interdigital type (C)</p> Signup and view all the answers

    What is the primary cause of Tinea Pedis, also known as athlete's foot?

    <p>T.rubrum (A)</p> Signup and view all the answers

    What is the primary causative agent of Pityriasis (Tinea) Versicolor?

    <p>Malassezia furfur (D)</p> Signup and view all the answers

    What is a characteristic feature of hyperkeratotic Tinea pedis?

    <p>Scaling of the planter surface (D)</p> Signup and view all the answers

    What type of dermatophyte infection would most likely be experienced by animal handlers and is characterized by intense inflammation?

    <p>Tinea Barbae (C)</p> Signup and view all the answers

    Which variant of Tinea Capitis results in partial alopecia covered with grayish-white scales?

    <p>Gray patch Tinea Capitis (C)</p> Signup and view all the answers

    Which KOH smear appearance is characteristic of Pityriasis Versicolor?

    <p>Spaghetti and meatballs appearance (C)</p> Signup and view all the answers

    Which agent commonly causes superficial white onychomycosis?

    <p>Fusarium (B)</p> Signup and view all the answers

    What is the primary predisposing factor for Tinea Cruris?

    <p>Warm weather (B)</p> Signup and view all the answers

    What is the most common site for lesions in Pityriasis Versicolor?

    <p>Back and upper arms (C)</p> Signup and view all the answers

    What condition can result from treatment of a fungal infection with topical steroids?

    <p>Tinea incognito (D)</p> Signup and view all the answers

    Which of the following treatments is effective against Pityriasis Versicolor?

    <p>Selenium sulphate (B)</p> Signup and view all the answers

    Fibrous animal ringworm of the scalp can lead to which of the following complications?

    <p>Permanently scarred alopecia (B)</p> Signup and view all the answers

    Which reaction occurs as a systemic response to fungal antigens in cases of inflammatory Tinea Capitis?

    <p>Dermatophytid 'id' reaction (B)</p> Signup and view all the answers

    Which investigation method is used to detect dermatophyte infections?

    <p>KOH mount of skin scraping (B)</p> Signup and view all the answers

    Griseofulvin is prescribed at a dosage of 12.5 mg/kg for which condition?

    <p>Tinea corporis (B)</p> Signup and view all the answers

    What is the common presentation of Tinea Manuum?

    <p>Scaling and maceration between fingers (B)</p> Signup and view all the answers

    In which area would you differentiate erythema from tinea?

    <p>Feet (D)</p> Signup and view all the answers

    What is the typical duration for systemic Terbinafine treatment in cases of tinea cruris?

    <p>2 weeks (B)</p> Signup and view all the answers

    Which variant of Tinea Capitis is most often associated with dermatophytes of animal origin?

    <p>Kerion (B)</p> Signup and view all the answers

    The increase of which factors can predispose an individual to Candidiasis?

    <p>Immune disorders and antibiotic use (A)</p> Signup and view all the answers

    Which condition is primarily a dermatophytosis of the groin and is most common in men?

    <p>Tinea Cruris (B)</p> Signup and view all the answers

    Tinea unguium typically affects which part of the body?

    <p>Nail plate (A)</p> Signup and view all the answers

    Which of the following conditions can masquerade as a dermatophyte infection due to misuse of treatment?

    <p>Tinea incognito (C)</p> Signup and view all the answers

    Which of the following symptoms is NOT typically associated with Tinea Pedis?

    <p>Pustules (C)</p> Signup and view all the answers

    Which demographic is most likely to experience Pityriasis Versicolor?

    <p>Adolescent and young adult males (C)</p> Signup and view all the answers

    What is a major identifying feature of vesiculobullous Tinea pedis?

    <p>Pruritic vesicles and bullae (D)</p> Signup and view all the answers

    What is a common environmental condition associated with Pityriasis Versicolor?

    <p>Hot and humid climate (A)</p> Signup and view all the answers

    Which antigungal agent is known to be effective for superficial fungal infections like Tinea?

    <p>Clotrimazole (A)</p> Signup and view all the answers

    Flashcards

    Dermatophytosis

    A fungal infection that affects the keratinized structures of the skin, nails, and hair shafts.

    Arthropophilic dermatophyte

    A type of fungus that commonly infects humans and is easily spread from person to person.

    Zoophilic dermatophyte

    A type of fungus that typically infects animals but can be transmitted to humans.

    Geophilic dermatophyte

    A type of fungus that primarily lives in soil and can infect humans through contact with contaminated soil.

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    Tinea capitis

    A fungal infection of the scalp.

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    Tinea barbae

    A fungal infection of the beard and moustache.

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    Tinea corporis

    A common fungal infection of the body that is characterized by round, reddish patches with a raised, active border.

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    Tinea pedis

    A fungal infection of the feet, commonly called athlete's foot.

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    Candidiasis

    A fungal infection that affects the skin, mucous membranes, and nails, often caused by Candida albicans.

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    Oral Thrush

    A common type of candidiasis that affects the mouth, causing white patches, soreness, and sometimes difficulty swallowing.

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    Intertrigo

    A type of candidiasis that affects the skin folds, causing redness, itching, and often a moist rash.

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    Onychomycosis

    A fungal infection of the nails, often causing thickening, discoloration, and separation of the nail from the nail bed.

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    Paronychia

    A fungal infection of the skin that often affects the hands, causing redness, swelling, and pain around the nail.

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    Interdigital Tinea Pedis

    A type of tinea pedis characterized by scaling, fissuring, or erythema between the toes, particularly in the 3rd & 4th toe clefts.

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    Hyperkeratotic (Moccasin-Type) Tinea Pedis

    A type of tinea pedis involving scaling on the plantar surface and sides of the feet, resembling the pattern of a moccasin.

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    Vesiculobullous Tinea Pedis

    A type of tinea pedis caused by Trichophyton mentagrophytes, featuring pruritic, tense vesicles and bullae affecting the entire soles. Often associated with the moccasin type.

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    Tinea Pedis (T. rubrum)

    Tinea pedis caused by T. rubrum, characterized by mild maceration under the little toe and more extensive maceration of all toe web spaces. It may show sub-clinical infection.

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    Tinea Unguium

    A fungal infection of the nails, also known as Dermatophyte Onychomycosis, often caused by Trichophyton species.

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    Distal and Lateral Subungual Onychomycosis

    A type of tinea unguium where the nail lifts up from the nail bed and crumbles at the free edge. Usually caused by T. rubrum.

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    Superficial White Onychomycosis

    A type of tinea unguium characterized by flaky white patches on the surface of the nail plate. Can be caused by different fungi like T. mentagrophytes, Aspergillus, Fusarium, and Acremonium.

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    Proximal White Subungual Onychomycosis

    A type of tinea unguium that affects the nail bed and can lead to white discoloration under the nail. Associated with HIV.

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    Fierce Animal Ringworm of the Scalp

    A chronic, severe fungal infection of the scalp that can cause permanent hair loss (alopecia).

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    Tinea Incognito

    A condition where the usual appearance of a fungal infection is masked by the application of topical steroids.

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    What is Tinea Cruris?

    A fungal infection of the groin, often seen in men, with a tendency to spread to the inner thighs and buttocks. It rarely affects the scrotum, unlike yeast infections.

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    What is Tinea Capitis?

    A fungal infection of the scalp that can exist in two forms: non-inflammatory, characterized by scaly patches and hair breakage, and inflammatory, causing swelling, crusting, and hair loss.

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    Explain Kerion.

    A type of inflammatory tinea capitis caused by dermatophytes of animal origin, leading to boggy swelling and inflammation on the scalp.

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    What is Favus?

    A severe form of scalp infection caused by a specific fungus (Trichophyton schoenleinii), characterized by yellow cup-shaped crusts and distinctive hair shaft features.

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    What are Dermatophytid 'id' Reactions?

    A reaction to fungal infection on the body caused by a systemic response to fungal antigens. It often appears as itchy, raised bumps and rashes on the trunk and extremities.

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    What is Tinea Barbae?

    A fungal infection of the beard and moustache, often seen in individuals who work closely with animals, such as ranchers or farmers.

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    What is Tinea Manuum?

    A fungal infection of the hands, typically caused by contact with animals harboring zoophilic fungi. It often presents with scaling, redness, and pustules.

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    What is Tinea Pedis?

    A fungal infection of the feet, commonly called athlete's foot, primarily caused by two common fungi. It typically causes scaling, maceration, and itching between the toes.

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    What are Zoophilic Dermatophytes?

    Fungi that typically infect animals but can be transmitted to humans, often causing infections such as Tinea barbae or Tinea manuum.

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    What are Zoophilic Dermatophyte Infections?

    A type of fungal infection caused by zoophilic dermatophytes, commonly seen in individuals who work with or have contact with animals.

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    What is Pityriasis versicolor?

    A chronic, superficial fungal infection of the skin caused by the lipophilic yeast Malassezia furfur and Malassezia globosa. It is characterized by small, hypopigmented or hyperpigmented macules that are usually asymptomatic.

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    Where does Pityriasis versicolor usually appear?

    The most common sites of Pityriasis versicolor are the back, underarms, upper arms, chest, and neck.

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    Who is most likely to get Pityriasis versicolor?

    Pityriasis versicolor is most prevalent in adolescents and young adults, especially males. It is also linked to hot and humid climates and increased sweating.

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    What is Candidiasis?

    A fungal infection of the skin that is caused by the yeast Candida albicans. It is often called a yeast infection.

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    What factors can increase the risk of Candidiasis?

    Infancy, pregnancy, old age, disorders of immune function (e.g., leukemia, corticosteroid therapy), chemotherapy, endocrine disorders (e.g., diabetes mellitus), and carcinoma can all increase the risk of candidiasis.

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    What factors can make Candida albicans pathogenic?

    Candida albicans, a normally harmless commensal organism, can become pathogenic under certain conditions. These include diabetes, other endocrine disorders, and antibiotic use.

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    How is Pityriasis versicolor diagnosed?

    The diagnosis of Pityriasis versicolor is typically based on clinical presentation, KOH smear examination, and Wood lamp examination.

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    What is seen in a KOH smear examination for Pityriasis versicolor?

    KOH smear examination shows "spaghetti and meatballs" like appearance under the microscope.

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    What does a Wood lamp examination show in Pityriasis versicolor?

    Wood lamp examination reveals a yellow-orange fluorescence in the lesions of Pityriasis versicolor.

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    How is Pityriasis versicolor treated?

    Anti-fungal creams, lotions, or shampoos containing agents like ketoconazole, terbinafine, and selenium sulfide are typically effective in treating Pityriasis Versicolor.

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    Study Notes

    Fungal Skin Infections

    • Fungal skin infections, also known as mycoses, are infections caused by fungi.
    • Fungi are classified into three main types: unicellular yeast (37°C), multicellular mold (25°C), and dimorphic fungi (mold→yeast).
    • The skin structure includes the epidermis, dermis, and subcutaneous layer. Hair follicles, sebaceous glands, and sweat glands are also found in the skin.
    • Superficial mycoses infect various superficial skin structures including hair, nails, and stratum corneum. Dermatophytoses (ringworm) is a common superficial infection.
    • Dermatophytes are classified as geophilic (live in soil), zoophilic (infect animals which can spread to humans), and anthropophilic (infect humans and spread person-to-person).
    • Dermatophytosis (ringworm) is the infection of keratinized structures (hair, nails, stratum corneum) by dermatophytes. The three main types of dermatophytes are Trichophyton, Epidermophyton, and Microsporum
    • Dermatophyte infections spread in a centrifugal pattern, creating ring-shaped lesions.
    • Common clinical forms of tinea corporis include tinea capitis (scalp), tinea barbae (beard and mustache), tinea facialis (face), and tinea corporis (body), tinea cruris (groin), tinea manuum (hands), tinea pedis (feet), tinea unguium (nails), tinea incognito.
    • All dermatophytes can cause lesions on glabrous skin (smooth skin). Typical lesions include annular raised edges (active border), and a clearing center, covered with papules, vesicles, and pustules.
    • Tinea corporis (body ringworm) is often caused by M. canis and can be acquired from infected animals. Different clinical variants exist including circinate lesions, tinea gladiatorum, tinea imbricata, tinea incognito, and majocchi granuloma
    • Tinea cruris ("jock itch") is a dermatophyte infection of the groin that involves the upper medial thigh, buttock, and pubic area. It is less common to infect the scrotum. Predisposing factors include warm, moist environments and sweating.
    • Tinea capitis is a fungal infection of the scalp. It can be non-inflammatory (grey patch or black dot) or inflammatory (kerion).
    • Tinea pedis (athlete's foot) is caused by T. rubrum or T. mentagrophytes, characterized by scaling, maceration, and itching between the toes, especially the fourth interdigital space. Common clinical types include interdigital, hyperkeratotic, and vesiculobullous.
    • Tinea unguium (nail fungus) is a dermatophyte infection of the nails commonly caused by Trichophyton sp. It can present as distal/lateral subungual onychomycosis(nail lifts up, free end crumbles), superficial white onychomycosis(white patches on nail), and proximal white onychomycosis

    Pityriasis Versicolor

    • A chronic superficial fungal disease of the skin caused by lipophilic yeast Malassezia furfur and Malassezia globosa.
    • Lesions are asymptomatic, small, hypopigmented or hyperpigmented macules. Common sites include back, underarm, upper arm, chest, and neck; typically seen in adolescent and young adult males
    • Associated with hot and humid climates and increased sweating.
    • Diagnosis involves clinical presentation, KOH mount examination ('spaghetti and meatballs'), and Wood's lamp examination (yellow-orange fluorescence).
    • Treatment includes antifungal creams, lotions, or shampoos (e.g., ketoconazole, terbinafine, selenium sulfide) that are usually effective but may cause ongoing skin discoloration for weeks to months

    Candidiasis

    • Candidiasis of skin, mucous membranes, and nails.
    • Predisposing factors include infancy, pregnancy, old age, immune disorders (e.g., leukemia), corticosteroid therapy, chemotherapy, immunosuppressive drugs, antibiotic use, and endocrine disorders (e.g., diabetes), and carcinoma.
    • Common clinical forms include thrush, vulvovaginitis, intertrigo, diaper, perineal, and paronychia candidiasis.
    • Diagnosis involves KOH mounts (budding yeasts , pseudohyphae), cultures, and urine sugar testing (if indicated).
    • Treatment involves controlling predisposing factors (eliminating antibiotics, controlling moisture, etc.). Antifungal creams, topical drugs (e.g., nystatin), oral suspensions, or oral and topical antibitiocs are typically used, alongside specific management of each clinical form.

    Investigations for Fungal Skin Infections

    • Microscopic examination of skin scrapings or nail clippings, using KOH mounts
    • Cultures using appropriate media
    • Wood's lamp exam for specific types of infections (e.g., Pityriasis versicolor)

    Antifungal Therapy

    • Antifungal therapies are classified by their site of action, these types include:
      • Nuclear level: Flucytosine
      • Cytoplasmic membrane level: Polyenes (e.g., Nystatin, Amphotericin B), Azoles (e.g., imidazole, ketoconazole, itraconazole, fluconazole), and Allaylamines (e.g., terbinafine).
      • Cell wall level: Echinocandins
      • Mitotic spindle: Griseofulvin
    • Various other specific antifungal therapy options are also available

    Complications

    • Severe ringworm infections can cause scarring alopecia on the scalp.
    • Fungal infections may be problematic (epidemics) in schools, and their presentation can be masked by topical steroid use.

    Differential Diagnoses

    • Conditions that mimic fungal infections should be considered such as skin conditions such as seborrheic eczema, psoriasis, carbuncles, abscesses, eczema, and candidiasis, pityriasis rosea, erythrasma.

    Treatment Summary

    • Antifungal medications, both topical and systemic, are used to treat different types of fungal infections.

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    Fungal Skin Infection - PDF

    Description

    Test your knowledge on fungal infections, particularly those caused by dermatophytes. This quiz covers various aspects including characteristics, transmission, and treatment of these infections. Delve into clinical manifestations and management strategies to assess your understanding of this important topic in mycology.

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