Fungal Meningitis Treatment Quiz
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Questions and Answers

Which class of antifungal agents primarily inhibits an enzyme necessary to generate ergosterol?

  • Echinocandins
  • Polyenes
  • Azoles (correct)
  • Allylamines
  • Which antifungal agent is specifically noted for being effective against dermatophytes and is typically administered orally?

  • Fluconazole
  • Terbinafine (correct)
  • Clotrimazole
  • Itraconazole
  • Among the azoles, which agent is the preferred treatment for yeast infections but has limited activity against molds?

  • Terbinafine
  • Fluconazole (correct)
  • Clotrimazole
  • Itraconazole
  • Which class of antifungal agents disrupts the fungal cell wall synthesis by inhibiting glucan synthesis?

    <p>Echinocandins</p> Signup and view all the answers

    Flucytosine exerts its antifungal effect by inhibiting which process in fungi?

    <p>DNA and protein synthesis</p> Signup and view all the answers

    Which antifungal agent penetrates widely into most body tissues, based on the provided information?

    <p>Flucytosine</p> Signup and view all the answers

    What is a key reason for the increased incidence of fungal infections according to the text?

    <p>Medicines that have prolonged life expectancy</p> Signup and view all the answers

    Why are fungal infections generally more difficult to treat compared to bacterial infections?

    <p>Fungi are slow-growing and often occur in poorly penetrated tissues</p> Signup and view all the answers

    Which antifungal agent binds to ergosterol within the fungal cell membrane, leading to pore formation and disruption of the fungal membrane?

    <p>Polyenes</p> Signup and view all the answers

    What is a common toxic effect associated with the primary polyene antifungal agent, amphotericin B (AMB)?

    <p>Renal impairment</p> Signup and view all the answers

    Which class of antifungal agents is known to be toxic for patients while being the only agent that can kill most fungi?

    <p>Polyenes</p> Signup and view all the answers

    Why is resistance to amphotericin B (AMB) a concern according to the text?

    <p>It has been documented with a number of organisms</p> Signup and view all the answers

    What is a common mechanism of resistance to antifungals mentioned in the text?

    <p>Increase of drug efflux</p> Signup and view all the answers

    Which type of infection is flucytosine very effective in treating according to the text?

    <p>Candida spp. infections</p> Signup and view all the answers

    What is one of the uses of flucytosine as mentioned in the text?

    <p>Prophylactic treatment for end-stage AIDS patients</p> Signup and view all the answers

    In antifungal susceptibility testing, which method involves using different disk diffusion antifungal disks?

    <p>Disk diffusion</p> Signup and view all the answers

    What is mentioned as a side effect of the treatment for fungal meningitis in the text?

    <p>Wide range of side effects</p> Signup and view all the answers

    Which pathway alteration is mentioned as a mechanism of resistance to antifungals in the text?

    <p>Ergosterol biosynthesis pathway alteration</p> Signup and view all the answers

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