Fungal Infections Types and Examples
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Questions and Answers

What type of change in the pharmacological response is characterized by a change in the duration of the response?

  • Quantitative change
  • Qualitative change
  • Duration change (correct)
  • None of the above
  • Which factor can lead to prescription errors due to interactions, especially in drugs with a low therapeutic index?

  • Self-medication with OTC drugs
  • Multiple prescriptions (correct)
  • Genetics
  • Lack of patient compliance
  • How can an individual's genetic makeup affect their response to a drug?

  • By affecting pharmacokinetics and pharmacodynamics (correct)
  • By changing the pH of the gastrointestinal tract
  • By causing therapy failure
  • By altering drug binding interactions
  • Which type of drug interactions are related to co-administration with drugs of abuse?

    <p>Drug-Drug interactions</p> Signup and view all the answers

    What is a common cause of therapy failure related to drug interactions?

    <p>Genetic variabilities</p> Signup and view all the answers

    How can mutations impact drug interactions?

    <p>By changing the magnitude of the response</p> Signup and view all the answers

    What is the main sterol in the fungal cell membrane that polyenes bind to?

    <p>Ergosterol</p> Signup and view all the answers

    What characteristic of Fluconazole makes it different from ketoconazole in terms of absorption?

    <p>Not affected by antacid coadministration</p> Signup and view all the answers

    Which antifungal agent is used for local infections such as skin and vaginal candidiasis due to its toxicity?

    <p>Nystatin</p> Signup and view all the answers

    Which antifungal agent disrupts nucleic acid synthesis by being activated to 5-Flurouracil?

    <p>Flucytosine</p> Signup and view all the answers

    What is the mechanism of action of azoles in inhibiting fungal growth?

    <p>Inhibiting 14-α-demethylase</p> Signup and view all the answers

    How does Griseofulvin exert its antifungal effect?

    <p>Disrupts mitosis by binding to microtubules</p> Signup and view all the answers

    Which antifungal agent is a CYP450 inducer, potentially causing therapy failure of other drugs?

    <p>Griseofulvin</p> Signup and view all the answers

    Which antifungal agent is used intrathecally to reach cerebrospinal fluid for meningitis treatment?

    <p>Amphotericin-B</p> Signup and view all the answers

    What formulation of Amphotericin-B is used to reduce nephrotoxicity by increasing tolerance?

    <p>Liposomal</p> Signup and view all the answers

    What is the main indication for the use of Flucytosine in combination therapy?

    <p>Systemic candidiasis</p> Signup and view all the answers

    Which antifungal agent inhibits ergosterol synthesis at the level of squalene epoxidase?

    <p>Terbinafine</p> Signup and view all the answers

    Which fungal infection causes wart-like lesions on the skin and subcutaneous tissue?

    <p>Chromoblastomycosis</p> Signup and view all the answers

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