Podcast
Questions and Answers
What type of change in the pharmacological response is characterized by a change in the duration of the response?
What type of change in the pharmacological response is characterized by a change in the duration of the response?
Which factor can lead to prescription errors due to interactions, especially in drugs with a low therapeutic index?
Which factor can lead to prescription errors due to interactions, especially in drugs with a low therapeutic index?
How can an individual's genetic makeup affect their response to a drug?
How can an individual's genetic makeup affect their response to a drug?
Which type of drug interactions are related to co-administration with drugs of abuse?
Which type of drug interactions are related to co-administration with drugs of abuse?
Signup and view all the answers
What is a common cause of therapy failure related to drug interactions?
What is a common cause of therapy failure related to drug interactions?
Signup and view all the answers
How can mutations impact drug interactions?
How can mutations impact drug interactions?
Signup and view all the answers
What is the main sterol in the fungal cell membrane that polyenes bind to?
What is the main sterol in the fungal cell membrane that polyenes bind to?
Signup and view all the answers
What characteristic of Fluconazole makes it different from ketoconazole in terms of absorption?
What characteristic of Fluconazole makes it different from ketoconazole in terms of absorption?
Signup and view all the answers
Which antifungal agent is used for local infections such as skin and vaginal candidiasis due to its toxicity?
Which antifungal agent is used for local infections such as skin and vaginal candidiasis due to its toxicity?
Signup and view all the answers
Which antifungal agent disrupts nucleic acid synthesis by being activated to 5-Flurouracil?
Which antifungal agent disrupts nucleic acid synthesis by being activated to 5-Flurouracil?
Signup and view all the answers
What is the mechanism of action of azoles in inhibiting fungal growth?
What is the mechanism of action of azoles in inhibiting fungal growth?
Signup and view all the answers
How does Griseofulvin exert its antifungal effect?
How does Griseofulvin exert its antifungal effect?
Signup and view all the answers
Which antifungal agent is a CYP450 inducer, potentially causing therapy failure of other drugs?
Which antifungal agent is a CYP450 inducer, potentially causing therapy failure of other drugs?
Signup and view all the answers
Which antifungal agent is used intrathecally to reach cerebrospinal fluid for meningitis treatment?
Which antifungal agent is used intrathecally to reach cerebrospinal fluid for meningitis treatment?
Signup and view all the answers
What formulation of Amphotericin-B is used to reduce nephrotoxicity by increasing tolerance?
What formulation of Amphotericin-B is used to reduce nephrotoxicity by increasing tolerance?
Signup and view all the answers
What is the main indication for the use of Flucytosine in combination therapy?
What is the main indication for the use of Flucytosine in combination therapy?
Signup and view all the answers
Which antifungal agent inhibits ergosterol synthesis at the level of squalene epoxidase?
Which antifungal agent inhibits ergosterol synthesis at the level of squalene epoxidase?
Signup and view all the answers
Which fungal infection causes wart-like lesions on the skin and subcutaneous tissue?
Which fungal infection causes wart-like lesions on the skin and subcutaneous tissue?
Signup and view all the answers