Fungal Infections Types and Examples

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What type of change in the pharmacological response is characterized by a change in the duration of the response?

Duration change

Which factor can lead to prescription errors due to interactions, especially in drugs with a low therapeutic index?

Multiple prescriptions

How can an individual's genetic makeup affect their response to a drug?

By affecting pharmacokinetics and pharmacodynamics

Which type of drug interactions are related to co-administration with drugs of abuse?

<p>Drug-Drug interactions</p> Signup and view all the answers

What is a common cause of therapy failure related to drug interactions?

<p>Genetic variabilities</p> Signup and view all the answers

How can mutations impact drug interactions?

<p>By changing the magnitude of the response</p> Signup and view all the answers

What is the main sterol in the fungal cell membrane that polyenes bind to?

<p>Ergosterol</p> Signup and view all the answers

What characteristic of Fluconazole makes it different from ketoconazole in terms of absorption?

<p>Not affected by antacid coadministration</p> Signup and view all the answers

Which antifungal agent is used for local infections such as skin and vaginal candidiasis due to its toxicity?

<p>Nystatin</p> Signup and view all the answers

Which antifungal agent disrupts nucleic acid synthesis by being activated to 5-Flurouracil?

<p>Flucytosine</p> Signup and view all the answers

What is the mechanism of action of azoles in inhibiting fungal growth?

<p>Inhibiting 14-α-demethylase</p> Signup and view all the answers

How does Griseofulvin exert its antifungal effect?

<p>Disrupts mitosis by binding to microtubules</p> Signup and view all the answers

Which antifungal agent is a CYP450 inducer, potentially causing therapy failure of other drugs?

<p>Griseofulvin</p> Signup and view all the answers

Which antifungal agent is used intrathecally to reach cerebrospinal fluid for meningitis treatment?

<p>Amphotericin-B</p> Signup and view all the answers

What formulation of Amphotericin-B is used to reduce nephrotoxicity by increasing tolerance?

<p>Liposomal</p> Signup and view all the answers

What is the main indication for the use of Flucytosine in combination therapy?

<p>Systemic candidiasis</p> Signup and view all the answers

Which antifungal agent inhibits ergosterol synthesis at the level of squalene epoxidase?

<p>Terbinafine</p> Signup and view all the answers

Which fungal infection causes wart-like lesions on the skin and subcutaneous tissue?

<p>Chromoblastomycosis</p> Signup and view all the answers

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