Podcast
Questions and Answers
What happens to the number of motoneurons if a limb bud is removed from a chick embryo?
What happens to the number of motoneurons if a limb bud is removed from a chick embryo?
- The number of motoneurons varies randomly.
- The number of motoneurons remains the same.
- The number of motoneurons increases.
- The number of motoneurons decreases. (correct)
What effect does increasing the size of a limb target by transplanting an extra limb bud have on motoneuron death?
What effect does increasing the size of a limb target by transplanting an extra limb bud have on motoneuron death?
- Causes random changes in motoneuron death.
- Has no impact on motoneuron death.
- Reduces motoneuron death. (correct)
- Increases motoneuron death.
What is the main role of trophic factors in relation to neurons?
What is the main role of trophic factors in relation to neurons?
- To induce neuronal migration.
- To support neuron survival. (correct)
- To stimulate axon growth.
- To provoke apoptosis.
What is the function of Nerve Growth Factor (NGF) according to the text?
What is the function of Nerve Growth Factor (NGF) according to the text?
What happens if NGF function is disrupted in vivo according to the text?
What happens if NGF function is disrupted in vivo according to the text?
Which statement best describes the role of neurotrophins?
Which statement best describes the role of neurotrophins?
What effect does adding curare (a drug blocking muscle contractions) have on motoneurons?
What effect does adding curare (a drug blocking muscle contractions) have on motoneurons?
Which molecule is responsible for the trophic activity of Nerve Growth Factor (NGF)?
Which molecule is responsible for the trophic activity of Nerve Growth Factor (NGF)?
Which neurotrophin binds all the TRKs?
Which neurotrophin binds all the TRKs?
What is the function of p75 in response to neurotrophin binding?
What is the function of p75 in response to neurotrophin binding?
How are all trks activated?
How are all trks activated?
Which adaptor protein binds to phosphorylated Shc after trkA activation?
Which adaptor protein binds to phosphorylated Shc after trkA activation?
What is the role of Akt in promoting cell survival?
What is the role of Akt in promoting cell survival?
Which protein inhibits apoptosis by promoting the exchange of GDP for GTP bound to Ras?
Which protein inhibits apoptosis by promoting the exchange of GDP for GTP bound to Ras?
What is the main outcome of injecting DNA for activated MEK into PC12 cells?
What is the main outcome of injecting DNA for activated MEK into PC12 cells?
What happens when neurotrophins regulate the ras/raf/mek/erk kinase cascade?
What happens when neurotrophins regulate the ras/raf/mek/erk kinase cascade?
What is the primary function of downstream effector proteins in neurotrophin signaling pathways?
What is the primary function of downstream effector proteins in neurotrophin signaling pathways?
What characterizes the binding affinity between neurotrophins and p75 receptor?
What characterizes the binding affinity between neurotrophins and p75 receptor?
What are the 4 classic morphological features characteristic of apoptosis?
What are the 4 classic morphological features characteristic of apoptosis?
What is the purpose of apoptosis during development according to the text?
What is the purpose of apoptosis during development according to the text?
Which process involves an active biochemical program leading to cell death often referred to as 'cell suicide'?
Which process involves an active biochemical program leading to cell death often referred to as 'cell suicide'?
How was apoptosis first imaged according to the text?
How was apoptosis first imaged according to the text?
Which term describes cell death resulting from traumatic injury involving rapid cell lysis?
Which term describes cell death resulting from traumatic injury involving rapid cell lysis?
What was the significance of the first experiments performed to prove apoptosis as an active biochemical process?
What was the significance of the first experiments performed to prove apoptosis as an active biochemical process?
What process involves balancing the number of neurons with the amount of target that needs to be innervated in the nervous system?
What process involves balancing the number of neurons with the amount of target that needs to be innervated in the nervous system?
How does apoptosis contribute to sculpting the final tissue structure during development?
How does apoptosis contribute to sculpting the final tissue structure during development?
In apoptosis, what happens to the cell during the process?
In apoptosis, what happens to the cell during the process?
Why did the first experiments using mRNA/protein synthesis inhibitors help prove apoptosis as an active biochemical process?
Why did the first experiments using mRNA/protein synthesis inhibitors help prove apoptosis as an active biochemical process?
Which family member inhibits ced-4 to prevent caspase cleavage?
Which family member inhibits ced-4 to prevent caspase cleavage?
What is considered the 'point of no return' in apoptotic cell death?
What is considered the 'point of no return' in apoptotic cell death?
Where does neurotrophin signaling occur due to retrograde transport of a vesicle carrying the trk receptor?
Where does neurotrophin signaling occur due to retrograde transport of a vesicle carrying the trk receptor?
Which hormone readily crosses the blood-brain barrier and regulates gene expression by translocating to the nucleus?
Which hormone readily crosses the blood-brain barrier and regulates gene expression by translocating to the nucleus?
