Freeze-Drying of Proteins

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Questions and Answers

What is the primary goal of using closed loop systems in protein delivery?

  • To calculate the required input rate for the delivery system
  • To measure the plasma level of the protein
  • To stabilize a certain body function (correct)
  • To administer the drug at a constant rate over time

What is the primary mechanism of the competitive desorption approach in self-regulating systems?

  • Competition between glycosylated insulin and glucose for binding sites (correct)
  • Enzyme-substrate reactions
  • Allosteric modification of insulin structure
  • pH drop induced by glucose conversion

What is the ultimate goal of self-regulating systems in insulin release?

  • To maintain a constant blood glucose level
  • To stabilize blood glucose levels in diabetics (correct)
  • To administer insulin at a constant rate over time
  • To regulate insulin release based on local glucose concentrations

What is the role of glucose oxidase in enzyme-substrate reactions?

<p>To convert glucose to gluconic acid (D)</p> Signup and view all the answers

What is the function of the algorithm in closed loop systems?

<p>To calculate the required input rate for the delivery system (B)</p> Signup and view all the answers

What is the mechanism of insulin release from an implanted reservoir in self-regulating systems?

<p>pH drop induced by glucose conversion (D)</p> Signup and view all the answers

What is the primary advantage of self-regulating systems in insulin delivery?

<p>Regulation of insulin release based on local glucose concentrations (B)</p> Signup and view all the answers

What is the role of concanavalin (Con A) in the competitive desorption approach?

<p>To bind to glycosylated insulin (B)</p> Signup and view all the answers

What is the primary component of the self-regulating insulin delivery system?

<p>Imobilized Con A beads (D)</p> Signup and view all the answers

What is the function of the pump system in closed loop systems?

<p>To administer the drug at the required rate over time (B)</p> Signup and view all the answers

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