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Freeze-Drying of Proteins

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Questions and Answers

What is the primary goal of using closed loop systems in protein delivery?

To calculate the required input rate for the delivery system

To measure the plasma level of the protein

To stabilize a certain body function (correct)

To administer the drug at a constant rate over time

What is the primary mechanism of the competitive desorption approach in self-regulating systems?

Competition between glycosylated insulin and glucose for binding sites (correct)

Enzyme-substrate reactions

Allosteric modification of insulin structure

pH drop induced by glucose conversion

What is the ultimate goal of self-regulating systems in insulin release?

To maintain a constant blood glucose level

To stabilize blood glucose levels in diabetics (correct)

To administer insulin at a constant rate over time

To regulate insulin release based on local glucose concentrations

What is the role of glucose oxidase in enzyme-substrate reactions?

To convert glucose to gluconic acid Signup and view all the answers

What is the function of the algorithm in closed loop systems?

To calculate the required input rate for the delivery system Signup and view all the answers

What is the mechanism of insulin release from an implanted reservoir in self-regulating systems?

pH drop induced by glucose conversion Signup and view all the answers

What is the primary advantage of self-regulating systems in insulin delivery?

Regulation of insulin release based on local glucose concentrations Signup and view all the answers

What is the role of concanavalin (Con A) in the competitive desorption approach?

To bind to glycosylated insulin Signup and view all the answers

What is the primary component of the self-regulating insulin delivery system?

Imobilized Con A beads Signup and view all the answers

What is the function of the pump system in closed loop systems?

To administer the drug at the required rate over time Signup and view all the answers