16 Questions
What is the primary role of hemopexin in the handling of free heme?
To bind free heme and transport it to the liver
What is the main purpose of haptoglobin in the handling of free hemoglobin?
To metabolize the hemoglobin-haptoglobin complex in the liver and spleen
What is the purpose of the enterohepatic circulation in bilirubin metabolism?
To recycle bilirubin back to the liver after it has been excreted in the bile
What is the purpose of the conjugation step in hepatic bilirubin transport?
To convert bilirubin into a more water-soluble form for biliary excretion
What is the purpose of methemalbumin in the handling of free heme?
To form a complex of oxidized heme and albumin
What type of bilirubin does total bilirubin measure?
Indirect bilirubin
Which enzyme is responsible for the conjugation of bilirubin?
Uridine diphosphate glucuronyl transferase
What occurs nonenzymatically to convert conjugated bilirubin back to unconjugated bilirubin?
Hydrolysis in the duodenum and jejunum
What reaches adult levels by 3-5 days regarding bilirubin transportation?
Ligandins
In which organ is β glucuronidase found in high concentration?
Duodenum
What is the main purpose of hemopexin in the handling of free heme?
Bind free heme for uptake by the liver
What happens to conjugated bilirubin in bilirubin metabolism?
Converted to stercobilinogen by bacteria
How is unconjugated bilirubin transported in plasma?
Transported by albumin to the liver
What is the function of methemalbumin in the handling of free heme?
Complex oxidized heme with albumin
Where does the majority of bilirubin come from in normal adults?
Red blood cell degradation
What is the fate of stercobilin produced from bilirubin metabolism?
Re-absorption through enterohepatic circulation
Explore how the body handles free (intravascular) hemoglobin to scavenge iron, prevent iron losses, and complex toxic free heme. Learn about the roles of haptoglobin, hemopexin, and methemalbumin in metabolizing hemoglobin and preventing iron loss in urine.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
