Free Hemoglobin Metabolism

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Questions and Answers

What is the primary role of hemopexin in the handling of free heme?

  • To prevent the loss of iron in urine
  • To metabolize the heme-hemopexin complex in the liver
  • To bind free heme and transport it to the liver (correct)
  • To store the iron from the heme-hemopexin complex bound to ferritin

What is the main purpose of haptoglobin in the handling of free hemoglobin?

  • To prevent major iron losses
  • To metabolize the hemoglobin-haptoglobin complex in the liver and spleen (correct)
  • To complex free heme
  • To scavenge iron

What is the purpose of the enterohepatic circulation in bilirubin metabolism?

  • To conjugate bilirubin in the liver
  • To recycle bilirubin back to the liver after it has been excreted in the bile (correct)
  • To transport bilirubin in the plasma
  • To facilitate the hepatic uptake of bilirubin

What is the purpose of the conjugation step in hepatic bilirubin transport?

<p>To convert bilirubin into a more water-soluble form for biliary excretion (B)</p> Signup and view all the answers

What is the purpose of methemalbumin in the handling of free heme?

<p>To form a complex of oxidized heme and albumin (D)</p> Signup and view all the answers

What type of bilirubin does total bilirubin measure?

<p>Indirect bilirubin (B)</p> Signup and view all the answers

Which enzyme is responsible for the conjugation of bilirubin?

<p>Uridine diphosphate glucuronyl transferase (B)</p> Signup and view all the answers

What occurs nonenzymatically to convert conjugated bilirubin back to unconjugated bilirubin?

<p>Hydrolysis in the duodenum and jejunum (C)</p> Signup and view all the answers

What reaches adult levels by 3-5 days regarding bilirubin transportation?

<p>Ligandins (D)</p> Signup and view all the answers

In which organ is β glucuronidase found in high concentration?

<p>Duodenum (A)</p> Signup and view all the answers

What is the main purpose of hemopexin in the handling of free heme?

<p>Bind free heme for uptake by the liver (C)</p> Signup and view all the answers

What happens to conjugated bilirubin in bilirubin metabolism?

<p>Converted to stercobilinogen by bacteria (C)</p> Signup and view all the answers

How is unconjugated bilirubin transported in plasma?

<p>Transported by albumin to the liver (C)</p> Signup and view all the answers

What is the function of methemalbumin in the handling of free heme?

<p>Complex oxidized heme with albumin (C)</p> Signup and view all the answers

Where does the majority of bilirubin come from in normal adults?

<p>Red blood cell degradation (C)</p> Signup and view all the answers

What is the fate of stercobilin produced from bilirubin metabolism?

<p>Re-absorption through enterohepatic circulation (C)</p> Signup and view all the answers

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