Handling of Free (Intravascular) Hemoglobin

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Questions and Answers

What is the primary measurement used to determine the level of bilirubin in the body?

  • Direct bilirubin measurement
  • Total bilirubin measurement (correct)
  • Conjugated bilirubin measurement
  • Indirect bilirubin measurement

What is the role of ligandins in bilirubin physiology?

  • Ligandins are responsible for the transport of bilirubin from the plasma membrane to the endoplasmic reticulum. (correct)
  • Ligandins are responsible for the excretion of bilirubin into the bile canaliculi.
  • Ligandins are involved in the enterohepatic circulation of bilirubin.
  • Ligandins are involved in the conjugation of bilirubin with glucuronides.

What enzyme is responsible for the conjugation of bilirubin with glucuronides?

  • Beta-glucuronidase
  • Bilirubin ligandins
  • Uridine diphosphate glucuronyl transferase (UDPGT) (correct)
  • Plasma membrane transporters

What is the primary cause of the instability and hydrolysis of conjugated bilirubin in the duodenum and jejunum?

<p>The presence of beta-glucuronidase (D)</p> Signup and view all the answers

What is the primary reason for the increased levels of unconjugated bilirubin in newborn infants?

<p>Decreased conjugation of bilirubin due to immature liver function (C)</p> Signup and view all the answers

Which of the following is NOT a primary purpose for the handling of free (intravascular) hemoglobin?

<p>Facilitating the transportation of oxygen (A)</p> Signup and view all the answers

Which of the following statements about haptoglobin is incorrect?

<p>It is responsible for binding free heme in the bloodstream. (A)</p> Signup and view all the answers

What is the primary function of hemopexin?

<p>Binding free heme and facilitating its uptake by the liver (C)</p> Signup and view all the answers

Which of the following statements about bilirubin metabolism is incorrect?

<p>Conjugated bilirubin is hydrophilic and is excreted directly into the bile. (A)</p> Signup and view all the answers

What is the fate of stercobilinogen (urobilinogen) produced by gut bacteria from bilirubin?

<p>It is oxidized to stercobilin and excreted in feces. (A)</p> Signup and view all the answers

How is the determination of bilirubin levels in serum samples performed?

<p>Conjugated bilirubin reacts directly with reagents, while free bilirubin requires an additional step. (D)</p> Signup and view all the answers

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