Foundations for Practice in Respiratory Lectures
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Questions and Answers

What is the approximate value of PvO2 in mmHg?

  • 40 mmHg (correct)
  • 100 mmHg
  • 95 mmHg
  • 150 mmHg
  • What does the arteriovenous difference indicate?

  • Amount of oxygen extracted from each litre of blood (correct)
  • Rate of blood flow per minute
  • Amount of carbon dioxide transported in blood
  • Capacity of the lungs to ventilate
  • Which of these values represents the partial pressure of oxygen (PaO2) in mmHg?

  • 40 mmHg
  • 95 mmHg (correct)
  • 150 mmHg
  • 100 mmHg
  • How does oxygen transport occur in blood?

    <p>By binding to hemoglobin and dissolving in plasma (B)</p> Signup and view all the answers

    What is the PACO2 value in mmHg?

    <p>40 mmHg (B)</p> Signup and view all the answers

    Which of the following pH values indicates a potential acidosis condition?

    <p>7.2 (C)</p> Signup and view all the answers

    What can be inferred if the PaCO2 is significantly higher than the normal range?

    <p>There is a potential respiratory depression. (D)</p> Signup and view all the answers

    Which condition is most likely indicated by a marked increase in HCO3─ levels?

    <p>Metabolic alkalosis (A)</p> Signup and view all the answers

    What is the likely volume of oxygen transfer from alveoli to pulmonary capillaries at rest?

    <p>250 mL/min (B)</p> Signup and view all the answers

    How much oxygen does the lungs add to each liter of blood during gas exchange?

    <p>50 mL O2/L (A)</p> Signup and view all the answers

    Which of the following is a primary characteristic symptom of bronchiectasis?

    <p>Large amounts of muco-purulent sputum (B)</p> Signup and view all the answers

    What mechanical issue is commonly seen in bronchiectasis due to muscle and elastic tissue weakness?

    <p>Obstructive ventilatory defects (B)</p> Signup and view all the answers

    Which conditions are associated with an increased prevalence of bronchiectasis?

    <p>Gamma globulin deficiency and cystic fibrosis (D)</p> Signup and view all the answers

    What does peak expiratory flow primarily indicate during forced expiration?

    <p>It indicates an early maximum flow rate. (C)</p> Signup and view all the answers

    In the context of restrictive ventilatory defects, what happens to the FEV1 and FVC values?

    <p>Both FEV1 and FVC are reduced in parallel. (C)</p> Signup and view all the answers

    What effect does inspiratory flow impairment suggest?

    <p>Extra-thoracic obstruction. (C)</p> Signup and view all the answers

    Why is the FEV1/FVC ratio often increased in restrictive ventilatory defects?

    <p>There is increased elastic recoil of the lungs assisting expiration. (C)</p> Signup and view all the answers

    What characteristic defines airflow at low lung volumes in the context of lung function tests?

    <p>It is less effort-dependent and reflects small airway condition. (C)</p> Signup and view all the answers

    What happens during the expiratory phase in restrictive ventilatory defects?

    <p>There is fast flow due to sufficient lung elasticity. (D)</p> Signup and view all the answers

    What output is typically plotted in the FEV1/FVC ratio and what does it signify?

    <p>The proportion of air expelled in the first second indicating obstruction. (C)</p> Signup and view all the answers

    What is the most significant factor affecting laminar flow resistance in airways?

    <p>Radius of the airway (A)</p> Signup and view all the answers

    Which statement about pressures during a normal respiratory cycle is true?

    <p>Pressure fluctuations assist in the initiation of the breathing cycle. (C)</p> Signup and view all the answers

    Which of the following correctly describes turbulent flow in airways?

    <p>Flow is characterized by swirls and eddies (D)</p> Signup and view all the answers

    What clinical signs indicate increased airway resistance during respiration?

    <p>Wheezing or rhonchi (B)</p> Signup and view all the answers

    In the context of airway resistance, which law is the Poiseuille equation simplistically replaced by?

    <p>Ohm's law (B)</p> Signup and view all the answers

    Which statement about laminar flow is true?

    <p>The central lamina flows at the fastest velocity. (C)</p> Signup and view all the answers

    What is the primary cause of turbulence in airflow?

    <p>Increased mean velocity of airflow (B)</p> Signup and view all the answers

    Which parameter is most relevant for predicting airflow resistance in respiratory pathology?

    <p>Radius of the airway (A)</p> Signup and view all the answers

    Which formula correctly relates blood flow resistance to the physical properties of blood vessels?

    <p>F = (P1-P2) * πr⁴ / 8ηL (C)</p> Signup and view all the answers

    Imagine a person takes a deep breath in, then breathes out as much as possible. What would the remaining volume of air in their lungs be classified as?

    <p>Residual Volume (B)</p> Signup and view all the answers

    What is the difference between 'Tidal Volume' and 'Minute Volume'?

    <p>Tidal volume is the amount of air breathed in and out in a single breath, while minute volume is the total amount of air breathed in one minute. (A)</p> Signup and view all the answers

    Based on the text, what is the primary factor that influences the volume of air that can be forcefully exhaled after a normal expiration?

    <p>The volume of air inhaled during the previous breath. (C)</p> Signup and view all the answers

    A patient's breathing rate is measured to be 12 breaths per minute. Their Tidal Volume is measured to be 500 ml. Using this information, calculate their Minute Volume.

    <p>6,000 ml (D)</p> Signup and view all the answers

    Which of the following scenarios would lead to a higher Minute Volume?

    <p>After intense exercise, when breathing is rapid and deep. (D)</p> Signup and view all the answers

    Which of the following is NOT directly considered when determining the Functional Residual Capacity?

    <p>Inspiratory Reserve Volume (B)</p> Signup and view all the answers

    What is the primary purpose of the Residual Volume?

    <p>To prevent collapse of the alveoli during exhalation. (C)</p> Signup and view all the answers

    Imagine a person with a significantly decreased lung capacity due to a health condition. Which of the following volumes would be MOST affected?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the primary role of Type 1 pneumocytes in the alveolar structure?

    <p>Facilitate gas diffusion thanks to their thinness (A)</p> Signup and view all the answers

    Which component significantly contributes to lung compliance along with surface tension?

    <p>Elastin fibres (A)</p> Signup and view all the answers

    What substance do Type 2 pneumocytes secrete, and what is its function?

    <p>Surfactant; to reduce surface tension (D)</p> Signup and view all the answers

    What distinguishes Type 1 pneumocytes from Type 2 pneumocytes?

    <p>Type 2 pneumocytes have more cytoplasm (C)</p> Signup and view all the answers

    What is the primary composition of the wall between blood in the pulmonary capillary and the air?

    <p>Epithelial cells, endothelial cells, and interstitium (B)</p> Signup and view all the answers

    How does surfactant influence the alveoli?

    <p>It prevents the collapse of alveoli during exhalation (D)</p> Signup and view all the answers

    Which of the following best describes the interstitium in the context of the pulmonary capillary wall?

    <p>A connective tissue layer (D)</p> Signup and view all the answers

    What is the total surface area for gas exchange provided by the alveoli?

    <p>70-100 m2 (B)</p> Signup and view all the answers

    Flashcards

    Partial Pressure of Oxygen (PAO2)

    The pressure of oxygen in the alveoli, determining O2 availability for gas exchange.

    Partial Pressure of Carbon Dioxide (PACO2)

    The pressure of carbon dioxide in the alveoli, influencing respiratory drive.

    Oxygen Content in Blood (CaO2)

    Total amount of oxygen carried in a liter of arterial blood, measured in mL/L.

    Oxygen Extraction (Arteriovenous Difference)

    Difference in oxygen content between arterial and venous blood indicating how much is used by tissues.

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    Oxygen Transport Mechanism

    The flow and transfer of oxygen from lungs to tissues through blood circulation.

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    Tidal Volume

    The volume of air inhaled or exhaled during normal breathing.

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    Minute Volume

    The total volume of air breathed in one minute, calculated as tidal volume times respiratory frequency.

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    Inspiratory Reserve Volume

    The additional volume of air that can be inhaled after a normal inspiration.

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    Expiratory Reserve Volume

    The additional volume of air that can be exhaled after a normal expiration.

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    Residual Volume

    The volume of air left in the lungs after maximal expiration.

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    Vital Capacity

    The maximum amount of air that can be exhaled after a maximum inhalation, consisting of tidal volume, inspiratory reserve volume, and expiratory reserve volume.

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    Total Lung Capacity

    The total volume of air in the lungs after the largest inhalation, includes all lung volumes.

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    Functional Residual Capacity

    The volume of air remaining in the lungs after normal expiration, includes expiratory reserve volume and residual volume.

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    Type 1 pneumocytes

    Thin squamous epithelial cells in alveoli important for gas diffusion.

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    Type 2 pneumocytes

    Thicker epithelial cells that produce surfactant to reduce surface tension in alveoli.

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    Surfactant

    A substance that reduces surface tension in the alveoli, aiding lung compliance.

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    Alveolar wall composition

    Composed of Type 1 and Type 2 pneumocytes, endothelial cells, and interstitium.

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    Lung compliance

    The ability of lung tissue to stretch and expand during breathing.

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    Elastic recoil

    The ability of lung tissue to return to its original shape after stretching.

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    Surface tension

    A force at the air-water interface in the alveoli that can affect lung expansion.

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    Elastin fibres

    Proteins in lung tissue that contribute to elastic recoil and lung compliance.

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    Laminar Flow

    A type of fluid flow where layers move parallel and smooth.

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    Turbulent Flow

    A type of fluid flow characterized by chaotic changes in pressure and flow velocity.

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    Poiseuille's Law

    A formula describing laminar flow dependent on pressure, radius, and viscosity.

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    Pressure Gradient (P1-P2)

    The difference in pressure between two points that drives fluid movement.

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    Airway Resistance (AWR)

    The resistance to airflow in the airways, related to size and viscosity.

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    Clinical Significance of Turbulent Flow

    Indicates narrowed airways due to increased flow velocity required for same volume.

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    Wheeze and Rhonchi

    Sounds resulting from turbulent airflow in narrowed airways; indicate resistance.

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    Viscosity in Flow

    The measure of a fluid's resistance to flow due to internal friction between layers.

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    Peak Expiratory Flow

    The maximum rate of air flow during forced expiration, occurring early in the expiration phase.

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    FEV1

    Forced Expiratory Volume in one second; the amount of air a person can exhale in the first second of a forced breath.

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    FVC

    Forced Vital Capacity; the total amount of air exhaled during a forced breath after maximum inhalation.

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    FEV1/FVC Ratio

    A percentage calculation that compares FEV1 to FVC, indicating airflow limitation.

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    Restrictive Ventilatory Defect

    A condition where both FEV1 and FVC are reduced, but the FEV1/FVC ratio remains normal or increases.

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    Obstructive Ventilatory Defect

    Condition where FEV1 is reduced more than FVC, leading to a decreased FEV1/FVC ratio.

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    Intra-thoracic Obstruction

    Blockage occurring inside the thoracic cavity affecting expiration.

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    Extra-thoracic Obstruction

    Blockage occurring outside the thoracic cavity, impacting inspiration.

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    Acid-base disturbance

    An abnormality in body pH, indicated by levels of pH, PaCO2, and HCO3-.

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    Normal pH range

    The normal pH for blood is approximately 7.35 to 7.45.

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    PaCO2 levels

    Partial pressure of carbon dioxide; normal levels range from 4.7 to 6.0 kPa.

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    HCO3- levels

    Bicarbonate ion concentration; normal levels are between 22 to 26 mmol/L.

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    Oxygen transfer rate

    The volume of oxygen transferred from alveoli to capillaries at rest is about 250 mL/min.

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    Mixed venous blood oxygen content

    Contains about 150 mL O2/L; this is the blood returning to the lungs.

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    Bronchiectasis

    A condition of dilated bronchi leading to chronic infection and excess mucus.

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    Ciliary dyskinesia

    A genetic disorder leading to impaired ciliary movement, increasing infection risk.

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    Study Notes

    Foundations for Practice

    • This guide is for use with other module components (lectures, practicals, tutorials, self-directed study) and particularly respiratory lectures
    • Students should read the guide before lectures to understand the course structure and focus areas
    • Lectures will expand on concepts using figures, graphs and data.

    Contents

    • The guide is divided into chapters, each covering the content of one lecture
    • Each chapter corresponds to a numbered lecture slide
    • Figures and slides, along with discussions, are used in conjunction with the guide

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    Description

    This guide serves as a companion to respiratory lectures, providing a structured overview of course content. Students are encouraged to review each chapter before lectures to enhance their understanding of key concepts illustrated through figures and data. The guide is essential for aligning practicals and tutorials with lecture content.

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