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Questions and Answers
What is the main bacterium targeted by Fosfomycin?
What is the main bacterium targeted by Fosfomycin?
Which side effect is commonly associated with Fosfomycin use?
Which side effect is commonly associated with Fosfomycin use?
How do protein synthesis inhibitors affect bacterial cells?
How do protein synthesis inhibitors affect bacterial cells?
Which subunit of the ribosome is targeted by protein synthesis inhibitors?
Which subunit of the ribosome is targeted by protein synthesis inhibitors?
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What type of activity do protein synthesis inhibitors exhibit depending on their binding nature?
What type of activity do protein synthesis inhibitors exhibit depending on their binding nature?
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Which class of antibiotics does Fosfomycin belong to based on its mechanism of action?
Which class of antibiotics does Fosfomycin belong to based on its mechanism of action?
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What is the mechanism of action of tetracyclines?
What is the mechanism of action of tetracyclines?
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Which of the following statements about Amikacin is true?
Which of the following statements about Amikacin is true?
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What makes Amikacin less susceptible to inactivating enzymes compared to other aminoglycosides?
What makes Amikacin less susceptible to inactivating enzymes compared to other aminoglycosides?
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Which of the following bacteria is Neomycin active against?
Which of the following bacteria is Neomycin active against?
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Which antibiotic is used to treat rosacea and prevent rhinophyma?
Which antibiotic is used to treat rosacea and prevent rhinophyma?
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Which bacterial strains is Clindamycin most effective against?
Which bacterial strains is Clindamycin most effective against?
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What is the main side effect associated with Clindamycin usage?
What is the main side effect associated with Clindamycin usage?
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How does Linezolid (Oxazolidinone) primarily affect bacterial protein synthesis?
How does Linezolid (Oxazolidinone) primarily affect bacterial protein synthesis?
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Which antibiotic is considered a second-generation oxazolidinone derivative that is more potent against MRSA and VRE?
Which antibiotic is considered a second-generation oxazolidinone derivative that is more potent against MRSA and VRE?
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What is a significant advantage of Fosfomycin when compared to other antibiotics?
What is a significant advantage of Fosfomycin when compared to other antibiotics?
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How does Fosfomycin primarily exert its antibiotic effect?
How does Fosfomycin primarily exert its antibiotic effect?
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Study Notes
Fosfomycin
- Rapid bactericidal effect and wide antibacterial spectrum including MRSA, VRE, and many Gram-negative bacteria
- Used to treat urinary tract infections and cystitis in women
- Side effects: Nephrotoxicity
Protein Synthesis Inhibitors
- Inhibit either the 30S or 50S ribosomal subunit, which differs from mammalian ones
- Can be bactericidal or bacteriostatic depending on the type of binding
- Classification: Macrolides, Clindamycin, Chloramphenicol, Aminoglycosides, Tetracyclins, and Linazolid
Aminoglycosides
- Bactericidal
- Examples: Amikacin, Gentamicin, Tobramycin, Streptomycin, Neomycin, and Kanamycin
- Uses: Broad-spectrum antibiotics, used in pseudomonal infections and in the treatment of tuberculosis
- Toxicity: Nephrotoxicity and Ototoxicity
Tetracyclines
- Bacteriostatic
- Act by reversibly binding to the 30S subunit of the ribosome at the A-site
- Examples: Oxytetracycline, Minocycline, Doxycycline
- Uses: Treat rosacea, prevent rhinophyma, and cover atypical bacteria, Gram-positive, and Gram-negative bacteria
- Spectrum: Includes Mycoplasma, Chlamydia, Rickettsiae, and Spirochetes, but not active against S. pyogenes and P. aeruginosa
Lincosamides
- Bacteriostatic
- Examples: Lincomycin, Clindamycin
- Uses: Effective against anaerobes, Gram-positive cocci, and MRSA
- Side effects: Pseudomembranous Colitis
Oxazolidinones
- Bacteriostatic
- Examples: Linezolid
- Uses: Active against Gram-positive bacteria, including VRE and MRSA, and can be used in people with liver disease or poor kidney function
- Side effects: Long-term usage (>2 weeks) may be associated with low platelet count
- Tedizolid is a second-generation oxazolidinone derivative that is 4-to-16-fold more potent against MRSA and VRE
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Description
Test your knowledge on Fosfomycin Streptomyces wedmorensis, an antibiotic with rapid bactericidal effect against MRSA, VRE, and Gram-negative bacteria. Explore its uses in treating skin infections and urinary tract infections, along with potential side effects.
