Fosfomycin Streptomyces wedmorensis (ATCC 21239) Quiz

What is the main bacterium targeted by Fosfomycin?

Which side effect is commonly associated with Fosfomycin use?

How do protein synthesis inhibitors affect bacterial cells?

Which subunit of the ribosome is targeted by protein synthesis inhibitors?

What type of activity do protein synthesis inhibitors exhibit depending on their binding nature?

Which class of antibiotics does Fosfomycin belong to based on its mechanism of action?

What is the mechanism of action of tetracyclines?

Which of the following statements about Amikacin is true?

What makes Amikacin less susceptible to inactivating enzymes compared to other aminoglycosides?

Which of the following bacteria is Neomycin active against?

Which antibiotic is used to treat rosacea and prevent rhinophyma?

Which bacterial strains is Clindamycin most effective against?

What is the main side effect associated with Clindamycin usage?

How does Linezolid (Oxazolidinone) primarily affect bacterial protein synthesis?

Which antibiotic is considered a second-generation oxazolidinone derivative that is more potent against MRSA and VRE?

What is a significant advantage of Fosfomycin when compared to other antibiotics?

How does Fosfomycin primarily exert its antibiotic effect?

Fosfomycin

Rapid bactericidal effect and wide antibacterial spectrum including MRSA, VRE, and many Gram-negative bacteria
Used to treat urinary tract infections and cystitis in women
Side effects: Nephrotoxicity

Protein Synthesis Inhibitors

Inhibit either the 30S or 50S ribosomal subunit, which differs from mammalian ones
Can be bactericidal or bacteriostatic depending on the type of binding
Classification: Macrolides, Clindamycin, Chloramphenicol, Aminoglycosides, Tetracyclins, and Linazolid

Aminoglycosides

Bactericidal
Examples: Amikacin, Gentamicin, Tobramycin, Streptomycin, Neomycin, and Kanamycin
Uses: Broad-spectrum antibiotics, used in pseudomonal infections and in the treatment of tuberculosis
Toxicity: Nephrotoxicity and Ototoxicity

Tetracyclines

Bacteriostatic
Act by reversibly binding to the 30S subunit of the ribosome at the A-site
Examples: Oxytetracycline, Minocycline, Doxycycline
Uses: Treat rosacea, prevent rhinophyma, and cover atypical bacteria, Gram-positive, and Gram-negative bacteria
Spectrum: Includes Mycoplasma, Chlamydia, Rickettsiae, and Spirochetes, but not active against S. pyogenes and P. aeruginosa

Lincosamides

Bacteriostatic
Examples: Lincomycin, Clindamycin
Uses: Effective against anaerobes, Gram-positive cocci, and MRSA
Side effects: Pseudomembranous Colitis

Oxazolidinones

Bacteriostatic
Examples: Linezolid
Uses: Active against Gram-positive bacteria, including VRE and MRSA, and can be used in people with liver disease or poor kidney function
Side effects: Long-term usage (>2 weeks) may be associated with low platelet count
Tedizolid is a second-generation oxazolidinone derivative that is 4-to-16-fold more potent against MRSA and VRE

Test your knowledge on Fosfomycin Streptomyces wedmorensis, an antibiotic with rapid bactericidal effect against MRSA, VRE, and Gram-negative bacteria. Explore its uses in treating skin infections and urinary tract infections, along with potential side effects.