Podcast
Questions and Answers
Which sweetening agent is commonly used with polyols?
Which sweetening agent is commonly used with polyols?
What is the optimum concentration of ethyl alcohol for bactericidal activity?
What is the optimum concentration of ethyl alcohol for bactericidal activity?
Which of the following is an example of an artificial preservative?
Which of the following is an example of an artificial preservative?
What is the primary function of antioxidants in pharmaceutical formulations?
What is the primary function of antioxidants in pharmaceutical formulations?
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Which of these statements is true about the storage conditions for formulations?
Which of these statements is true about the storage conditions for formulations?
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What is the concentration range of tocopherols used in pharmaceutical products?
What is the concentration range of tocopherols used in pharmaceutical products?
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Which of the following preservatives is most effective against yeasts and molds?
Which of the following preservatives is most effective against yeasts and molds?
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At what pH level does potassium benzoate exhibit maximum preservative efficacy?
At what pH level does potassium benzoate exhibit maximum preservative efficacy?
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Which of the following tocopherols is considered a source of vitamin E?
Which of the following tocopherols is considered a source of vitamin E?
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What is a common characteristic of propyl paraben in its applications?
What is a common characteristic of propyl paraben in its applications?
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Study Notes
Sweetening Agents
- Used to mask unpleasant tastes
- Sucrose is commonly used between pH 4 and 8 and combined with polyols
- Liquid glucose is made through starch hydrolysis
Antioxidants
- Prevent drug degradation from oxidation
- Examples include vitamin E, vitamin C, butylated hydroxyanisole, butylated hydroxytoluene
Antimicrobial Agents
- Effective against gram-positive and gram-negative microorganisms
- Examples include sodium benzoate, sorbates, methyl paraben, propyl paraben
Preservative/Chelating Agents
- Prevent formulation degradation by forming complexes with ingredients
- Examples include EDTA, polyphosphates, and citric acid
Natural Preservatives
- Derived from plants, minerals, and animals
- Neem oil, sodium chloride, lemon, and honey are examples
Artificial Preservatives
- Chemically synthesized
- Examples include benzoates, sodium benzoate, sorbates, propionates, and nitrites
Ethyl Alcohol
- Bactericidal in aqueous solutions at concentrations between 60% and 95% (v/v)
- Optimum concentration is 70% (v/v)
- Inactivated by nonionic surfactants and ineffective against bacterial spores
Flavoring Agents
- Often heat-sensitive and volatile
- Typically used at 0.5-0.75% concentration
- Choices depend on patient preference and age, with children often preferring sweeter preparations
- Storage temperature should be between 15-30°C with 45% relative humidity
Tocopherol
- Alpha tocopherol is a source of vitamin E and a commercially available preservative
- Beta, delta, and gamma tocopherol are more effective antioxidants
- Used in pharmaceutical products at 0.001-0.05% (v/v) concentration
Sodium Benzoate
- Used as a preservative effective at 0.02-0.5% in oral medicines, 0.5% in parenteral products, and 0.1-0.5% in cosmetics
- Effective over a narrow pH range
- Preferred to benzoic acid due to higher solubility
- Can impart an unpleasant taste
Potassium Benzoate
- Preservative efficacy increases as pH decreases
- Most effective below pH 4.5
- Undissociated benzoic acid may produce a perceptible taste at very low pH
Methyl Paraben
- Most effective against yeasts and molds across a wide pH range
- Broad-spectrum antimicrobial activity at 2-5%
- Preservative efficacy improved by the addition of propylene glycol (2-5%) or combined with other parabens
- Used as an alternative to sodium benzoate when low sodium content is desirable
Propyl Paraben
- Typically used in water-based cosmetics
- Acts as an antifungal and antimicrobial agent
Unit Operations
- Involves a physical change or chemical transformation
- Examples include separation, crystallization, evaporation, filtration, polymerization, isomerization, and other reactions
- Objectives include transforming substances from one form to another
Objectives and Applications of Unit Operations
- Transform various forms of substances from a fluid
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Description
Test your knowledge on various food preservation methods and additives. This quiz covers sweetening agents, antioxidants, antimicrobial agents, and both natural and artificial preservatives. Understand how these substances contribute to food safety and longevity.