Folic Acid and Purine Analog Quiz
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Questions and Answers

Which drug inhibits dihydrofolate reductase and decreases synthesis of dTMP, RNA, and protein?

  • Methotrexate (correct)
  • 6-Mercaptopurine
  • Azathioprine
  • 5-Fluorouracil
  • Which drug induces mutations by pairing with both cytosine and thymine, and inhibits de novo purine synthesis?

  • Azathioprine
  • 6-Thioguanine (correct)
  • 5-Fluorouracil
  • Methotrexate
  • Which drug binds thymidylate synthase and decreases dTMP, and is used for solid tumors like lung, breast, and ovary?

  • Azathioprine
  • 5-Fluorouracil (correct)
  • 6-Mercaptopurine
  • Methotrexate
  • Which drug is a pyrimidine analog that specifically inhibits thymidylate synthase?

    <p>Methotrexate</p> Signup and view all the answers

    Which drug is a monoclonal antibody that prevents EGF binding to the receptor?

    <p>Cetuximab</p> Signup and view all the answers

    Which drug is a monoclonal antibody against VEGF and acts as an angiogenesis inhibitor?

    <p>Bevacizumab</p> Signup and view all the answers

    Which drug is a monoclonal antibody that blocks CTLA-4?

    <p>Ipilimumab</p> Signup and view all the answers

    Which drug is a monoclonal antibody that blocks PD-1?

    <p>Pembrolizumab</p> Signup and view all the answers

    Which drug is used for metastatic renal cell carcinoma and metastatic malignant melanoma?

    <p>Ipilimumab</p> Signup and view all the answers

    Which drug is a B-RAF inhibitor used for late-stage melanoma?

    <p>Vemurafenib</p> Signup and view all the answers

    Which drug is an epigenetic target used for myelodysplastic syndrome ('preleukemia')?

    <p>5-Azacytidine</p> Signup and view all the answers

    Which drug is an immunotherapy used for metastatic colorectal cancer and lung cancer - NSCLC?

    <p>Pembrolizumab</p> Signup and view all the answers

    Which drug inhibits topoisomerase II and thereby induces double-strand DNA breaks?

    <p>Etoposide</p> Signup and view all the answers

    Which drug stabilizes microtubules of the mitotic spindle?

    <p>Paclitaxel</p> Signup and view all the answers

    Which drug is known for its addition of alkyl group and cross-linking DNA at Guanine residues?

    <p>Cyclophosphamide</p> Signup and view all the answers

    Which drug is used to treat metastatic ovarian cancer and colorectal cancer?

    <p>Topotecan</p> Signup and view all the answers

    Which drug is an estrogen receptor antagonist in breast but also a partial agonist in some other organs?

    <p>Tamoxifen</p> Signup and view all the answers

    Which drug prevents conversion of testosterone to estradiol and is used in advanced breast cancer?

    <p>Letrozole</p> Signup and view all the answers

    Which drug is a kinase inhibitor that inhibits HER2 and EGFR?

    <p>Lapatinib</p> Signup and view all the answers

    Which drug is an agonist of retinoic acid receptor and is used in the treatment of Acute Promyelocytic Leukemia?

    <p>ATRA</p> Signup and view all the answers

    Which drug inhibits CYP17A1 and androgen synthesis, and is used in castration-resistant prostate cancer?

    <p>Abiraterone</p> Signup and view all the answers

    Which drug is known for its fluid retention and is used in the treatment of HER2-positive breast cancer?

    <p>Trastuzumab</p> Signup and view all the answers

    Which drug intercalates into DNA and inhibits DNA replication and transcription?

    <p>Doxorubicin</p> Signup and view all the answers

    Which drug is a topoisomerase I inhibitor and leads to single-strand DNA breaks?

    <p>Irinotecan</p> Signup and view all the answers

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