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Questions and Answers
What is the main mechanism of action of purine analogs like 6-Mercaptopurine and 6-Thioguanine?
What is the main mechanism of action of purine analogs like 6-Mercaptopurine and 6-Thioguanine?
- They inhibit the activity of topoisomerase enzymes, leading to DNA damage.
- They intercalate into DNA, preventing transcription and replication.
- They inhibit the synthesis of DNA by interfering with the biosynthesis of purine bases. (correct)
- They alkylate and crosslink DNA strands, leading to cell death.
Which of the following is a common adverse effect of purine analog drugs like 6-Mercaptopurine and 6-Thioguanine?
Which of the following is a common adverse effect of purine analog drugs like 6-Mercaptopurine and 6-Thioguanine?
- Bone marrow suppression (correct)
- Neurotoxicity
- Cardiotoxicity
- Hepatorenal toxicity
Why is allopurinol often given to patients receiving cancer chemotherapy with drugs like 6-Mercaptopurine?
Why is allopurinol often given to patients receiving cancer chemotherapy with drugs like 6-Mercaptopurine?
- Allopurinol inhibits xanthine oxidase, which metabolizes 6-Mercaptopurine, leading to higher plasma levels.
- Allopurinol enhances the antitumor activity of 6-Mercaptopurine by inhibiting purine synthesis.
- Allopurinol protects against the cardiotoxic effects of 6-Mercaptopurine.
- Allopurinol prevents the formation of uric acid, which can lead to gout and kidney stones during chemotherapy. (correct)
Which of the following is a potential drug interaction with methotrexate that can lead to toxicity?
Which of the following is a potential drug interaction with methotrexate that can lead to toxicity?
How can toxicity from methotrexate be managed?
How can toxicity from methotrexate be managed?
Which of the following leukemias is 6-Thioguanine commonly used to treat?
Which of the following leukemias is 6-Thioguanine commonly used to treat?
Which enzyme does methotrexate inhibit in mammalian cells?
Which enzyme does methotrexate inhibit in mammalian cells?
What is the primary dose-limiting toxicity of methotrexate and pemetrexed?
What is the primary dose-limiting toxicity of methotrexate and pemetrexed?
Which drug is indicated for the treatment of non–small cell lung cancer and mesothelioma, in combination with cisplatin?
Which drug is indicated for the treatment of non–small cell lung cancer and mesothelioma, in combination with cisplatin?
What is the management strategy known as leucovorin rescue used for?
What is the management strategy known as leucovorin rescue used for?
What adverse effect can long-term use of methotrexate cause?
What adverse effect can long-term use of methotrexate cause?
How can alkalinization of urine help in reducing methotrexate toxicity?
How can alkalinization of urine help in reducing methotrexate toxicity?
What is the mechanism of action of nitrogen mustard prodrugs like cyclophosphamide and ifosfamide?
What is the mechanism of action of nitrogen mustard prodrugs like cyclophosphamide and ifosfamide?
Which type of cancer is non-Hodgkin lymphoma commonly treated with?
Which type of cancer is non-Hodgkin lymphoma commonly treated with?
What adverse effect is commonly associated with nitrogen mustard agents like cyclophosphamide and ifosfamide?
What adverse effect is commonly associated with nitrogen mustard agents like cyclophosphamide and ifosfamide?
Which sulfhydryl compound is often coadministered to prevent hemorrhagic cystitis caused by nitrogen mustard agents?
Which sulfhydryl compound is often coadministered to prevent hemorrhagic cystitis caused by nitrogen mustard agents?
Which platinum analog is used to treat colorectal cancer?
Which platinum analog is used to treat colorectal cancer?
What is the main adverse effect associated with cisplatin among the platinum analogs?
What is the main adverse effect associated with cisplatin among the platinum analogs?
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