18 Questions
What is the main mechanism of action of purine analogs like 6-Mercaptopurine and 6-Thioguanine?
They inhibit the synthesis of DNA by interfering with the biosynthesis of purine bases.
Which of the following is a common adverse effect of purine analog drugs like 6-Mercaptopurine and 6-Thioguanine?
Bone marrow suppression
Why is allopurinol often given to patients receiving cancer chemotherapy with drugs like 6-Mercaptopurine?
Allopurinol prevents the formation of uric acid, which can lead to gout and kidney stones during chemotherapy.
Which of the following is a potential drug interaction with methotrexate that can lead to toxicity?
Concomitant use of NSAIDs like aspirin
How can toxicity from methotrexate be managed?
All of the above
Which of the following leukemias is 6-Thioguanine commonly used to treat?
Acute myeloid leukemia
Which enzyme does methotrexate inhibit in mammalian cells?
Dihydrofolate reductase
What is the primary dose-limiting toxicity of methotrexate and pemetrexed?
Myelosuppression
Which drug is indicated for the treatment of non–small cell lung cancer and mesothelioma, in combination with cisplatin?
Pemetrexed
What is the management strategy known as leucovorin rescue used for?
Reducing methotrexate toxicity to normal cells
What adverse effect can long-term use of methotrexate cause?
Hepatotoxicity
How can alkalinization of urine help in reducing methotrexate toxicity?
Reduce renal toxicity
What is the mechanism of action of nitrogen mustard prodrugs like cyclophosphamide and ifosfamide?
Require activation by hepatic cytochrome P450 enzymes
Which type of cancer is non-Hodgkin lymphoma commonly treated with?
Breast cancer
What adverse effect is commonly associated with nitrogen mustard agents like cyclophosphamide and ifosfamide?
Hemorrhagic cystitis
Which sulfhydryl compound is often coadministered to prevent hemorrhagic cystitis caused by nitrogen mustard agents?
2-mercaptoethanesulfonate (Mesna)
Which platinum analog is used to treat colorectal cancer?
Oxaliplatin
What is the main adverse effect associated with cisplatin among the platinum analogs?
Nephrotoxicity
This quiz covers the specific agents Methotrexate and Pemetrexed, their mechanism of action as folic acid antagonists, and how they inhibit enzymes involved in DNA synthesis. Test your knowledge on these important chemotherapy drugs.
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