Podcast
Questions and Answers
Which condition is NOT considered a cause of folate deficiency?
Which condition is NOT considered a cause of folate deficiency?
- Crohn's disease
- Hypertension (correct)
- Liver disease
- Haemolytic anaemias
Which physical condition can lead to excess utilization of folate?
Which physical condition can lead to excess utilization of folate?
- Lactation (correct)
- Chronic kidney disease
- Hypothyroidism
- Chronic obstructive pulmonary disease
What type of dietary issue is likely to contribute to folate deficiency?
What type of dietary issue is likely to contribute to folate deficiency?
- Excessive vitamin B12 intake
- Balanced high-protein diet
- Increased calcium intake
- Poverty leading to inadequate nutrition (correct)
Which medication is associated with an increased risk of folate deficiency?
Which medication is associated with an increased risk of folate deficiency?
Excess urinary folate loss can be caused by which condition?
Excess urinary folate loss can be caused by which condition?
Flashcards
Folate Deficiency: Nutritional Causes
Folate Deficiency: Nutritional Causes
Folate deficiency can arise from poor diet, especially in older people, those in institutions, or during poverty/famine, specific diets, or diseases like goat's milk anaemia.
Folate Deficiency: Malabsorption
Folate Deficiency: Malabsorption
Impaired absorption of folate from the gut can lead to deficiency. This is seen in conditions like tropical sprue, gluten intolerance, and some surgeries (partial gastrectomy).
Folate Deficiency: Excess Utilization (Physiological)
Folate Deficiency: Excess Utilization (Physiological)
Increased folate needs during pregnancy and breastfeeding, or in premature babies, may lead to deficiency if intake isn't high enough.
Folate Deficiency: Excess Utilization (Pathological)
Folate Deficiency: Excess Utilization (Pathological)
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Folate Deficiency: Drug-Induced
Folate Deficiency: Drug-Induced
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Study Notes
Causes of Folate Deficiency
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Nutritional Deficiencies: Old age, institutions, poverty, famine, and special diets (like goat's milk) can lead to folate deficiency.
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Malabsorption: Conditions like tropical sprue and gluten-induced enteropathy can cause folate malabsorption. Partial gastrectomy or extensive jejunal resection, especially in patients with Crohn's disease, can also contribute.
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Excess Utilization:
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Physiological: Pregnancy, lactation, and prematurity increase the body's need for folate.
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Pathological: Haematological diseases (like haemolytic anaemia and myelofibrosis), malignant diseases (like carcinoma, lymphoma, and myeloma), and inflammatory diseases (Crohn's disease, tuberculosis, rheumatoid arthritis, psoriasis, and exfoliative dermatitis) can increase folate use.
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Excess Urinary Loss: Active liver disease and congestive heart failure can cause excessive urinary folate loss.
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Drugs: Anticonvulsants and sulfasalazine can interfere with folate absorption.
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Mixed Causes: Liver disease, alcoholism, and intensive care can contribute to folate deficiency, often in combination with other factors.
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