Questions and Answers
What is Fluphenazine (Prolixin) primarily classified as?
What are the routes of administration for Fluphenazine (Prolixin)?
IM, PO
What is one indication for using Fluphenazine (Prolixin)?
Acute and chronic psychoses
Which of the following are side effects of Fluphenazine (Prolixin)? (Select all that apply)
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What should be monitored in patients taking Fluphenazine (Prolixin)?
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What is the primary action of Fluphenazine (Prolixin)?
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Fluphenazine is contraindicated for use in patients with liver disease.
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Which conditions require caution when using Fluphenazine (Prolixin)? (Select all that apply)
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Name one drug interaction with Fluphenazine (Prolixin).
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Study Notes
Fluphenazine (Prolixin) Overview
- Fluphenazine, commercially known as Prolixin, is available in both oral (PO) hydrochloride and intramuscular (IM) decanoate forms.
Drug Classification and Pharmacokinetics
- Classified as a phenothiazine antipsychotic.
- Pregnancy Category C; safety in pregnancy not established.
- Routes of administration include IM and PO.
- Highly metabolized by the liver with over 90% protein binding.
- Half-life ranges from 33 hours to 9.6 days.
Indications
- Primarily indicated for the management of acute and chronic psychoses.
Side Effects
- Serious side effects include neuroleptic malignant syndrome and agranulocytosis.
- Common reactions: extrapyramidal symptoms, sedation, blurred vision, and dry mouth.
- Other notable effects: hypertension, hypotension, increased heart rate, weight gain, constipation, nausea, and urinary retention.
- Allergic reactions can occur, along with rash, galactorrhea, and changes in pigmentation.
Nursing Responsibilities
- Rarely prescribed for pediatric patients; monitoring of vital signs is essential.
- Keeping track of adverse reactions and body mass index (BMI) is important.
- If stable, IM may be administered for non-compliant patients, with an alternative IM option available every four weeks.
Mechanism of Action
- Fluphenazine alters dopamine effects in the central nervous system (CNS) and exerts anticholinergic and alpha-adrenergic blocking activities.
Contraindications
- Not suitable for individuals with hypersensitivity, severe CNS depression, liver disease, or those allergic to sesame oil.
- Caution in patients with subcortical brain damage, coma, and concurrent use of QT-prolonging drugs.
Cautions
- Use with caution in patients with cardiovascular disease, Parkinson's disease, angle-closure glaucoma, myasthenia gravis, and prostatic hypertrophy.
- Advisable to discontinue usage during lactation; safety during pregnancy is not verified.
Drug Interactions
- Risks of arrhythmias increase when combined with drugs that prolong the QT interval (e.g., antiarrhythmics, methadone).
- Caution against combining with antihypertensives and CNS depressants (alcohol, antidepressants).
- Sedatives may reduce Fluphenazine’s effectiveness, while lithium toxicity may be enhanced.
- Antacids can lower absorption, and concurrent anticholinergic drugs may amplify anticholinergic effects.
- Metoclopramide can heighten the risk of extrapyramidal symptoms.
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Description
Test your knowledge on Fluphenazine, also known as Prolixin, with these flashcards. Covering drug classification, routes of administration, and indications, this quiz is perfect for medical students and professionals. Enhance your understanding of this important antipsychotic medication.
