Podcast
Questions and Answers
What is the drug classification of Prolixin?
What is the drug classification of Prolixin?
The recommended dose range for fluphenazine hydrochloride oral use is between ___ mg/day.
The recommended dose range for fluphenazine hydrochloride oral use is between ___ mg/day.
0.5-10
What is the pharmacological action of Prolixin?
What is the pharmacological action of Prolixin?
Alters the effects of dopamine in the CNS and has anticholinergic and alpha-adrenergic blocking activity.
Which of the following is NOT a side effect of Prolixin?
Which of the following is NOT a side effect of Prolixin?
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What are some medication/food interactions to be aware of when taking Prolixin?
What are some medication/food interactions to be aware of when taking Prolixin?
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Patients with closed-angle glaucoma should take Prolixin with caution.
Patients with closed-angle glaucoma should take Prolixin with caution.
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What are the therapeutic uses of Prolixin?
What are the therapeutic uses of Prolixin?
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Which of the following should patients be advised to do to prevent orthostatic hypotension while taking Prolixin?
Which of the following should patients be advised to do to prevent orthostatic hypotension while taking Prolixin?
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A decrease in ___, ___, or ___ behavior can indicate the effectiveness of Prolixin.
A decrease in ___, ___, or ___ behavior can indicate the effectiveness of Prolixin.
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Which caution should be taken when administering Prolixin to patients?
Which caution should be taken when administering Prolixin to patients?
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Study Notes
Drug Classification
- Prolixin (fluphenazine) is classified as a conventional antipsychotic.
Dose Range
- Fluphenazine hydrochloride dosage:
- Oral: 0.5-10 mg/day in divided doses every 6-8 hours; maximum dose of 40 mg/day.
- Intramuscular: 1.25-2.5 mg every 6-8 hours.
- Fluphenazine decanoate dosage (depot injection):
- Initial dose: 12.5-25 mg, repeated every 3 weeks; doses may be slowly increased, not exceeding 100 mg per dose.
Pharmacological Action
- Alters dopamine effects in the central nervous system (CNS).
- Exhibits anticholinergic and alpha-adrenergic blocking activities.
Side Effects
- Potentially severe side effects include:
- Neuroleptic malignant syndrome and extrapyramidal reactions.
- Sedation, tardive dyskinesia, blurred vision, hypertension.
- Gastrointestinal issues: anorexia, constipation, dry mouth.
- Urinary retention, peripheral edema, impaired thermoregulation.
- Convulsions and agranulocytosis.
Medication/Food Interactions
- Risks increase when administered with drugs that prolong the QT interval.
- Anti-hypertensives can exacerbate hypotension.
- Concurrent CNS depressants, including alcohol and lithium, can lead to increased CNS depression.
- Sesame oil may interact with the medication.
Nursing Administration Concerns
- Caution advised for patients in a coma, with bone marrow depression, subcortical brain damage, or severe CNS depression.
- Do not mix medication with caffeine-containing beverages.
- Monitor patients for signs of akathisia, extrapyramidal symptoms (EPS), and tardive dyskinesia.
- Use caution with patients having cardiovascular disease, Parkinson's disease, closed-angle glaucoma, or seizure disorders.
Therapeutic Uses
- Primarily used for the treatment of acute and chronic psychoses.
Nursing Interventions/Client Education
- Instruct patients to take the medication as directed.
- Educate on the possibility of extrapyramidal symptoms and proper precautions.
- Advise avoiding alcohol or other CNS depressants to reduce risks.
- Encourage the use of sunscreen due to photosensitivity.
- Recommend slowly changing positions to prevent orthostatic hypotension.
- Warn about drowsiness; caution against driving during treatment.
- Rinse mouth to alleviate dry mouth symptoms.
Evaluation of Medication Effectiveness
- Desired outcomes include a decrease in excitable, paranoid, or withdrawn behaviors.
- Improvement indicated by reduced signs and symptoms of psychoses.
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Description
This quiz covers the classification, dosage ranges, and pharmacological actions of Fluphenazine, a conventional antipsychotic. It will also address potential side effects and medication interactions. Test your knowledge about this essential medication used in treating psychiatric conditions.
