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Drug Classification of Fluphenazine
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Drug Classification of Fluphenazine

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Questions and Answers

What is the drug classification of Prolixin?

  • Mood stabilizer
  • Benzodiazepine
  • Antidepressant
  • Conventional antipsychotic (correct)
  • The recommended dose range for fluphenazine hydrochloride oral use is between ___ mg/day.

    0.5-10

    What is the pharmacological action of Prolixin?

    Alters the effects of dopamine in the CNS and has anticholinergic and alpha-adrenergic blocking activity.

    Which of the following is NOT a side effect of Prolixin?

    <p>Weight gain</p> Signup and view all the answers

    What are some medication/food interactions to be aware of when taking Prolixin?

    <p>Concurrent use with drugs that prolong QT interval, anti-hypertensives, increased CNS depression with other CNS depressants, alcohol, lithium, and sesame oil.</p> Signup and view all the answers

    Patients with closed-angle glaucoma should take Prolixin with caution.

    <p>True</p> Signup and view all the answers

    What are the therapeutic uses of Prolixin?

    <p>Acute and chronic psychoses.</p> Signup and view all the answers

    Which of the following should patients be advised to do to prevent orthostatic hypotension while taking Prolixin?

    <p>Change positions slowly</p> Signup and view all the answers

    A decrease in ___, ___, or ___ behavior can indicate the effectiveness of Prolixin.

    <p>excitable, paranoiac, withdrawn</p> Signup and view all the answers

    Which caution should be taken when administering Prolixin to patients?

    <p>Monitor for onset of akathisia, EPS, tardive dyskinesia.</p> Signup and view all the answers

    Study Notes

    Drug Classification

    • Prolixin (fluphenazine) is classified as a conventional antipsychotic.

    Dose Range

    • Fluphenazine hydrochloride dosage:
      • Oral: 0.5-10 mg/day in divided doses every 6-8 hours; maximum dose of 40 mg/day.
      • Intramuscular: 1.25-2.5 mg every 6-8 hours.
    • Fluphenazine decanoate dosage (depot injection):
      • Initial dose: 12.5-25 mg, repeated every 3 weeks; doses may be slowly increased, not exceeding 100 mg per dose.

    Pharmacological Action

    • Alters dopamine effects in the central nervous system (CNS).
    • Exhibits anticholinergic and alpha-adrenergic blocking activities.

    Side Effects

    • Potentially severe side effects include:
      • Neuroleptic malignant syndrome and extrapyramidal reactions.
      • Sedation, tardive dyskinesia, blurred vision, hypertension.
      • Gastrointestinal issues: anorexia, constipation, dry mouth.
      • Urinary retention, peripheral edema, impaired thermoregulation.
      • Convulsions and agranulocytosis.

    Medication/Food Interactions

    • Risks increase when administered with drugs that prolong the QT interval.
    • Anti-hypertensives can exacerbate hypotension.
    • Concurrent CNS depressants, including alcohol and lithium, can lead to increased CNS depression.
    • Sesame oil may interact with the medication.

    Nursing Administration Concerns

    • Caution advised for patients in a coma, with bone marrow depression, subcortical brain damage, or severe CNS depression.
    • Do not mix medication with caffeine-containing beverages.
    • Monitor patients for signs of akathisia, extrapyramidal symptoms (EPS), and tardive dyskinesia.
    • Use caution with patients having cardiovascular disease, Parkinson's disease, closed-angle glaucoma, or seizure disorders.

    Therapeutic Uses

    • Primarily used for the treatment of acute and chronic psychoses.

    Nursing Interventions/Client Education

    • Instruct patients to take the medication as directed.
    • Educate on the possibility of extrapyramidal symptoms and proper precautions.
    • Advise avoiding alcohol or other CNS depressants to reduce risks.
    • Encourage the use of sunscreen due to photosensitivity.
    • Recommend slowly changing positions to prevent orthostatic hypotension.
    • Warn about drowsiness; caution against driving during treatment.
    • Rinse mouth to alleviate dry mouth symptoms.

    Evaluation of Medication Effectiveness

    • Desired outcomes include a decrease in excitable, paranoid, or withdrawn behaviors.
    • Improvement indicated by reduced signs and symptoms of psychoses.

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    Description

    This quiz covers the classification, dosage ranges, and pharmacological actions of Fluphenazine, a conventional antipsychotic. It will also address potential side effects and medication interactions. Test your knowledge about this essential medication used in treating psychiatric conditions.

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