Questions and Answers
What is the drug classification of Prolixin?
The recommended dose range for fluphenazine hydrochloride oral use is between ___ mg/day.
0.5-10
What is the pharmacological action of Prolixin?
Alters the effects of dopamine in the CNS and has anticholinergic and alpha-adrenergic blocking activity.
Which of the following is NOT a side effect of Prolixin?
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What are some medication/food interactions to be aware of when taking Prolixin?
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Patients with closed-angle glaucoma should take Prolixin with caution.
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What are the therapeutic uses of Prolixin?
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Which of the following should patients be advised to do to prevent orthostatic hypotension while taking Prolixin?
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A decrease in ___, ___, or ___ behavior can indicate the effectiveness of Prolixin.
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Which caution should be taken when administering Prolixin to patients?
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Study Notes
Drug Classification
- Prolixin (fluphenazine) is classified as a conventional antipsychotic.
Dose Range
- Fluphenazine hydrochloride dosage:
- Oral: 0.5-10 mg/day in divided doses every 6-8 hours; maximum dose of 40 mg/day.
- Intramuscular: 1.25-2.5 mg every 6-8 hours.
- Fluphenazine decanoate dosage (depot injection):
- Initial dose: 12.5-25 mg, repeated every 3 weeks; doses may be slowly increased, not exceeding 100 mg per dose.
Pharmacological Action
- Alters dopamine effects in the central nervous system (CNS).
- Exhibits anticholinergic and alpha-adrenergic blocking activities.
Side Effects
- Potentially severe side effects include:
- Neuroleptic malignant syndrome and extrapyramidal reactions.
- Sedation, tardive dyskinesia, blurred vision, hypertension.
- Gastrointestinal issues: anorexia, constipation, dry mouth.
- Urinary retention, peripheral edema, impaired thermoregulation.
- Convulsions and agranulocytosis.
Medication/Food Interactions
- Risks increase when administered with drugs that prolong the QT interval.
- Anti-hypertensives can exacerbate hypotension.
- Concurrent CNS depressants, including alcohol and lithium, can lead to increased CNS depression.
- Sesame oil may interact with the medication.
Nursing Administration Concerns
- Caution advised for patients in a coma, with bone marrow depression, subcortical brain damage, or severe CNS depression.
- Do not mix medication with caffeine-containing beverages.
- Monitor patients for signs of akathisia, extrapyramidal symptoms (EPS), and tardive dyskinesia.
- Use caution with patients having cardiovascular disease, Parkinson's disease, closed-angle glaucoma, or seizure disorders.
Therapeutic Uses
- Primarily used for the treatment of acute and chronic psychoses.
Nursing Interventions/Client Education
- Instruct patients to take the medication as directed.
- Educate on the possibility of extrapyramidal symptoms and proper precautions.
- Advise avoiding alcohol or other CNS depressants to reduce risks.
- Encourage the use of sunscreen due to photosensitivity.
- Recommend slowly changing positions to prevent orthostatic hypotension.
- Warn about drowsiness; caution against driving during treatment.
- Rinse mouth to alleviate dry mouth symptoms.
Evaluation of Medication Effectiveness
- Desired outcomes include a decrease in excitable, paranoid, or withdrawn behaviors.
- Improvement indicated by reduced signs and symptoms of psychoses.
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Description
This quiz covers the classification, dosage ranges, and pharmacological actions of Fluphenazine, a conventional antipsychotic. It will also address potential side effects and medication interactions. Test your knowledge about this essential medication used in treating psychiatric conditions.
