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Questions and Answers
Which antibiotic is often effective in treating infections unresponsive to B-lactam antibiotics?
Why is Ciprofloxacin not the drug of first choice for pneumonia or sinusitis?
Why are Levofloxacin and moxifloxacin known as 'respiratory fluoroquinolones'?
What is the main reason for selecting the combination of trimethoprim with sulfamethoxazole in co-trimoxazole?
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Which condition is co-trimoxazole effective in treating?
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Which condition is sulfasalazin (sulfapyridine and 5-aminosalicylate) primarily used to treat?
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What is the recommended dosage of co-trimoxazole for uncomplicated lower urinary tract infections?
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What is the purpose of combining sulfadiazine with pyrimethamine?
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Study Notes
Antibiotic Treatments
- Aminoglycosides are often effective for infections unresponsive to β-lactam antibiotics.
- Ciprofloxacin is not a first-choice drug for pneumonia or sinusitis due to its lower efficacy against the typical pathogens causing these infections, particularly Streptococcus pneumoniae.
- Levofloxacin and moxifloxacin are termed 'respiratory fluoroquinolones' because they are effective against common respiratory pathogens and have enhanced activity against gram-positive bacteria, including Streptococcus pneumoniae.
Co-trimoxazole and Sulfasalazine
- The combination of trimethoprim with sulfamethoxazole in co-trimoxazole improves antimicrobial efficacy; trimethoprim enhances the effect of sulfamethoxazole, leading to a synergistic action.
- Co-trimoxazole is commonly effective in treating uncomplicated urinary tract infections.
- Sulfasalazine, which consists of sulfapyridine and 5-aminosalicylate, is primarily used to treat inflammatory bowel diseases such as ulcerative colitis and Crohn's disease.
Dosage and Combinations
- The recommended dosage of co-trimoxazole for uncomplicated lower urinary tract infections is typically 160 mg of trimethoprim and 800 mg of sulfamethoxazole, usually administered twice daily.
- Sulfadiazine is combined with pyrimethamine to treat toxoplasmosis, resulting in synergistic effects that enhance the treatment's effectiveness.
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Description
Test your knowledge of fluoroquinolone antibiotics and their effectiveness in treating resistant respiratory infections with this quiz. Evaluate your understanding of drugs like Levofloxacin and Ciprofloxacin in managing conditions like pneumonia and sinusitis, and learn about their activity against common causative agents.
