Fluid Balance and Imbalances

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Questions and Answers

How does Atrial Natriuretic Peptide (ANP) contribute to fluid balance in the body?

  • By increasing sodium reabsorption in the kidneys, leading to fluid retention.
  • By promoting sodium excretion, increasing urine output, and inhibiting the renin-angiotensin-aldosterone system. (correct)
  • By stimulating the renin-angiotensin-aldosterone system, which increases blood pressure.
  • By inhibiting urine output, which helps to conserve fluid volume.

Blockage of lymphatic vessels by filarial worms is the primary cause of which condition?

  • Ascites
  • Liver cirrhosis
  • Nephrotic syndrome
  • Elephantiasis (correct)

In a state of fluid overload, what change would be expected in the serum sodium concentration?

  • The sodium concentration increases due to increased sodium intake.
  • The sodium concentration remains unchanged regardless of fluid volume.
  • The sodium concentration decreases due to the dilution of water (correct)
  • The sodium concentration fluctuates erratically without a predictable pattern.

Which laboratory test is most accurate for assessing dehydration status by measuring the proportion of red blood cells in the blood?

<p>Hematocrit (A)</p> Signup and view all the answers

How does Angiotensin II typically affect blood pressure?

<p>By causing vasoconstriction leading to increased blood pressure. (A)</p> Signup and view all the answers

Considering total body water distribution, which fluid compartment contains the majority of water?

<p>Intracellular Fluid (ICF) (D)</p> Signup and view all the answers

Which condition directly impairs the kidney's ability to maintain oncotic pressure, leading to edema?

<p>Nephrotic Syndrome (A)</p> Signup and view all the answers

Which of the following conditions affects the liver's ability to synthesize proteins, leading to decreased oncotic pressure and potential fluid imbalance?

<p>Liver Cirrhosis (C)</p> Signup and view all the answers

During assessment of fluid volume status, which veins are most commonly examined to detect fluid excess?

<p>Jugular Veins (C)</p> Signup and view all the answers

Why might a pregnant woman experience edema particularly during the third trimester?

<p>Due to compression of the inferior vena cava by the growing uterus. (C)</p> Signup and view all the answers

What metabolic byproduct contributes to hangover symptoms after alcohol consumption?

<p>Acetaldehyde (A)</p> Signup and view all the answers

Which of the following is the MOST accurate method for confirming an HIV infection?

<p>Western Blot (D)</p> Signup and view all the answers

What enzyme is crucial for HIV's replication process, allowing it to convert its RNA into DNA for integration into the host cell's genome?

<p>Reverse Transcriptase (B)</p> Signup and view all the answers

What opportunistic neoplasm is frequently observed in patients with HIV, especially those with advanced stages of the disease?

<p>Kaposi Sarcoma (B)</p> Signup and view all the answers

What is the typical range of CD4+ T-cell count in a healthy, immunocompetent adult?

<p>600-1200 cells/mm³ (D)</p> Signup and view all the answers

A patient with HIV is considered to have progressed to AIDS when their CD4+ T-cell count falls below what level?

<p>200 cells/mm³ (B)</p> Signup and view all the answers

Following a splenectomy, individuals are at increased risk for infection by which type of bacteria?

<p>Streptococcus pneumoniae (B)</p> Signup and view all the answers

Besides sexual contact, which of the following is a confirmed mode for HIV transmission?

<p>Blood transfusion (D)</p> Signup and view all the answers

Individuals of African descent with AIDS are most commonly infected with which subtype of HIV?

<p>HIV 2 (B)</p> Signup and view all the answers

Which type of immune cell is the primary target and is subsequently destroyed by the Human Immunodeficiency Virus (HIV)?

<p>Helper T Cells (B)</p> Signup and view all the answers

Flashcards

Role of ANP

Maintains fluid balance by promoting sodium excretion, increasing urine output, and inhibiting the renin-angiotensin-aldosterone system.

Elephantiasis

Disease condition where filarial worms obstruct lymphatic vessels causing edema.

Ascites

Accumulation of fluid in the peritoneal cavity.

Hematocrit

Percentage of red blood cells to whole blood, used to measure dehydration.

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Majority of body water location

The intracellular fluid compartment

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Conditions that lower oncotic pressure

Nephrotic syndrome or liver cirrhosis

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Veins to monitor fluid excess

Jugular veins

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Edema in pregnant women cause

Compression of the inferior vena cava by the growing uterus.

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Hangover causes

Dehydration, electrolyte imbalance, and accumulation of toxic byproducts like acetaldehyde from alcohol metabolism.

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Catabolism

Process of breaking down molecules

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Systems for metabolism

Endocrine and nervous system.

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Confirmatory test for HIV

Western Blot or HIV-1/HIV-2 differentiation immunoassay

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Enzyme produced by HIV

Reverse transcriptase

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Common HIV skin tumor

Kaposi sarcoma

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Advanced HIV CD4 count

<200 MM3

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Post-splenectomy infection

S. Pneumoniae

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HIV transmission modes

Blood transfusion, sexual contact, birth

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Opportunistic infections with HIV

PCP, TB, Candidiasis

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Immune cell destroyed

Helper T cells

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HAART

Highly active antiretroviral therapy.

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Study Notes

  • ANP helps to balance fluid by:

    • Promoting sodium excretion via the kidneys,
    • Increasing urine output
    • Inhibiting the renin-angiotensin-aldosterone system to lower blood volume and pressure
  • Approximately 300 ml of fluid is lost daily through the lungs.

  • Elephantiasis is caused by filarial worms obstructing the lymphatic vessels, leading to edema.

  • Ascites is the medical term for fluid accumulation in the peritoneal cavity.

  • In fluid excess, sodium concentration decreases due to water dilution.

  • Hematocrit measures the percentage of red blood cells in the whole blood and indicates dehydration.

  • Angiotensin II is not a vasodilator, therefore does not lower blood pressure.

  • The kidneys lose 1.5L of fluid daily.

  • The majority of water in the body is found in the intracellular fluid (ICF) compartment.

  • Nephrotic syndrome and liver cirrhosis are two diseases that can lower oncotic pressure.

  • Plasma oncotic pressure must be lower than capillary hydrostatic pressure for filtration to occur.

  • Jugular veins are typically used to monitor fluid excess.

  • Edema in late-term pregnant women is due to compression of the inferior vena cava by the growing uterus.

  • Hangovers are caused by:

    • Dehydration
    • Electrolyte imbalance
    • Accumulation of toxic byproducts like acetaldehyde from alcohol metabolism
  • Catabolism consists of molecules such as fats breaking down into fatty acids & glycerol, or proteins breaking down into amino acids.

  • The endocrine and nervous systems work together for proper metabolism.

  • Western Blot or HIV-1/HIV-2 differentiation immunoassay are confirmatory tests for HIV.

  • Reverse transcriptase is the enzyme produced by HIV to convert RNA into DNA.

  • Kaposi sarcoma is a skin tumor commonly seen in HIV patients.

  • A normal CD4 count is 600-1200 ML

  • CD4 counts <200 MM3 indicates advanced HIV.

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