Fluid and Electrolyte Homeostasis Quiz

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Questions and Answers

What is the primary consequence of albumin escaping the capillary wall?

  • Hypoproteinemia leading to decreased osmotic pressure (correct)
  • Increased lymphatic drainage
  • Increased reabsorption of fluids
  • Decreased hydrostatic pressure

What is a primary role of sodium in the extracellular fluid (ECF)?

  • Maintaining fluid balance and action potentials (correct)
  • Balancing anions between fluid compartments
  • Facilitating CO2 transport in blood
  • Neurotransmitter release

Which condition could lead to hypernatremia?

  • Reduced calcium levels
  • Decreased sodium output
  • Excessive fluid intake
  • Dehydration or increased sodium intake (correct)

How does lymphatic obstruction affect interstitial fluid?

<p>It leads to an excess accumulation of fluids in the interstitial space. (B)</p> Signup and view all the answers

Which electrolyte is most abundant in intracellular fluid (ICF)?

<p>Potassium (D)</p> Signup and view all the answers

What is the primary role of albumin in the process of reabsorption?

<p>It creates a concentration gradient that draws fluid back into the bloodstream. (D)</p> Signup and view all the answers

Which statement accurately describes filtration in the capillaries?

<p>Blood hydrostatic pressure pumps fluids, solutes, and albumin out of the capillaries. (B)</p> Signup and view all the answers

How do lymphatic capillaries contribute to fluid balance in the body?

<p>They absorb excess fluid left behind in the interstitial space and return it to circulation. (A)</p> Signup and view all the answers

What is the main difference between active and passive transport of fluids?

<p>Active transport requires ATP while passive transport does not. (C)</p> Signup and view all the answers

What triggers the movement of water into a cell during active transport?

<p>The expulsion of potassium ions and the subsequent influx of sodium ions. (D)</p> Signup and view all the answers

What triggers the production of atrial natriuretic peptide (ANP)?

<p>Abnormal increase in blood pressure/volume (D)</p> Signup and view all the answers

What is the primary effect of atrial natriuretic peptide (ANP) on the kidneys?

<p>Inhibits the release of renin (A)</p> Signup and view all the answers

Which of the following best describes edema?

<p>Abnormal fluid accumulation in interstitial space (A)</p> Signup and view all the answers

Which condition can lead to hypoproteinemia?

<p>Low protein levels in the blood (A)</p> Signup and view all the answers

What is the main cause of pleural effusion?

<p>Fluid accumulation in the thoracic cavity (B)</p> Signup and view all the answers

How does inflammation contribute to edema?

<p>Increases filtration through more permeable capillary walls (B)</p> Signup and view all the answers

What happens when venous pressure increases in capillaries?

<p>More fluid is filtered out, leading to edema (B)</p> Signup and view all the answers

What is a common consequence of hypoproteinemia?

<p>Inability to draw fluid back into capillaries (C)</p> Signup and view all the answers

What is the primary function of electrolytes in the body?

<p>To regulate osmosis, maintain acid-base balance, and carry electric current (A)</p> Signup and view all the answers

Which of the following correctly describes the distribution of body fluids?

<p>45% of women's body composition is liquids (C)</p> Signup and view all the answers

What is the role of non-electrolytes in the body?

<p>To remain undissociated and serve mainly as organic compounds (C)</p> Signup and view all the answers

According to Sterling's Law of the Capillary, what is the direction of fluid movement?

<p>From intravascular fluid to interstitial fluid, and then to intracellular fluid (C)</p> Signup and view all the answers

Which statement about intracellular fluid (ICF) composition is correct?

<p>It has low sodium and high potassium concentrations (A)</p> Signup and view all the answers

Which of these correctly characterizes interstitial fluid?

<p>It features high concentrations of sodium and bicarbonate (A)</p> Signup and view all the answers

What happens to the body if fluids and electrolytes are not properly balanced?

<p>The body's cells can undergo cellular death (A)</p> Signup and view all the answers

What proportion of extracellular fluid (ECF) is typically blood plasma?

<p>20% (B)</p> Signup and view all the answers

What primarily regulates the gain of water in the body?

<p>Fluid Intake Regulation (A)</p> Signup and view all the answers

What triggers the thirst mechanism in the body?

<p>Decreased blood volume (B)</p> Signup and view all the answers

Which hormone is released when dehydration occurs?

<p>ADH (A)</p> Signup and view all the answers

What is the effect of aldosterone on the kidneys?

<p>Increases water absorption (D)</p> Signup and view all the answers

What is the role of the RAAS system in fluid balance?

<p>Promotes sodium retention (C)</p> Signup and view all the answers

How does facilitated diffusion differ from osmosis?

<p>Facilitated diffusion relies on carrier/channel proteins. (A)</p> Signup and view all the answers

What characterizes diffusion in the context of cell membrane transport?

<p>Nutrients and gases move along the concentration gradient. (B)</p> Signup and view all the answers

Which factor primarily influences fluid output regulation?

<p>ANP Hormone (B)</p> Signup and view all the answers

Which condition is characterized by excessive sodium loss and muscle weakness?

<p>Hyponatremia (B)</p> Signup and view all the answers

What can excessive potassium levels in the body lead to?

<p>Cardiac arrest (D)</p> Signup and view all the answers

Which condition is least likely to cause increased levels of parathyroid hormone (PTH)?

<p>Hypokalemia (D)</p> Signup and view all the answers

Hypocalcemia can lead to which of the following symptoms?

<p>Muscle spasms (D)</p> Signup and view all the answers

Which electrolyte imbalance is characterized by excessive thirst and frequent urination?

<p>Hypercalcemia (D)</p> Signup and view all the answers

What is a common symptom of hyperchloremia?

<p>Hypertension (C)</p> Signup and view all the answers

Excessive intake of which vitamin can lead to hypercalcemia?

<p>Vitamin D (A)</p> Signup and view all the answers

Which condition is characterized by low levels of chloride in the body?

<p>Hypochloremia (B)</p> Signup and view all the answers

What symptom might indicate hyperkalemia?

<p>Shallow respiration (D)</p> Signup and view all the answers

Increased chloride levels can lead to which of the following conditions?

<p>Metabolic acidosis (A)</p> Signup and view all the answers

Flashcards

Fluid

Water and dissolved substances in the body's fluid compartments.

Electrolyte

Substances that form ions in water, crucial for fluid balance & functions.

Intracellular Fluid (ICF)

Fluid inside cells.

Interstitial Fluid

Fluid surrounding cells.

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Intravascular Fluid

Fluid inside blood vessels.

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Fluid Compartment Ratio (Men)

Men have 60% fluid; 40% solid.

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Sterling's Law

Describes fluid movement between blood and interstitial fluid.

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Electrolyte Composition (Intracellular)

High potassium & protein, low sodium & chloride.

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Filtration in Capillaries

The process where blood pressure forces fluids, solutes, and albumin out of the arteriole end of capillaries through the semi-permeable membrane. Only water and small particles can pass through, leaving albumin behind.

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Reabsorption in Capillaries

The process where the albumin remaining in the capillary generates osmotic pressure, drawing fluid back into the bloodstream due to the concentration gradient. Eventually, the concentration evens out, and reabsorption slows down.

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Lymphatic Capillaries

These capillaries collect excess fluid left behind in the interstitial space after reabsorption and return it to the bloodstream.

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Active Transport

Movement of molecules and fluids across cell membranes using protein carriers, pumps, and channels. This process requires energy (ATP).

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Passive Transport

Movement of molecules and fluids across cell membranes following the concentration gradient. This process does not require energy (ATP).

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Osmosis

The movement of water molecules across a semi-permeable membrane from an area of high water concentration to an area of low water concentration, to equalize the concentration on both sides.

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Facilitated Diffusion

The movement of larger molecules across a cell membrane with the help of carrier or channel proteins, along the concentration gradient, without requiring energy.

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Diffusion

The movement of small molecules, such as nutrients, gases, and waste products, across a cell membrane from an area of high concentration to an area of low concentration, to equalize the concentration.

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Fluid Balance

The state where the amount of water gained by the body is equal to the amount of water lost, ensuring proper hydration and cell function.

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Water Gain & Loss

Water is gained through ingestion (drinking), and lost through urine, feces, sweat, and breathing.

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Thirst Mechanism

A physiological response triggered by dehydration, involving a decrease in saliva production, increased blood osmolarity, and decreased blood volume, prompting us to drink water to restore balance.

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RAAS

A hormonal system that regulates blood pressure and fluid balance by increasing blood volume. It involves renin, angiotensinogen, angiotensin I and II, and aldosterone.

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ADH Hormone

A hormone released by the hypothalamus in response to dehydration, promoting water retention by the kidneys. It helps to conserve water and increase blood volume.

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Hypoproteinemia

A condition where there's a low level of protein in the blood, specifically albumin. This can occur when albumin leaks out of capillaries due to damage or inflammation. It leads to a decrease in osmotic pressure.

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Lymphatic Obstruction

A blockage in the lymphatic system, which prevents excess fluid from being drained from the interstitial space. This leads to fluid buildup in the tissues, causing swelling.

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Sodium's Importance

Sodium is the main cation in the extracellular fluid (ECF). Key roles include action potentials (nerve impulses) and water reabsorption.

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Potassium's Importance

Potassium is the dominant cation in the intracellular fluid (ICF). It's essential for action potentials, but also plays a vital role in water balance within cells.

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Hypernatremia

A condition with elevated levels of sodium in the blood. This occurs from decreased water intake, excess sodium intake, or inadequate sodium excretion.

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Renin Release Inhibition

ANP directly inhibits the release of renin from the kidneys, preventing the activation of the RAAS (Renin-Angiotensin-Aldosterone System), which normally increases blood pressure and volume.

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Edema

Abnormal fluid accumulation in the interstitial space (the space between cells), causing swelling.

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Causes of Edema

Edema can arise from four disruptions of Sterling's Law, which governs fluid movement between blood and interstitial space: increased venous pressure, decreased plasma protein levels (hypoproteinemia), inflammation and lymphatic obstruction.

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Venous Pressure

Compression of venules increases pressure within the capillaries, forcing more fluid out and causing fluid accumulation in the interstitial space.

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Inflammation

Inflammation makes the capillary walls more permeable, allowing more fluid to escape into the interstitial space, resulting in edema.

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Hypokalemia

Low potassium levels in the blood, caused by excessive loss, such as from vomiting, diarrhea, diuretics, or nasogastric suction.

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Hypocalcemia

Low calcium levels in the blood, caused by removal of PTH glands, vitamin D deficiency, or decreased intake of calcium.

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What causes increased PTH?

Increased levels of PTH (parathyroid hormone) can be caused by tumors, Paget's disease, or conditions that lead to low blood calcium levels.

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Hyperchloremia

High chloride levels in the blood, caused by excessive intake, dehydration, severe renal failure, or hyperaldosteronism.

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Hypochloremia

Low chloride levels in the blood, caused by excessive loss, such as from vomiting, overhydration, metabolic alkalosis, or aldosterone deficiency.

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What are the symptoms of hyponatremia?

Hyponatremia is low sodium levels in the blood. Symptoms include muscle weakness, fatigue, nausea, vomiting, and confusion.

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What are the symptoms of hypernatremia?

Hypernatremia is high sodium levels in the blood. Symptoms include thirst, confusion, seizures, and coma.

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What is the function of aldosterone?

Aldosterone is a hormone that regulates electrolyte balance and fluid volume. It promotes sodium retention and potassium excretion.

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Study Notes

Fluid and Electrolyte Definition

  • Fluids: Water and dissolved substances within the body's compartments
  • Electrolytes: Substances that dissociate in water into ions, controlling osmosis, maintaining acid-base balance, and carrying electric current necessary for enzyme activities.
  • Non-electrolytes: Substances that don't dissociate, aren't electrically charged, and are mainly organic compounds (lipids, glucose, urea, creatinine).
  • Homeostasis of cells depends on balanced fluids and electrolytes regulating volume, distribution, solute concentrations, and pH.

Body's Fluid Compartments

  • ICF (Intracellular Fluid): Fluid within cells (cytoplasm)
  • ECF (Extracellular Fluid):
    • Interstitial fluid: Fluid surrounding cells and blood vessels.
    • Intravascular fluid: Fluid within arteries and veins (blood plasma)

Body Fluid Distribution

  • Women: 45% solids, 55% liquids
  • Men: 40% solids, 60% liquids
  • 2/3 of body fluids are intracellular
  • 1/3 of body fluids are extracellular (80% interstitial, 20% blood plasma)

Composition of Body Fluids

Compartment Na+ HCO3- HPO42- Protein Potassium Cl-
Intracellular Low None High High Low High
Interstitial High High None None Low High
Intravascular High High None High Low High

Movement of Fluid: Intravascular → Interstitial

  • Filtration: Blood hydrostatic pressure pushes fluids, solutes, and albumin out of capillaries at the arteriole end.
  • Reabsorption: Albumin in the interstitial space creates osmotic pressure, drawing fluid back into the bloodstream.
  • Lymphatic Capillaries: Excess interstitial fluid is absorbed by lymphatic capillaries and returned to blood.

Movement of Fluid: Interstitial → Intracellular

  • Active Transport: Protein carriers move ions across cell membranes using ATP (energy).
  • Passive Transport:
    • Osmosis: Water moves across membranes based on concentration gradients
    • Facilitated Diffusion: Larger molecules use carrier proteins to move across membranes
    • Diffusion: Nutrients, gases, and wastes move across based on concentration gradients
  • The regulation of fluid balance between compartments is essential.

Fluid Balance

  • Water gain and loss must be equal.
  • Major sources of water gain are ingestion.
  • Loss occurs through urine, feces, sweat, and breath.
  • Fluid intake is regulated by thirst mechanism, RAAS, and ADH.
  • Fluid output is regulated by ANP.

Thirst Mechanism

  • Thirst center in hypothalamus triggered by decreased saliva production, increased blood osmolarity, or decreased blood volume.
  • Thirst helps restore body water levels.

RAAS (Renin-Angiotensin-Aldosterone System)

  • A series of chemical reactions that causes kidneys to reabsorb sodium and water, leading to increased blood volume.

ADH (Antidiuretic Hormone)

  • Released by the hypothalamus in response to dehydration, triggering the kidneys to retain water and reduce urine output, increasing blood volume.

Fluid Imbalances

  • Edema: Abnormal fluid accumulation in interstitial space due to venous pressure, hypoproteinemia, inflammation, or lymphatic obstruction.
  • Effusion: Fluid accumulation in body cavities (pleural, peritoneal, or pericardial).

Electrolyte Imbalances (Examples)

  • Hypernatremia: High sodium; symptoms include thirst, dry mouth, decreased urine output.
  • Hyponatremia: Low sodium; symptoms include nausea, confusion, and abdominal cramps.
  • Hyperkalemia and Hypokalemia: High and Low potassium, respectively
  • Hypercalcemia, Hypocalcemia, Hyperchloremia and Hypochloremia: High and Low calcium, chloride, respectively .
  • These imbalances can lead to various health problems, and accurate diagnosis and treatment are crucial.

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