24 Questions
What type of drum is typically used in the film coating process with Perforated Pan Systems?
Perforated drum
Which system allows the drying air to be directed from inside the drum through the tablet bed?
Driacoater
How is the coating system applied to the tablets in Pan coating process?
Through spraying nozzles or distribution pipes
What is the first step in the Pan coating process?
Charging the pan with tablets
When should half of the coating solution be applied in Pan coating?
When the tablets begin to tumble
In the Pan coating process, when should the rest of the solution be added?
At interval of 5 - 10 min
What is a potential solution to film cracking issues?
Adjusting plasticizer type or concentration
What can result in an 'orange peel' effect on a coating?
Inadequate spreading of the coating solution
How can bridging of logos on a coating be decreased?
Increasing the plasticizer content
What is a common cause of blistering in coatings?
Too slow evaporation of solvent
How is sugar coating different from film coating?
Sugar coating is quicker than film coating
What change can decrease color variation issues in coatings?
Improving mixing and spray pattern uniformity
Which process variables are crucial in the film coating process?
All of the above
What are the two basic systems used to apply a finely divided spray onto tablets?
Low pressure air atomized and high pressure airless
Which coating fault is caused by overwetting and inadequate drying conditions?
Picking and twining
What may occur if the internal stresses exceed the tensile strength of the film in film-coated tablets?
Cracking
Which characteristic should film-coated tablets ideally display according to the text?
Distinctness of logos and break lines
What is the main purpose of the film coating process as mentioned in the text?
To provide an even coverage of film and color
What is the purpose of applying a seal coat to the tablet core in sugar coating?
To prevent moisture penetration
Which material is a purified resinous secretion of the insect Laccifer lacca used in sugar coating?
Shellac
What is one of the stability problems associated with Shellac used in sugar coating?
Increased disintegration and dissolution times on storage
Which technique can be used to apply the coating syrup in sugar coating?
Manually using a ladle
What are some materials that can be used for sealing in sugar-coating techniques?
Zein and cellulose acetate phthalate
What is a possible method for preventing localized overwetting in sugar coating?
Adjusting the application of subcoats and coat in spray processes
Test your knowledge on common film coating defects and the methods to overcome them. Topics include cracking, peeling, blistering, bridging, and other coating faults. Learn about improving mechanical properties of films with higher molecular weight polymers or adjusting plasticizer type/concentration.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
