16 Questions
What is the characteristic feature of the structure of fibril-forming collagen?
Elongated, triple-helical structure stabilized by interchain hydrogen bonds
What is responsible for the 'kinks' in the peptide chain of collagen?
Proline residues
What is the function of hydroxyproline and hydroxylysine in collagen?
To stabilize the triple helical structure
What is the site of glycosylation in collagen?
The hydroxyl group of hydroxylysine residues
Which of the following tissues is characterized by the presence of fibril-associated collagen?
All of the above
What is the first step in the biosynthesis of collagen?
The transcription of genes into mRNAs
What is the first step in the synthesis of collagen?
Translation of mRNA on the RER
What is the role of procollagen peptidases in collagen synthesis?
To cleave the N- and C-terminal propeptides
What is the characteristic feature of Ehlers-Danlos syndrome?
Skin extensibility and joint hypermobility
What is the function of alpha-1 antitrypsin (AAT)?
To inhibit elastase in the lungs
What is the consequence of a deficiency in lysyl hydroxylase?
Impaired collagen synthesis
What type of collagen is commonly associated with osteogenesis imperfecta?
Type I
What is the consequence of a mutation in the fibrillin-1 protein?
Marfan syndrome
What is the function of vitamin C in collagen synthesis?
Hydroxylation of proline and lysine residues
What is the characteristic feature of scurvy?
Collagen with decreased tensile strength
What is the structure of elastin?
An insoluble protein polymer
This quiz covers the structure and functions of fibrous proteins, the most abundant protein in the human body. Learn about their rigid structure, types, and distribution in different tissues and organs.
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