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Fibrous Proteins in Human Body

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Questions and Answers

What is the characteristic feature of the structure of fibril-forming collagen?

Elongated, triple-helical structure stabilized by interchain hydrogen bonds (correct)

Globular structure with a hydrophobic core

Ropelike structure with a beta-pleated sheet

Pleated structure with a charged surface

What is responsible for the 'kinks' in the peptide chain of collagen?

Hydroxyproline residues

Hydroxylysine residues

Glycine residues

Proline residues (correct)

What is the function of hydroxyproline and hydroxylysine in collagen?

To provide a charged surface

To stabilize the triple helical structure (correct)

To increase the tensile strength of collagen

To facilitate the formation of disulfide bonds

What is the site of glycosylation in collagen?

The hydroxyl group of hydroxylysine residues Signup and view all the answers

Which of the following tissues is characterized by the presence of fibril-associated collagen?

All of the above Signup and view all the answers

What is the first step in the biosynthesis of collagen?

The transcription of genes into mRNAs Signup and view all the answers

What is the first step in the synthesis of collagen?

Translation of mRNA on the RER Signup and view all the answers

What is the role of procollagen peptidases in collagen synthesis?

To cleave the N- and C-terminal propeptides Signup and view all the answers

What is the characteristic feature of Ehlers-Danlos syndrome?

Skin extensibility and joint hypermobility Signup and view all the answers

What is the function of alpha-1 antitrypsin (AAT)?

To inhibit elastase in the lungs Signup and view all the answers

What is the consequence of a deficiency in lysyl hydroxylase?

Impaired collagen synthesis Signup and view all the answers

What type of collagen is commonly associated with osteogenesis imperfecta?

Type I Signup and view all the answers

What is the consequence of a mutation in the fibrillin-1 protein?

Marfan syndrome Signup and view all the answers

What is the function of vitamin C in collagen synthesis?

Hydroxylation of proline and lysine residues Signup and view all the answers

What is the characteristic feature of scurvy?

Collagen with decreased tensile strength Signup and view all the answers

What is the structure of elastin?

An insoluble protein polymer Signup and view all the answers