Fibrous Proteins: Structure and Types

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Questions and Answers

What is the primary function of the fibril-associated collagens?

To provide tensile strength to skin
To form a ropelike structure
To link collagen fibrils together (correct)
To form a meshwork structure

What is the role of hydroxylation in collagen synthesis?

To modify lysine and proline residues after incorporation into polypeptide chains (correct)
To facilitate the formation of alpha helices
To inhibit the formation of collagen fibers
To increase the tensile strength of collagen

What is the function of glycine in the collagen triple helix?

To provide flexibility to the collagen fiber
To stabilize the triple helix through hydrogen bonding
To inhibit the formation of alpha helices
To facilitate the formation of kinks in the peptide chain (correct)

What is the characteristic structure of collagen?

Elongated, triple-helical structure (A) Signup and view all the answers

What is the role of proline in the collagen triple helix?

To cause kinks in the peptide chain, facilitating the formation of the triple helix (B) Signup and view all the answers

What is the first step in the biosynthesis of collagen?

Transcription of genes of pro-alpha 1 and pro-alpha 2 chains (B) Signup and view all the answers

What is the function of lysyl hydroxylase in collagen production?

To hydroxylate selected proline and lysine residues (D) Signup and view all the answers

What is the characteristics of type 1 osteogenesis imperfecta (OI)?

Characterized by mild bone fragility, hearing loss, and blue sclera (D) Signup and view all the answers

What is the role of vitamin C in collagen production?

To hydroxylate proline and lysine residues (A) Signup and view all the answers

What is the difference between elastin and collagen?

Elastin is rich in glycine, alanine, valine, proline, and lysine, while collagen is rich in hydroxylysine and hydroxyproline (A) Signup and view all the answers