Fibroblast Essentials

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Questions and Answers

What is the principal function of fibroblasts in connective tissue?

  • Produce and maintain most of the tissue’s extracellular components (correct)
  • Act as immune cells in the dermis
  • Produce and release neurotransmitters
  • Transport oxygen to the surrounding cells

What is the characteristic morphology of fibroblasts?

  • Spindle-shaped with large active nuclei and eosinophilic cytoplasm (correct)
  • Irregular-shaped with elongated nuclei and acidophilic cytoplasm
  • Star-shaped with multiple dendritic processes
  • Round with small nuclei and basophilic cytoplasm

How can active and quiescent fibroblasts be distinguished?

  • Quiescent fibroblasts have large, euchromatic nuclei and acidophilic cytoplasm
  • Active fibroblasts have large, euchromatic nuclei and basophilic cytoplasm (correct)
  • Active fibroblasts have small, heterochromatic nuclei and acidophilic cytoplasm
  • Quiescent fibroblasts have small, heterochromatic nuclei and basophilic cytoplasm

What makes it difficult to distinguish the eosinophilic cytoplasmic processes of fibroblasts in H&E-stained sections?

<p>They resemble the collagen bundles that fill the ECM (B)</p> Signup and view all the answers

What is the main function of fibrocytes in the dermis?

<p>Inactive fibroblasts involved in maintaining the ECM (A)</p> Signup and view all the answers

What is the role of major histocompatibility complex II (MHC II) molecules on the surface of macrophages?

<p>Interact with helper CD4+ T lymphocytes (C)</p> Signup and view all the answers

What happens when macrophages engulf a foreign cell?

<p>Antigens from the foreign cell are displayed on the surface of MHC II molecules (D)</p> Signup and view all the answers

What is the function of macrophages in the immune response?

<p>Present antigens to helper CD4+ T lymphocytes (B)</p> Signup and view all the answers

What is the transformation process of monocytes into macrophages characterized by?

<p>Increases in cell size and protein synthesis (A)</p> Signup and view all the answers

What is the family of cells called that macrophages are a part of?

<p>Mononuclear phagocyte system (B)</p> Signup and view all the answers

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