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Fibroblast Essentials

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Questions and Answers

What is the principal function of fibroblasts in connective tissue?

Produce and maintain most of the tissue’s extracellular components (correct)

Act as immune cells in the dermis

Produce and release neurotransmitters

Transport oxygen to the surrounding cells

What is the characteristic morphology of fibroblasts?

Spindle-shaped with large active nuclei and eosinophilic cytoplasm (correct)

Irregular-shaped with elongated nuclei and acidophilic cytoplasm

Star-shaped with multiple dendritic processes

Round with small nuclei and basophilic cytoplasm

How can active and quiescent fibroblasts be distinguished?

Quiescent fibroblasts have large, euchromatic nuclei and acidophilic cytoplasm

Active fibroblasts have large, euchromatic nuclei and basophilic cytoplasm (correct)

Active fibroblasts have small, heterochromatic nuclei and acidophilic cytoplasm

Quiescent fibroblasts have small, heterochromatic nuclei and basophilic cytoplasm

What makes it difficult to distinguish the eosinophilic cytoplasmic processes of fibroblasts in H&E-stained sections?

They resemble the collagen bundles that fill the ECM Signup and view all the answers

What is the main function of fibrocytes in the dermis?

Inactive fibroblasts involved in maintaining the ECM Signup and view all the answers

What is the role of major histocompatibility complex II (MHC II) molecules on the surface of macrophages?

Interact with helper CD4+ T lymphocytes Signup and view all the answers

What happens when macrophages engulf a foreign cell?

Antigens from the foreign cell are displayed on the surface of MHC II molecules Signup and view all the answers

What is the function of macrophages in the immune response?

Present antigens to helper CD4+ T lymphocytes Signup and view all the answers

What is the transformation process of monocytes into macrophages characterized by?

Increases in cell size and protein synthesis Signup and view all the answers

What is the family of cells called that macrophages are a part of?

Mononuclear phagocyte system Signup and view all the answers