Hemodynamics II
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Questions and Answers

Which of the following is NOT a component of normal hemostasis?

  • Platelets
  • Counter-regulation (correct)
  • Coagulation cascade
  • Vascular wall

    • What is the primary function of endothelial cells in a healthy blood vessel?

  • Promotion of coagulation cascade
  • Promotion of platelet adherence
  • Inhibition of platelets (correct)
  • Inhibition of coagulation

    • What are the causes of pathological thrombosis?

  • Endothelial injury
  • Abnormal flow
  • Hypercoagulability of blood
  • All of the above (correct)

    • Which type of thrombus forms in the heart?

    <p>Cardiac (mural) thrombus</p> Signup and view all the answers

    What are the 4 steps in the formation and regulation of the permanent hemostatic plug?

    <p>Local response, primary hemostatic plug, secondary hemostatic plug, counter-regulation</p> Signup and view all the answers

    Which of the following factors is responsible for the activation of Factor X in the extrinsic pathway of the coagulation cascade?

    <p>Factor VII</p> Signup and view all the answers

    Which of the following factors is responsible for the activation of Factor IX in the intrinsic pathway of the coagulation cascade?

    <p>Factor XI</p> Signup and view all the answers

    Which of the following factors is responsible for the activation of Factor X in the intrinsic pathway of the coagulation cascade?

    <p>Factor IX</p> Signup and view all the answers

    Which of the following factors is responsible for the conversion of prothrombin to active thrombin in the common pathway of the coagulation cascade?

    <p>Factor V</p> Signup and view all the answers

    Which of the following factors is responsible for the conversion of fibrinogen to fibrin in the final clot formation?

    <p>Factor XIII</p> Signup and view all the answers

    Which of the following is the main cause of arterial thrombus formation?

    <p>Endothelial damage</p> Signup and view all the answers

    Which of the following is NOT a characteristic of venous thrombi?

    <p>Elongation in the direction of blood flow</p> Signup and view all the answers

    What is the fate of a thrombus?

    <p>Propagation, fibrinolytic resolution, embolization, organization</p> Signup and view all the answers

    What is the main cause of disseminated intravascular coagulation (DIC)?

    <p>All of the above</p> Signup and view all the answers

    What is the consequence of disseminated intravascular coagulation (DIC)?

    <p>Uncontrolled bleeding disorder</p> Signup and view all the answers

    Which of the following is NOT one of the causes of pathological thrombosis according to the Virchow triad?

    <p>Increased platelet count</p> Signup and view all the answers

    What is the characteristic of a mural thrombus in the heart?

    <p>Lines of Zahn</p> Signup and view all the answers

    Which genetic defect causes resistance to inhibition by Protein C?

    <p>Factor V mutation</p> Signup and view all the answers

    Which of the following is an acquired cause of hypercoagulability?

    <p>Heparin-induced thrombocytopenia syndrome</p> Signup and view all the answers

    What is the role of tissue factor pathway inhibitor (TFPI) in hemostasis?

    <p>Inhibits the factor X and VII complex</p> Signup and view all the answers

    Which of the following is NOT a component of normal hemostasis?

    <p>Fibrinolysis</p> Signup and view all the answers

    Which step in the hemostatic response to vascular injury involves the activation of the coagulation cascade?

    <p>Formation of secondary hemostatic plug</p> Signup and view all the answers

    What is the role of thrombin in the formation of the secondary hemostatic plug?

    <p>Thrombin cleaves fibrinogen to insoluble fibrin</p> Signup and view all the answers

    What is the purpose of counterregulatory measures in the hemostatic process?

    <p>To prevent thrombus formation</p> Signup and view all the answers

    What is the role of endothelial cells in hemostasis in a normal cell?

    <p>To inhibit coagulation</p> Signup and view all the answers

    Which of the following is NOT a way in which endothelial cells inhibit thrombus formation in a normal vessel?

    <p>Binding anti-thrombin III</p> Signup and view all the answers

    Which of the following is NOT a function of endothelial cells in inhibiting coagulation?

    <p>Activating Protein C</p> Signup and view all the answers

    Which of the following is NOT a pro-thrombotic activity of endothelial cells in a damaged vessel?

    <p>Secreting inhibitors of tPA</p> Signup and view all the answers

    Which of the following is NOT contained in platelet α granules?

    <p>Serotonin</p> Signup and view all the answers

    Which of the following is NOT a step in plug formation after platelet adhesion?

    <p>Endothelial PGI-2 inhibition</p> Signup and view all the answers

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