Hemodynamics II

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Questions and Answers

Which of the following is NOT a component of normal hemostasis?

  • Platelets
  • Counter-regulation (correct)
  • Coagulation cascade
  • Vascular wall

What is the primary function of endothelial cells in a healthy blood vessel?

  • Promotion of coagulation cascade
  • Promotion of platelet adherence
  • Inhibition of platelets (correct)
  • Inhibition of coagulation

What are the causes of pathological thrombosis?

  • Endothelial injury
  • Abnormal flow
  • Hypercoagulability of blood
  • All of the above (correct)

Which type of thrombus forms in the heart?

<p>Cardiac (mural) thrombus (A)</p> Signup and view all the answers

What are the 4 steps in the formation and regulation of the permanent hemostatic plug?

<p>Local response, primary hemostatic plug, secondary hemostatic plug, counter-regulation (C)</p> Signup and view all the answers

Which of the following factors is responsible for the activation of Factor X in the extrinsic pathway of the coagulation cascade?

<p>Factor VII (B)</p> Signup and view all the answers

Which of the following factors is responsible for the activation of Factor IX in the intrinsic pathway of the coagulation cascade?

<p>Factor XI (C)</p> Signup and view all the answers

Which of the following factors is responsible for the activation of Factor X in the intrinsic pathway of the coagulation cascade?

<p>Factor IX (B)</p> Signup and view all the answers

Which of the following factors is responsible for the conversion of prothrombin to active thrombin in the common pathway of the coagulation cascade?

<p>Factor V (A)</p> Signup and view all the answers

Which of the following factors is responsible for the conversion of fibrinogen to fibrin in the final clot formation?

<p>Factor XIII (C)</p> Signup and view all the answers

Which of the following is the main cause of arterial thrombus formation?

<p>Endothelial damage (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of venous thrombi?

<p>Elongation in the direction of blood flow (D)</p> Signup and view all the answers

What is the fate of a thrombus?

<p>Propagation, fibrinolytic resolution, embolization, organization (C)</p> Signup and view all the answers

What is the main cause of disseminated intravascular coagulation (DIC)?

<p>All of the above (D)</p> Signup and view all the answers

What is the consequence of disseminated intravascular coagulation (DIC)?

<p>Uncontrolled bleeding disorder (A)</p> Signup and view all the answers

Which of the following is NOT one of the causes of pathological thrombosis according to the Virchow triad?

<p>Increased platelet count (B)</p> Signup and view all the answers

What is the characteristic of a mural thrombus in the heart?

<p>Lines of Zahn (D)</p> Signup and view all the answers

Which genetic defect causes resistance to inhibition by Protein C?

<p>Factor V mutation (D)</p> Signup and view all the answers

Which of the following is an acquired cause of hypercoagulability?

<p>Heparin-induced thrombocytopenia syndrome (D)</p> Signup and view all the answers

What is the role of tissue factor pathway inhibitor (TFPI) in hemostasis?

<p>Inhibits the factor X and VII complex (D)</p> Signup and view all the answers

Which of the following is NOT a component of normal hemostasis?

<p>Fibrinolysis (D)</p> Signup and view all the answers

Which step in the hemostatic response to vascular injury involves the activation of the coagulation cascade?

<p>Formation of secondary hemostatic plug (D)</p> Signup and view all the answers

What is the role of thrombin in the formation of the secondary hemostatic plug?

<p>Thrombin cleaves fibrinogen to insoluble fibrin (D)</p> Signup and view all the answers

What is the purpose of counterregulatory measures in the hemostatic process?

<p>To prevent thrombus formation (A)</p> Signup and view all the answers

What is the role of endothelial cells in hemostasis in a normal cell?

<p>To inhibit coagulation (C)</p> Signup and view all the answers

Which of the following is NOT a way in which endothelial cells inhibit thrombus formation in a normal vessel?

<p>Binding anti-thrombin III (D)</p> Signup and view all the answers

Which of the following is NOT a function of endothelial cells in inhibiting coagulation?

<p>Activating Protein C (A)</p> Signup and view all the answers

Which of the following is NOT a pro-thrombotic activity of endothelial cells in a damaged vessel?

<p>Secreting inhibitors of tPA (C)</p> Signup and view all the answers

Which of the following is NOT contained in platelet α granules?

<p>Serotonin (B)</p> Signup and view all the answers

Which of the following is NOT a step in plug formation after platelet adhesion?

<p>Endothelial PGI-2 inhibition (D)</p> Signup and view all the answers

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Hemodynamics II Notes PDF

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