Female Sex Hormones and Their Physiological Functions
20 Questions
5 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which hormone is the principle estrogen in premenopausal women?

  • Estriol
  • Estrone
  • Estradiol (correct)
  • Ethinylestradiol

    • What is the primary circulating estrogen after menopause?

  • Estriol
  • Estradiol
  • Estrone (correct)
  • Mestranol

    • Which type of estrogen is significantly less potent than estradiol and is present in significant amounts during pregnancy?

  • Estrone
  • Quinesterol
  • Mestranol
  • Estriol (correct)

    • Which type of estrogen is synthetically produced, has long duration, and slow metabolism?

    <p>Synthetic Estrogen</p> Signup and view all the answers

    What is the main physiological function of estrogen related to the endometrium?

    <p>Stimulation of proliferative phase</p> Signup and view all the answers

    What is the mechanism of action of conjugated estrogens in target tissues?

    <p>Interaction with nuclear receptors Erα and Erβ in target tissues</p> Signup and view all the answers

    What is the therapeutic use of postmenopausal hormone therapy (HT) called estrogen-progesterone therapy (EPT)?

    <p>Prevention of menopausal symptoms and protection against osteoporosis</p> Signup and view all the answers

    How are naturally occurring estrogens and synthetic estrogen analogs primarily administered?

    <p>Orally</p> Signup and view all the answers

    What is the primary reason for the low bioavailability of orally administered estrogens?

    <p>Rapid metabolism and inactivation by the liver</p> Signup and view all the answers

    What is the recommended hormone therapy for women who have undergone surgical removal of the uterus?

    <p>Unopposed estrogen therapy</p> Signup and view all the answers

    Which of the following is NOT a physiological function of estrogen?

    <p>Development of male reproductive tract</p> Signup and view all the answers

    Which type of estrogen is the principle estrogen in premenopausal women?

    <p>Estradiol</p> Signup and view all the answers

    What is the primary circulating estrogen after menopause?

    <p>Estrone</p> Signup and view all the answers

    Which type of estrogen has long duration of action and slow metabolic rate?

    <p>Synthetic steroidal estrogen</p> Signup and view all the answers

    Which type of estrogen is significantly less potent than estradiol and is present in significant amounts during pregnancy?

    <p>Estriol</p> Signup and view all the answers

    What is the primary mechanism of action of estrogens in target tissues?

    <p>Stimulation of gene transcription</p> Signup and view all the answers

    What is the recommended hormone therapy for women who have undergone surgical removal of the uterus?

    <p>Unopposed estrogen therapy</p> Signup and view all the answers

    What is the main physiological function of conjugated estrogens in target tissues?

    <p>Reduction of menopausal symptoms</p> Signup and view all the answers

    Why is the bioavailability of orally administered estrogens low?

    <p>Rapid metabolism and partial inactivation by the liver</p> Signup and view all the answers

    What is the therapeutic use of postmenopausal Hormone Therapy (HT) called estrogen-progesterone therapy (EPT)?

    <p>Reducing osteoporosis risk after menopause</p> Signup and view all the answers

    Study Notes

    Estrogens Overview

    • Estradiol is the principal estrogen in premenopausal women, playing a key role in reproductive health.
    • After menopause, estrone becomes the primary circulating estrogen, replacing estradiol.

    Types of Estrogens

    • Estriol is significantly less potent than estradiol and is present in considerable amounts during pregnancy.
    • Ethinyl estradiol is a synthetic estrogen that has a long duration of action and slow metabolism, making it effective for various therapeutic uses.

    Physiological Functions

    • Estrogen primarily promotes the proliferation of the endometrium, preparing it for potential implantation of a fertilized egg.
    • The main physiological action of estrogens in target tissues involves binding to estrogen receptors, initiating transcription of estrogen-responsive genes.

    Hormone Therapy and Administration

    • Estrogen-progesterone therapy (EPT) is a common postmenopausal hormone therapy aimed at alleviating menopausal symptoms and preventing osteoporosis.
    • Estrogens, both naturally occurring and synthetic analogs, are primarily administered through oral routes, patches, or other delivery systems.

    Bioavailability and Additional Considerations

    • The low bioavailability of orally administered estrogens is mainly due to first-pass metabolism in the liver, which significantly reduces the amount that enters systemic circulation.
    • For women who have had a hysterectomy, estrogen-only therapy is recommended to mitigate menopausal symptoms without the need for additional progesterone.

    Summary of Estrogen Functions

    • Not all physiological functions of estrogen include ovulation induction; functions also encompass regulation of fat distribution, treatment of osteoporosis, and maintenance of reproductive tissues.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Pharmacology questions

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser