Feline Mammary Gland Disorders
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Questions and Answers

What is the known cause of mammary tumors in mice?

  • Nutrition
  • Oncornavirus (correct)
  • Hormones
  • Genetics
  • Which genes are significantly associated with mammary tumors in humans?

  • ER and PR
  • BRCA1 and BRCA2 (correct)
  • hGH and IGF-1
  • p53 and PTEN
  • How does obesity mediate breast cancer risk in postmenopausal women?

  • By inhibiting aromatase activity
  • By increasing circulating free testosterone levels
  • By increasing circulating free estrogen levels (correct)
  • By reducing local estrogen production
  • Which single nucleotide polymorphisms (SNPs) were found to be significantly associated with canine mammary tumors?

    <p>One SNP in exon 9 of BRCA1 and one SNP in exon 24 of BRCA2</p> Signup and view all the answers

    What treatment approach has been beneficial in treating inflammatory mammary carcinoma in dogs?

    <p>NSAID piroxicam</p> Signup and view all the answers

    Which factor is NOT mentioned as affecting the prognosis of mammary tumors in dogs?

    <p>Histologic diagnosis</p> Signup and view all the answers

    In cats, what is the median survival time for tumors >3 cm in diameter?

    <p>6 months</p> Signup and view all the answers

    What is the current dogma regarding reducing the lifetime risk for mammary neoplasia in dogs?

    <p>Prepubertal ovariectomy or ovariohysterectomy</p> Signup and view all the answers

    Which malignancy treatment approach is mentioned as having an antitumor effect in other malignancies?

    <p>Metronomic low-dose therapy</p> Signup and view all the answers

    What did a systematic review of the literature find regarding the association between age at spaying and the risk of mammary neoplasia?

    <p>'Age at spaying' has a weak association with risk</p> Signup and view all the answers

    Which species has the highest prevalence of mammary neoplasia?

    <p>Dogs</p> Signup and view all the answers

    What is the primary site of metastasis for mammary carcinomas in both dogs and cats?

    <p>Regional lymph nodes and lungs</p> Signup and view all the answers

    What is the approximate risk reduction of mammary neoplasia in intact bitches with ovariectomy before the first estrus?

    <p>95%</p> Signup and view all the answers

    In dogs, which glands are more often involved in mammary tumors?

    <p>Two posterior glands</p> Signup and view all the answers

    Which breed of dogs might have an increased overall cancer risk associated with early-age ovariectomy?

    <p>Golden Retrievers</p> Signup and view all the answers

    What type of mammary tumors are most common in cats?

    <p>Adenocarcinomas</p> Signup and view all the answers

    At what age do cats experience a significant reduction in the risk of mammary carcinoma development if spayed?

    <p>&lt; 6 months</p> Signup and view all the answers

    What is the primary site of metastasis for canine mammary tumors?

    <p>Regional lymph nodes and lungs</p> Signup and view all the answers

    Which tumor type may contain grossly recognizable bone or cartilage on the cut surface?

    <p>Mixed mammary tumors</p> Signup and view all the answers

    Which gland is more frequently involved in mammary tumors in cats compared to dogs?

    <p>Anterior glands</p> Signup and view all the answers

    In cats, which factor does not affect feline mammary carcinoma development?

    <p>Parity</p> Signup and view all the answers

    Which of the following is NOT a characteristic of feline mammary hypertrophy?

    <p>Commonly diagnosed through thoracic radiographs</p> Signup and view all the answers

    Why are fine-needle aspirates considered a good diagnostic option for mammary tumors in dogs and cats?

    <p>They are less invasive compared to histopathology</p> Signup and view all the answers

    What is the primary treatment option for mammary tumors in dogs and cats?

    <p>Lumpectomy</p> Signup and view all the answers

    Which characteristic is NOT typically associated with malignant mammary tumors?

    <p>Low nuclear-to-cytoplasmic ratio</p> Signup and view all the answers

    Why is there no consensus on the best surgical procedure for treating mammary tumors in dogs and cats?

    <p>The wide variation in tumor types and locations</p> Signup and view all the answers

    Which factor makes evaluating the response to adjuvant chemotherapy difficult for canine mammary tumors?

    <p>Half of the diagnosed malignant tumors do not behave as such</p> Signup and view all the answers

    What has been shown to potentiate G0/G1 arrest in cell cycle progression when used in conjunction with doxorubicin?

    <p>Deracoxib</p> Signup and view all the answers

    Which imaging technique has moderate sensitivity and specificity to predict malignancy in neoplastic mammary tissue?

    <p>Ultrasound elastography</p> Signup and view all the answers

    What is a distinguishing feature of feline mammary hypertrophy?

    <p>Rapid growth of one or more mammary glands</p> Signup and view all the answers

    What is the role of Robinson's grading system in fine-needle aspirates?

    <p>To evaluate cellular characteristics indicating malignancy</p> Signup and view all the answers

    What characteristic is NOT helpful in predicting malignancy using B-mode and Doppler ultrasonography?

    <p>Cellular pleomorphism</p> Signup and view all the answers

    Why is chemotherapy not considered an effective treatment for mammary tumors in dogs?

    <p>Chemotherapy has not shown survival benefits in dogs</p> Signup and view all the answers

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