Feline Mammary Gland Disorders
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Questions and Answers

What is the known cause of mammary tumors in mice?

  • Nutrition
  • Oncornavirus (correct)
  • Hormones
  • Genetics

Which genes are significantly associated with mammary tumors in humans?

  • ER and PR
  • BRCA1 and BRCA2 (correct)
  • hGH and IGF-1
  • p53 and PTEN

How does obesity mediate breast cancer risk in postmenopausal women?

  • By inhibiting aromatase activity
  • By increasing circulating free testosterone levels
  • By increasing circulating free estrogen levels (correct)
  • By reducing local estrogen production

Which single nucleotide polymorphisms (SNPs) were found to be significantly associated with canine mammary tumors?

<p>One SNP in exon 9 of BRCA1 and one SNP in exon 24 of BRCA2 (A)</p> Signup and view all the answers

What treatment approach has been beneficial in treating inflammatory mammary carcinoma in dogs?

<p>NSAID piroxicam (C)</p> Signup and view all the answers

Which factor is NOT mentioned as affecting the prognosis of mammary tumors in dogs?

<p>Histologic diagnosis (B)</p> Signup and view all the answers

In cats, what is the median survival time for tumors >3 cm in diameter?

<p>6 months (C)</p> Signup and view all the answers

What is the current dogma regarding reducing the lifetime risk for mammary neoplasia in dogs?

<p>Prepubertal ovariectomy or ovariohysterectomy (B)</p> Signup and view all the answers

Which malignancy treatment approach is mentioned as having an antitumor effect in other malignancies?

<p>Metronomic low-dose therapy (A)</p> Signup and view all the answers

What did a systematic review of the literature find regarding the association between age at spaying and the risk of mammary neoplasia?

<p>'Age at spaying' has a weak association with risk (A)</p> Signup and view all the answers

Which species has the highest prevalence of mammary neoplasia?

<p>Dogs (D)</p> Signup and view all the answers

What is the primary site of metastasis for mammary carcinomas in both dogs and cats?

<p>Regional lymph nodes and lungs (D)</p> Signup and view all the answers

What is the approximate risk reduction of mammary neoplasia in intact bitches with ovariectomy before the first estrus?

<p>95% (A)</p> Signup and view all the answers

In dogs, which glands are more often involved in mammary tumors?

<p>Two posterior glands (C)</p> Signup and view all the answers

Which breed of dogs might have an increased overall cancer risk associated with early-age ovariectomy?

<p>Golden Retrievers (C)</p> Signup and view all the answers

What type of mammary tumors are most common in cats?

<p>Adenocarcinomas (A)</p> Signup and view all the answers

At what age do cats experience a significant reduction in the risk of mammary carcinoma development if spayed?

<p>&lt; 6 months (D)</p> Signup and view all the answers

What is the primary site of metastasis for canine mammary tumors?

<p>Regional lymph nodes and lungs (A)</p> Signup and view all the answers

Which tumor type may contain grossly recognizable bone or cartilage on the cut surface?

<p>Mixed mammary tumors (C)</p> Signup and view all the answers

Which gland is more frequently involved in mammary tumors in cats compared to dogs?

<p>Anterior glands (D)</p> Signup and view all the answers

In cats, which factor does not affect feline mammary carcinoma development?

<p>Parity (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of feline mammary hypertrophy?

<p>Commonly diagnosed through thoracic radiographs (C)</p> Signup and view all the answers

Why are fine-needle aspirates considered a good diagnostic option for mammary tumors in dogs and cats?

<p>They are less invasive compared to histopathology (C)</p> Signup and view all the answers

What is the primary treatment option for mammary tumors in dogs and cats?

<p>Lumpectomy (D)</p> Signup and view all the answers

Which characteristic is NOT typically associated with malignant mammary tumors?

<p>Low nuclear-to-cytoplasmic ratio (C)</p> Signup and view all the answers

Why is there no consensus on the best surgical procedure for treating mammary tumors in dogs and cats?

<p>The wide variation in tumor types and locations (B)</p> Signup and view all the answers

Which factor makes evaluating the response to adjuvant chemotherapy difficult for canine mammary tumors?

<p>Half of the diagnosed malignant tumors do not behave as such (B)</p> Signup and view all the answers

What has been shown to potentiate G0/G1 arrest in cell cycle progression when used in conjunction with doxorubicin?

<p>Deracoxib (A)</p> Signup and view all the answers

Which imaging technique has moderate sensitivity and specificity to predict malignancy in neoplastic mammary tissue?

<p>Ultrasound elastography (B)</p> Signup and view all the answers

What is a distinguishing feature of feline mammary hypertrophy?

<p>Rapid growth of one or more mammary glands (C)</p> Signup and view all the answers

What is the role of Robinson's grading system in fine-needle aspirates?

<p>To evaluate cellular characteristics indicating malignancy (C)</p> Signup and view all the answers

What characteristic is NOT helpful in predicting malignancy using B-mode and Doppler ultrasonography?

<p>Cellular pleomorphism (B)</p> Signup and view all the answers

Why is chemotherapy not considered an effective treatment for mammary tumors in dogs?

<p>Chemotherapy has not shown survival benefits in dogs (D)</p> Signup and view all the answers

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