Podcast
Questions and Answers
What happens to the frequency of naive T cells specific for an antigen after antigen exposure?
What happens to the frequency of naive T cells specific for an antigen after antigen exposure?
- It increases to 1 in 3 CD8+ T cells and 1 in 100 CD4+ T cells (correct)
- It decreases significantly
- It increases to 1 in 10 CD8+ T cells and 1 in 50 CD4+ T cells
- It remains the same
What do effector CD4+ cells do?
What do effector CD4+ cells do?
- Do not participate in immune responses
- Express surface molecules and secrete cytokines that activate other cells (correct)
- Secrete cytokines that kill infected cells
- Express surface molecules to inactivate other cells
What is the function of effector CD8+ cells?
What is the function of effector CD8+ cells?
- Act as memory cells
- Help in the differentiation of naive T cells
- Kill infected cells (correct)
- Secrete cytokines to activate other immune cells
What is the result of T cell-mediated immune responses to an antigen?
What is the result of T cell-mediated immune responses to an antigen?
What is the significance of Edward Jenner's classic smallpox vaccination experiment?
What is the significance of Edward Jenner's classic smallpox vaccination experiment?
What is the key feature of clonal expansion of lymphocytes?
What is the key feature of clonal expansion of lymphocytes?
What is responsible for the prolonged survival of memory T cells?
What is responsible for the prolonged survival of memory T cells?
What allows memory T cells to respond more rapidly to antigen stimulation than naive cells specific for the same antigen?
What allows memory T cells to respond more rapidly to antigen stimulation than naive cells specific for the same antigen?
How do memory T cells contribute to the immune system's homeostasis?
How do memory T cells contribute to the immune system's homeostasis?
Which factor triggers apoptosis of T cells leading to the decline of T cell responses?
Which factor triggers apoptosis of T cells leading to the decline of T cell responses?
What is the main reason for the contraction of the T cell response upon elimination of antigen?
What is the main reason for the contraction of the T cell response upon elimination of antigen?
Which statement about memory T cells is accurate?
Which statement about memory T cells is accurate?
What technology is utilized in Yescarta therapy for treating certain types of large B-cell lymphoma?
What technology is utilized in Yescarta therapy for treating certain types of large B-cell lymphoma?
Where do dendritic cells capture protein antigens to initiate T-cell responses?
Where do dendritic cells capture protein antigens to initiate T-cell responses?
What is the role of CD28:B7 interaction in T cell activation?
What is the role of CD28:B7 interaction in T cell activation?
Which receptor, when engaged, influences the balance of T cell activation by acting as an inhibitory receptor?
Which receptor, when engaged, influences the balance of T cell activation by acting as an inhibitory receptor?
How does the 2nd signal(s) for T cell activation work in conjunction with antigen recognition?
How does the 2nd signal(s) for T cell activation work in conjunction with antigen recognition?
What is the primary function of CTLA-4 in relation to T cell activation?
What is the primary function of CTLA-4 in relation to T cell activation?
Which therapy is approved for the treatment of rheumatoid arthritis and transplant rejection by targeting costimulation pathways?
Which therapy is approved for the treatment of rheumatoid arthritis and transplant rejection by targeting costimulation pathways?
Which interaction is critical for helper T cell-dependent antibody responses during T cell activation?
Which interaction is critical for helper T cell-dependent antibody responses during T cell activation?
Which surface molecule is commonly referred to as IL-2Rα?
Which surface molecule is commonly referred to as IL-2Rα?
Which cell type primarily produces IL-2 early after antigen recognition and co-stimulation?
Which cell type primarily produces IL-2 early after antigen recognition and co-stimulation?
What is the main function of IL-2 in T cell activation?
What is the main function of IL-2 in T cell activation?
Which of the following cytokines is not influenced by IL-2 production?
Which of the following cytokines is not influenced by IL-2 production?
What is the process known as when T cells undergo rapid proliferation resulting in an increased number of antigen-specific clones?
What is the process known as when T cells undergo rapid proliferation resulting in an increased number of antigen-specific clones?
Which of the following best describes the function of regulatory T cells in relation to IL-2?
Which of the following best describes the function of regulatory T cells in relation to IL-2?
What is a key characteristic of memory T cells that allows them to respond more rapidly to antigen stimulation than naive cells specific for the same antigen?
What is a key characteristic of memory T cells that allows them to respond more rapidly to antigen stimulation than naive cells specific for the same antigen?
Which protein is responsible for triggering apoptosis of T cells and contributes to the decline of T cell responses?
Which protein is responsible for triggering apoptosis of T cells and contributes to the decline of T cell responses?
What is the main factor that contributes to the prolonged survival of memory T cells?
What is the main factor that contributes to the prolonged survival of memory T cells?
Which cytokine is crucial for the maintenance of memory T cells but does not require constant antigen recognition?
Which cytokine is crucial for the maintenance of memory T cells but does not require constant antigen recognition?
What happens to the number of memory T cells specific for an antigen compared to the number of naive cells specific for the same antigen?
What happens to the number of memory T cells specific for an antigen compared to the number of naive cells specific for the same antigen?
Which characteristic distinguishes memory T cells from naive T cells in their ability to respond to antigens at peripheral tissues?
Which characteristic distinguishes memory T cells from naive T cells in their ability to respond to antigens at peripheral tissues?
Which cell type is primarily responsible for the production of IL-2 early after antigen recognition and co-stimulation?
Which cell type is primarily responsible for the production of IL-2 early after antigen recognition and co-stimulation?
What is the approximate frequency of naive T cells specific for any antigen before antigen exposure?
What is the approximate frequency of naive T cells specific for any antigen before antigen exposure?
Which type of cells do effector CD8+ cells primarily target and kill?
Which type of cells do effector CD8+ cells primarily target and kill?
What is the primary role of memory T cells in the immune system?
What is the primary role of memory T cells in the immune system?
What is the outcome of T cell-mediated immune responses to an antigen?
What is the outcome of T cell-mediated immune responses to an antigen?
Which cell type is primarily responsible for capturing protein antigens to initiate T-cell responses?
Which cell type is primarily responsible for capturing protein antigens to initiate T-cell responses?
Which surface molecule is expressed by T cells after activation and functions as a receptor for IL-2?
Which surface molecule is expressed by T cells after activation and functions as a receptor for IL-2?
What is the primary function of IL-2 in T cell activation?
What is the primary function of IL-2 in T cell activation?
Which of the following surface molecules is an inhibitory receptor that influences the balance of T cell activation?
Which of the following surface molecules is an inhibitory receptor that influences the balance of T cell activation?
What is the main reason for the contraction of the T cell response upon elimination of antigen?
What is the main reason for the contraction of the T cell response upon elimination of antigen?
Which interaction is critical for helper T cell-dependent antibody responses during T cell activation?
Which interaction is critical for helper T cell-dependent antibody responses during T cell activation?
What is the role of the 2nd signal(s) for T cell activation in conjunction with antigen recognition?
What is the role of the 2nd signal(s) for T cell activation in conjunction with antigen recognition?
What is the role of dendritic cells in initiating T-cell responses?
What is the role of dendritic cells in initiating T-cell responses?
What is the primary function of CTLA-4 in relation to T cell activation?
What is the primary function of CTLA-4 in relation to T cell activation?
What technology is utilized in Yescarta therapy for treating certain types of large B-cell lymphoma?
What technology is utilized in Yescarta therapy for treating certain types of large B-cell lymphoma?
What is the main function of IL-2 in T cell activation?
What is the main function of IL-2 in T cell activation?
What interaction is critical for helper T cell-dependent antibody responses during T cell activation?
What interaction is critical for helper T cell-dependent antibody responses during T cell activation?
What is the primary function of CD28 in T cell activation?
What is the primary function of CD28 in T cell activation?
What is the main reason for the contraction of the T cell response upon elimination of antigen?
What is the main reason for the contraction of the T cell response upon elimination of antigen?
Which cell type primarily produces IL-2 early after antigen recognition and co-stimulation?
Which cell type primarily produces IL-2 early after antigen recognition and co-stimulation?
What is responsible for the prolonged survival of memory T cells?
What is responsible for the prolonged survival of memory T cells?
What is the function of effector CD8+ cells?
What is the function of effector CD8+ cells?
Flashcards
What happens to the frequency of T cells after antigen exposure?
What happens to the frequency of T cells after antigen exposure?
naive T cells specific for an antigen increase to 1 in 3 CD8+ T cells and 1 in 100 CD4+ T cells.
What do effector CD4+ cells do?
What do effector CD4+ cells do?
Express surface molecules and secrete cytokines that activate other cells.
What is the function of effector CD8+ cells?
What is the function of effector CD8+ cells?
Kill infected cells.
What is the significance of Edward Jenner's smallpox vaccination experiment?
What is the significance of Edward Jenner's smallpox vaccination experiment?
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What is the key feature of clonal expansion of lymphocytes?
What is the key feature of clonal expansion of lymphocytes?
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What is responsible for the prolonged survival of memory T cells?
What is responsible for the prolonged survival of memory T cells?
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What allows memory T cells to respond more rapidly to antigen stimulation than naive cells specific for the same antigen?
What allows memory T cells to respond more rapidly to antigen stimulation than naive cells specific for the same antigen?
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How do memory T cells contribute to the immune system's homeostasis?
How do memory T cells contribute to the immune system's homeostasis?
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Which factor triggers apoptosis of T cells leading to the decline of T cell responses?
Which factor triggers apoptosis of T cells leading to the decline of T cell responses?
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What is the main reason for the contraction of the T cell response upon elimination of antigen?
What is the main reason for the contraction of the T cell response upon elimination of antigen?
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Which statement about memory T cells is accurate?
Which statement about memory T cells is accurate?
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What technology is utilized in Yescarta therapy for treating certain types of large B-cell lymphoma?
What technology is utilized in Yescarta therapy for treating certain types of large B-cell lymphoma?
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Where do dendritic cells capture protein antigens to initiate T-cell responses?
Where do dendritic cells capture protein antigens to initiate T-cell responses?
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What is the role of CD28:B7 interaction in T cell activation?
What is the role of CD28:B7 interaction in T cell activation?
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Which receptor, when engaged, influences the balance of T cell activation acting as an inhibitory receptor?
Which receptor, when engaged, influences the balance of T cell activation acting as an inhibitory receptor?
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How does the 2nd signal(s) for T cell activation work in conjunction with antigen recognition?
How does the 2nd signal(s) for T cell activation work in conjunction with antigen recognition?
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What is the primary function of CTLA-4 in relation to T cell activation?
What is the primary function of CTLA-4 in relation to T cell activation?
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Which therapy is approved for the treatment of rheumatoid arthritis and transplant rejection by targeting costimulation pathways?
Which therapy is approved for the treatment of rheumatoid arthritis and transplant rejection by targeting costimulation pathways?
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Which interaction is critical for helper T cell-dependent antibody responses during T cell activation?
Which interaction is critical for helper T cell-dependent antibody responses during T cell activation?
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Which surface molecule is commonly referred to as IL-2Rα?
Which surface molecule is commonly referred to as IL-2Rα?
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Which cell type primarily produces IL-2 early after antigen recognition and co-stimulation?
Which cell type primarily produces IL-2 early after antigen recognition and co-stimulation?
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What is the main function of IL-2 in T cell activation?
What is the main function of IL-2 in T cell activation?
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Which of the following cytokines is not influenced by IL-2 production?
Which of the following cytokines is not influenced by IL-2 production?
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What is the process known as when T cells undergo rapid proliferation resulting in an increased number of antigen-specific clones?
What is the process known as when T cells undergo rapid proliferation resulting in an increased number of antigen-specific clones?
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Which of the following best describes the function of regulatory T cells in relation to IL-2?
Which of the following best describes the function of regulatory T cells in relation to IL-2?
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What is a key characteristic of memory T cells that allows them to respond more rapidly to antigen stimulation than naive cells specific for the same antigen?
What is a key characteristic of memory T cells that allows them to respond more rapidly to antigen stimulation than naive cells specific for the same antigen?
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Which protein is responsible for triggering apoptosis of T cells and contributes to the decline of T cell responses?
Which protein is responsible for triggering apoptosis of T cells and contributes to the decline of T cell responses?
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What is the main factor that contributes to the prolonged survival of memory T cells?
What is the main factor that contributes to the prolonged survival of memory T cells?
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Which cytokine is crucial for the maintenance of memory T cells but does not require constant antigen recognition?
Which cytokine is crucial for the maintenance of memory T cells but does not require constant antigen recognition?
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What happens to the number of memory T cells specific for an antigen compared to the number of naive cells specific for the same antigen?
What happens to the number of memory T cells specific for an antigen compared to the number of naive cells specific for the same antigen?
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Which characteristic distinguishes memory T cells from naive T cells in their ability to respond to antigens at peripheral tissues?
Which characteristic distinguishes memory T cells from naive T cells in their ability to respond to antigens at peripheral tissues?
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Which cell type is primarily responsible for the production of IL-2 early after antigen recognition and co-stimulation?
Which cell type is primarily responsible for the production of IL-2 early after antigen recognition and co-stimulation?
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What is the approximate frequency of naive T cells specific for any antigen before antigen exposure?
What is the approximate frequency of naive T cells specific for any antigen before antigen exposure?
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Which type of cells do effector CD8+ cells primarily target and kill?
Which type of cells do effector CD8+ cells primarily target and kill?
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What is the primary role of memory T cells in the immune system?
What is the primary role of memory T cells in the immune system?
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What is the outcome of T cell-mediated immune responses to an antigen?
What is the outcome of T cell-mediated immune responses to an antigen?
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Which cell type is primarily responsible for capturing protein antigens to initiate T-cell responses?
Which cell type is primarily responsible for capturing protein antigens to initiate T-cell responses?
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Which surface molecule is expressed by T cells after activation and functions as a receptor for IL-2?
Which surface molecule is expressed by T cells after activation and functions as a receptor for IL-2?
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What is the primary function of IL-2 in T cell activation?
What is the primary function of IL-2 in T cell activation?
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Which of the following surface molecules is an inhibitory receptor that influences the balance of T cell activation?
Which of the following surface molecules is an inhibitory receptor that influences the balance of T cell activation?
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What is the main reason for the contraction of the T cell response upon elimination of antigen?
What is the main reason for the contraction of the T cell response upon elimination of antigen?
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Which interaction is critical for helper T cell-dependent antibody responses during T cell activation?
Which interaction is critical for helper T cell-dependent antibody responses during T cell activation?
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What is the role of the 2nd signal(s) for T cell activation in conjunction with antigen recognition?
What is the role of the 2nd signal(s) for T cell activation in conjunction with antigen recognition?
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What is the role of dendritic cells in initiating T-cell responses?
What is the role of dendritic cells in initiating T-cell responses?
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What is the primary function of CTLA-4 in relation to T cell activation?
What is the primary function of CTLA-4 in relation to T cell activation?
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What technology is utilized in Yescarta therapy for treating certain types of large B-cell lymphoma?
What technology is utilized in Yescarta therapy for treating certain types of large B-cell lymphoma?
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What is the main function of IL-2 in T cell activation?
What is the main function of IL-2 in T cell activation?
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What interaction is critical for helper T cell-dependent antibody responses during T cell activation?
What interaction is critical for helper T cell-dependent antibody responses during T cell activation?
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What is the primary function of CD28 in T cell activation?
What is the primary function of CD28 in T cell activation?
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