Podcast
Questions and Answers
What is the primary concern related to the differentiation of iPS cells?
What is the primary concern related to the differentiation of iPS cells?
What method has been suggested to circumvent the ethical roadblocks in stem cell research?
What method has been suggested to circumvent the ethical roadblocks in stem cell research?
Which model predicts how iPS cells can be generated?
Which model predicts how iPS cells can be generated?
What has emerged due to the Bush administration's restrictions on federal funding for ESC research?
What has emerged due to the Bush administration's restrictions on federal funding for ESC research?
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What remains a concern with the clinical application of iPS cells?
What remains a concern with the clinical application of iPS cells?
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What unique ethical issues are associated with iPS cells?
What unique ethical issues are associated with iPS cells?
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Which of the following ethical issues is no longer considered a major obstacle in iPS cell research?
Which of the following ethical issues is no longer considered a major obstacle in iPS cell research?
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What is the potential benefit highlighted regarding the research from ESC discoveries?
What is the potential benefit highlighted regarding the research from ESC discoveries?
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What significant approval did the FDA give in March 2009 regarding stem cell therapy?
What significant approval did the FDA give in March 2009 regarding stem cell therapy?
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How may induced pluripotent stem (IPS) cells impact the ethical debate surrounding stem cell research?
How may induced pluripotent stem (IPS) cells impact the ethical debate surrounding stem cell research?
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What characteristic distinguishes embryonic stem cells (ESCs) from totipotent stem cells?
What characteristic distinguishes embryonic stem cells (ESCs) from totipotent stem cells?
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What is a notable challenge associated with the advancement of stem cell research according to the content?
What is a notable challenge associated with the advancement of stem cell research according to the content?
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What does the approval of ESC-derived therapies represent in the context of stem cell research?
What does the approval of ESC-derived therapies represent in the context of stem cell research?
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Which attribute of ESCs is emphasized in the content regarding their classification?
Which attribute of ESCs is emphasized in the content regarding their classification?
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What role does law and policy play in the advancement of scientific innovation in stem cell research?
What role does law and policy play in the advancement of scientific innovation in stem cell research?
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What potential future development is suggested for induced pluripotent stem cells (IPS)?
What potential future development is suggested for induced pluripotent stem cells (IPS)?
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What was a significant outcome of Obama's approach to ESC research?
What was a significant outcome of Obama's approach to ESC research?
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Which statement best reflects the status of federal funding for ESC research?
Which statement best reflects the status of federal funding for ESC research?
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Which guideline is referred to as the 'industry standard' for ESC research?
Which guideline is referred to as the 'industry standard' for ESC research?
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What challenge do IRBs face in relation to ESC research?
What challenge do IRBs face in relation to ESC research?
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What does the regulatory framework assure about the treatment of donors?
What does the regulatory framework assure about the treatment of donors?
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What is a potential issue with the existing guidelines for ESC research?
What is a potential issue with the existing guidelines for ESC research?
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What role does the federal common rule play in ESC research?
What role does the federal common rule play in ESC research?
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Why is there a need for regulation of ESC research?
Why is there a need for regulation of ESC research?
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What is the primary reason for the resistance to paying women for egg donations used in research?
What is the primary reason for the resistance to paying women for egg donations used in research?
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What is an ESCRO in the context of embryonic stem cell research?
What is an ESCRO in the context of embryonic stem cell research?
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Why did the NAS recommend against payments beyond transportation expenses for egg donors in 2005?
Why did the NAS recommend against payments beyond transportation expenses for egg donors in 2005?
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What does the term 'significant bodily intrusion' refer to in the context of egg donation?
What does the term 'significant bodily intrusion' refer to in the context of egg donation?
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What was one of the arguments for implementing ESCROs alongside IRBs?
What was one of the arguments for implementing ESCROs alongside IRBs?
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What role do IRBs typically play in relation to embryonic stem cell research?
What role do IRBs typically play in relation to embryonic stem cell research?
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Which of the following is a reason cited for the potential cost and delay caused by an additional layer of review in ESC research?
Which of the following is a reason cited for the potential cost and delay caused by an additional layer of review in ESC research?
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What is the reason for limiting the creation of new ESC lines?
What is the reason for limiting the creation of new ESC lines?
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What is suggested as a potential loss due to the Bush administration's funding policy?
What is suggested as a potential loss due to the Bush administration's funding policy?
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What type of line does the author claim symbolizes commitment to human life?
What type of line does the author claim symbolizes commitment to human life?
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What complication arises from the storage of frozen embryos according to the policy discussed?
What complication arises from the storage of frozen embryos according to the policy discussed?
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What was the impact of a freezer shutdown on the federally funded embryos?
What was the impact of a freezer shutdown on the federally funded embryos?
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What did the Director of the NIH testify regarding the funding policy?
What did the Director of the NIH testify regarding the funding policy?
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What symbolic issue does J. A. Robertson associate with embryo research?
What symbolic issue does J. A. Robertson associate with embryo research?
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What was a major concern regarding privately derived cell lines after the Bush announcement?
What was a major concern regarding privately derived cell lines after the Bush announcement?
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What aspect of the Bush policy did critics argue would be counterproductive for ESC science?
What aspect of the Bush policy did critics argue would be counterproductive for ESC science?
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Study Notes
FDA Approval and ESC Research
- In March 2009, the FDA approved its first clinical trial involving embryonic stem cell (ESC)-derived therapy for spinal cord injuries, marking a significant advancement in translating laboratory research into clinical applications.
- The development of induced pluripotent stem (iPS) cells offers potential non-embryonic alternatives to ESCs, which may reduce ethical concerns surrounding their use.
Controversies Surrounding ESCs
- ESCs are derived from the embryo, are not totipotent, but are pluripotent, capable of developing into various cell types in the body.
- The controversy over ESCs revolves around ethical concerns related to the creation and use of embryos, leading to complex political and social debates.
Regulatory Framework and Ethical Oversight
- While federal funding for ESC research has been contentious, there is widespread agreement on the necessity for robust regulatory oversight to protect the rights of embryo donors and ensure ethical practices in research.
- The National Academies of Sciences (NAS) established guidelines for ESC research, which became a standard for institutions receiving federal funding, promoting transparency and ethical conduct.
Embryonic Stem Cells Research Organizations (ESCROs)
- To address the ethical complexities of ESC research, ESCROs were introduced to complement Institutional Review Boards (IRBs), ensuring that specialized expertise is applied to ESC-related ethical issues.
- ESCROs operate alongside IRBs, providing necessary approvals for research involving ESCs to enhance oversight and public confidence.
iPS Cells and Ethical Considerations
- iPS cells can be obtained from various somatic cells and raise new ethical issues, particularly concerning the potential to derive human gametes.
- The ability to produce gametes from iPS cells could enable significant advancements in ESC research but may also complicate existing moral and ethical discussions.
Shifting Perspectives on Ethical Issues
- While initial ethical debates around ESC research were significant, increased familiarity with the technologies has begun to diminish their perceived impact on scientific progress.
- Ongoing discussions about the moral status of early embryos remain relevant but are no longer viewed as the primary barrier to innovation in stem cell research.
Conclusion: Future of ESC Research
- The evolving landscape of stem cell research suggests optimism regarding the translation of scientific discoveries into clinical benefits, despite potential ongoing ethical challenges.
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Description
This quiz explores the significance of the FDA's first approval of a clinical trial involving embryonic stem cells (ESCs) and the ethical controversies surrounding their use. Additionally, it covers the advancements made with induced pluripotent stem (iPS) cells and the regulatory framework governing stem cell research. Test your knowledge on the science, politics, and ethics related to ESCs.