Podcast
Questions and Answers
What is the main pathological change in fatty liver (steatosis)?
What is the main pathological change in fatty liver (steatosis)?
- Accumulation of fats inside liver cells leading to fibrotic changes (correct)
- Formation of new liver cells to accommodate excess fat
- Increase in liver cell metabolism due to excess fat intake
- Decrease in liver cell size due to excessive fat storage
What are the two main categories of causes for fatty liver?
What are the two main categories of causes for fatty liver?
- Overfeeding of CHO & Fats and inadequate hydration
- Synthesis of TAG and Overmobilization of fats from adipose tissues (correct)
- High carbohydrate diet and low protein intake
- Excessive alcohol consumption and genetic predisposition
What happens when the liver's capacity to synthesize VLDL is exceeded?
What happens when the liver's capacity to synthesize VLDL is exceeded?
- The liver starts producing excess bile
- The liver converts excess fat into glycogen
- Cholesterol levels increase in the liver
- Triacylglycerol accumulates leading to fatty liver (correct)
What effect does a high carbohydrate diet have on fatty acid synthesis?
What effect does a high carbohydrate diet have on fatty acid synthesis?
How does overfeeding of carbohydrates and fats contribute to fatty liver?
How does overfeeding of carbohydrates and fats contribute to fatty liver?
What is the main pathological change in fatty liver (steatosis)?
What is the main pathological change in fatty liver (steatosis)?
What effect does a high carbohydrate diet have on fatty acid synthesis?
What effect does a high carbohydrate diet have on fatty acid synthesis?
What are the two main categories of causes for fatty liver?
What are the two main categories of causes for fatty liver?
What happens when the liver's capacity to synthesize VLDL is exceeded?
What happens when the liver's capacity to synthesize VLDL is exceeded?
How does overfeeding of carbohydrates and fats contribute to fatty liver?
How does overfeeding of carbohydrates and fats contribute to fatty liver?
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Study Notes
Fatty Liver (Steatosis)
- The main pathological change in fatty liver (steatosis) is the accumulation of excess triglycerides in liver cells.
Causes of Fatty Liver
- Fatty liver has two main categories of causes:
- Nutritional: resulting from overconsumption of carbohydrates and fats
- Metabolic: resulting from disorders such as diabetes, obesity, and insulin resistance
VLDL Synthesis and Fatty Liver
- When the liver's capacity to synthesize very low-density lipoprotein (VLDL) is exceeded, excess triglycerides accumulate in the liver, contributing to fatty liver.
High Carbohydrate Diet and Fatty Acid Synthesis
- A high carbohydrate diet stimulates fatty acid synthesis in the liver, leading to an increase in triglyceride production and accumulation.
Overfeeding and Fatty Liver
- Overfeeding of carbohydrates and fats leads to fatty liver as the excess energy is converted to triglycerides, which are stored in the liver, causing its dysfunction.
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