Fatty Acid Transport into Mitochondria

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Questions and Answers

What is the suffix commonly used in the nomenclature of fatty acids?

  • -ene
  • -ic (correct)
  • -yne
  • -ane

What is the name of the C18 saturated fatty acid derived from the parent hydrocarbon Octadecane?

  • Octadecanoic Acid (correct)
  • Octadecadienoic Acid
  • Octadecenoic Acid
  • Octadecatrienoic Acid

Where do fatty acid molecules undergo breakdown to generate Acetyl-CoA for the Krebs Cycle?

  • Mitochondria and peroxisomes (correct)
  • Peroxisomes and cytoplasm
  • Endoplasmic reticulum and lysosomes
  • Golgi apparatus and nucleus

What is the primary source of fatty acids for oxidation?

<p>Diet and mobilization from cellular stores (C)</p> Signup and view all the answers

Where are fatty acids stored in the body?

<p>Adipocytes of adipose tissue (A)</p> Signup and view all the answers

What triggers the mobilization of fatty acids from stored triacylglycerols?

<p>Increase in energy demands (D)</p> Signup and view all the answers

What is the primary function of insulin in adipose tissue?

<p>To inhibit the mobilization of fat from adipose tissue (B)</p> Signup and view all the answers

Which enzyme is responsible for activating fatty acids in the cytoplasm?

<p>Fatty acyl-CoA ligase (D)</p> Signup and view all the answers

What is the net result of the fatty acid activation process?

<p>The consumption of 2 molar equivalents of ATP (D)</p> Signup and view all the answers

Where does the oxidation of fatty acids occur?

<p>In the mitochondria (B)</p> Signup and view all the answers

What is the intermediate molecule involved in the transport of fatty acyl-CoA into the mitochondria?

<p>Acyl-carnitine (A)</p> Signup and view all the answers

What is the function of carnitine acyltransferase II?

<p>To catalyze the regeneration of fatty acyl-CoA (A)</p> Signup and view all the answers

What is the consequence of high concentrations of acetyl CoA on β-oxidation?

<p>It inhibits β-oxidation (B)</p> Signup and view all the answers

What is the primary regulator of β-oxidation as a whole?

<p>Fatty acid availability (D)</p> Signup and view all the answers

How many moles of NADH are generated per round of β-oxidation?

<p>1 mole (B)</p> Signup and view all the answers

What happens to the NADH and FADH2 produced during β-oxidation?

<p>They enter the respiratory pathway for the production of ATP (B)</p> Signup and view all the answers

Why do fatty acids yield more energy per carbon atom than carbohydrates?

<p>Because fatty acids produce more ATP per carbon atom (A)</p> Signup and view all the answers

What is the net result of the oxidation of one mole of oleic acid?

<p>146 moles of ATP (D)</p> Signup and view all the answers

Which of the following drugs can inhibit carnitine acyltransferases?

<p>Tolbutamide (A)</p> Signup and view all the answers

Which group of inherited diseases impairs β-oxidation due to deficiencies in acyl-CoA dehydrogenases?

<p>Inherited diseases of acyl-CoA dehydrogenase deficiency (C)</p> Signup and view all the answers

Which deficiency is the most common form of acyl-CoA dehydrogenase deficiency?

<p>Medium Chain Acyl CoA Dehydrogenase Deficiency (B)</p> Signup and view all the answers

Excessive urinary excretion of which compounds is diagnostic of Medium Chain Acyl CoA Dehydrogenase Deficiency?

<p>Medium-chain dicarboxylic acids (A)</p> Signup and view all the answers

Which rare inherited disorder patients accumulate large quantities of phytanic acid?

<p>Refsum's disease (D)</p> Signup and view all the answers

Which dietary restriction can ameliorate the symptoms of Refsum's disease?

<p>Limit ruminant meat consumption (D)</p> Signup and view all the answers

What is the enzyme responsible for exchanging CoA for carnitine during the transport of fatty acids into the mitochondria?

<p>Carnitinepalmitoyltransferase I (B)</p> Signup and view all the answers

What is the product of Acyl-CoA dehydrogenation during the β-oxidation of fatty acids?

<p>Trans Δ 2- enoyl-CoA (D)</p> Signup and view all the answers

What catalyzes the hydration of the double bond to form L-3hydroxyacyl CoA in the β-oxidation process?

<p>Enoyl CoA hydratase (B)</p> Signup and view all the answers

Which enzyme is involved in the 2nd dehydrogenation step of β-oxidation, leading to the formation of a ketone?

<p>βhydroxyacyl CoA dehydrogenase (A)</p> Signup and view all the answers

What type of reaction is catalyzed by β-ketoacyl CoA thiolase during the formation of CoA in the β-oxidation pathway?

<p>Thiolysis (D)</p> Signup and view all the answers

What are the final products of β-oxidation of fatty acids?

<p>Acyl CoA and a long chain fatty acyl CoA (C)</p> Signup and view all the answers

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