BC Lipid Metabolism: Synthesis and Degradation

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Questions and Answers

Which organelle is responsible for the synthesis of fatty acids?

  • Endoplasmic reticulum
  • Mitochondria
  • Cytosol (correct)
  • Golgi apparatus

What is the end product of fatty acid biosynthesis?

  • Acetyl CoA
  • Palmitate (correct)
  • Malonyl CoA
  • Citrate

Which enzyme is responsible for the formation of malonyl CoA?

  • Acetyl CoA carboxylase (ACC) (correct)
  • Citrate Transport System
  • Fatty Acid Synthase (FAS)
  • NADPH

What is the function of the Citrate Transport System in fatty acid biosynthesis?

<p>Transport of Acetyl CoA into the cytosol (A)</p> Signup and view all the answers

Which molecule is required for the initiation of fatty acid biosynthesis?

<p>Acetyl CoA (D)</p> Signup and view all the answers

What is the main source of Acetyl CoA for fatty acid biosynthesis?

<p>Glycolysis (C)</p> Signup and view all the answers

What is the role of Fatty Acid Synthase (FAS) in fatty acid biosynthesis?

<p>Assembly of the fatty acid chain (B)</p> Signup and view all the answers

Which enzyme is responsible for the formation of Malonyl CoA from Acetyl CoA in fatty acid synthesis?

<p>Acetyl-CoA Carboxylase (B)</p> Signup and view all the answers

What is the major source of NADPH for fatty acid biosynthesis?

<p>Pentose Phosphate Pathway (PPP) (C)</p> Signup and view all the answers

Which enzyme is responsible for the synthesis of the fatty acid chain in mammalian cells?

<p>Fatty Acid Synthase (C)</p> Signup and view all the answers

Which subunit of Fatty Acid Synthase (FAS) contains a Phosphopantetheine prosthetic group?

<p>Acyl Carrier Protein (ACP) (D)</p> Signup and view all the answers

Which step in fatty acid synthesis is considered the committed step?

<p>Formation of Malonyl CoA from Acetyl CoA (C)</p> Signup and view all the answers

How many turns of the fatty acid synthesis cycle are required to synthesize a C16 palmitate?

<p>7 (B)</p> Signup and view all the answers

What is the net equation for fatty acid synthesis?

<p>Acetyl-CoA + Malonyl-CoA + ATP + NADPH + H+ -&gt; Palmitate + CoA + ADP + Pi + NADP+ + CO2 + H2O (A)</p> Signup and view all the answers

Which enzyme is responsible for the mobilization of fatty acids from triacylglycerols?

<p>Adipose triacylglycerol lipase (ATGL) (C)</p> Signup and view all the answers

Which organelle is primarily involved in the oxidation of fatty acids?

<p>Mitochondria (B)</p> Signup and view all the answers

Which carbon is oxidized through a series of reactions during fatty acid oxidation?

<p>Beta carbon (A)</p> Signup and view all the answers

Which pathway involves the sequential removal of 2 carbon units (Acetyl CoA) from the carboxyl terminal of fatty acids?

<p>Mitochondrial beta-oxidation (D)</p> Signup and view all the answers

Which pathway involves the oxidation of very long (17-26 carbon) fatty acids beginning in peroxisomes?

<p>Peroxisomal beta-oxidation (B)</p> Signup and view all the answers

Which pathway involves the oxidation of the carboxyl terminal carbon, releasing it as CO2?

<p>Alpha-oxidation (C)</p> Signup and view all the answers

Which pathway involves the oxidation of the omega carbon to form a dicarboxylic acid?

<p>Omega-oxidation (B)</p> Signup and view all the answers

Which statement is true about the storage of fatty acids compared to carbohydrates?

<p>Fatty acids are stored in a more reduced state than carbohydrates (A)</p> Signup and view all the answers

What is the primary source of energy in most organisms?

<p>Stored lipids (C)</p> Signup and view all the answers

Which enzyme is responsible for the synthesis of longer fatty acid chains in the ER or microsomes and in mitochondria?

<p>Microsomal Δ9 Desaturase (A)</p> Signup and view all the answers

Which of the following is true about the nomenclature of fatty acids?

<p>In mammals, double bonds can be introduced only up to the Δ9 position (B)</p> Signup and view all the answers

Which of the following is true about essential fatty acids?

<p>They must be obtained from plant sources (C)</p> Signup and view all the answers

Which enzyme is required for the synthesis of long chain polyunsaturated fatty acids in eukaryotes?

<p>Elongase (B)</p> Signup and view all the answers

What is the main factor regulating the rate of lipogenesis?

<p>Excess glucose (D)</p> Signup and view all the answers

What happens to fats during starvation or in diabetes patients?

<p>They are broken down into fatty acids for energy production (B)</p> Signup and view all the answers

What triggers the secretion of epinephrine and glucagon for the mobilization of fats from adipose tissues?

<p>Low energy/blood glucose (C)</p> Signup and view all the answers

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