BC Lipid Metabolism: Synthesis and Degradation
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Questions and Answers

Which organelle is responsible for the synthesis of fatty acids?

  • Endoplasmic reticulum
  • Mitochondria
  • Cytosol (correct)
  • Golgi apparatus
  • What is the end product of fatty acid biosynthesis?

  • Acetyl CoA
  • Palmitate (correct)
  • Malonyl CoA
  • Citrate
  • Which enzyme is responsible for the formation of malonyl CoA?

  • Acetyl CoA carboxylase (ACC) (correct)
  • Citrate Transport System
  • Fatty Acid Synthase (FAS)
  • NADPH
  • What is the function of the Citrate Transport System in fatty acid biosynthesis?

    <p>Transport of Acetyl CoA into the cytosol</p> Signup and view all the answers

    Which molecule is required for the initiation of fatty acid biosynthesis?

    <p>Acetyl CoA</p> Signup and view all the answers

    What is the main source of Acetyl CoA for fatty acid biosynthesis?

    <p>Glycolysis</p> Signup and view all the answers

    What is the role of Fatty Acid Synthase (FAS) in fatty acid biosynthesis?

    <p>Assembly of the fatty acid chain</p> Signup and view all the answers

    Which enzyme is responsible for the formation of Malonyl CoA from Acetyl CoA in fatty acid synthesis?

    <p>Acetyl-CoA Carboxylase</p> Signup and view all the answers

    What is the major source of NADPH for fatty acid biosynthesis?

    <p>Pentose Phosphate Pathway (PPP)</p> Signup and view all the answers

    Which enzyme is responsible for the synthesis of the fatty acid chain in mammalian cells?

    <p>Fatty Acid Synthase</p> Signup and view all the answers

    Which subunit of Fatty Acid Synthase (FAS) contains a Phosphopantetheine prosthetic group?

    <p>Acyl Carrier Protein (ACP)</p> Signup and view all the answers

    Which step in fatty acid synthesis is considered the committed step?

    <p>Formation of Malonyl CoA from Acetyl CoA</p> Signup and view all the answers

    How many turns of the fatty acid synthesis cycle are required to synthesize a C16 palmitate?

    <p>7</p> Signup and view all the answers

    What is the net equation for fatty acid synthesis?

    <p>Acetyl-CoA + Malonyl-CoA + ATP + NADPH + H+ -&gt; Palmitate + CoA + ADP + Pi + NADP+ + CO2 + H2O</p> Signup and view all the answers

    Which enzyme is responsible for the mobilization of fatty acids from triacylglycerols?

    <p>Adipose triacylglycerol lipase (ATGL)</p> Signup and view all the answers

    Which organelle is primarily involved in the oxidation of fatty acids?

    <p>Mitochondria</p> Signup and view all the answers

    Which carbon is oxidized through a series of reactions during fatty acid oxidation?

    <p>Beta carbon</p> Signup and view all the answers

    Which pathway involves the sequential removal of 2 carbon units (Acetyl CoA) from the carboxyl terminal of fatty acids?

    <p>Mitochondrial beta-oxidation</p> Signup and view all the answers

    Which pathway involves the oxidation of very long (17-26 carbon) fatty acids beginning in peroxisomes?

    <p>Peroxisomal beta-oxidation</p> Signup and view all the answers

    Which pathway involves the oxidation of the carboxyl terminal carbon, releasing it as CO2?

    <p>Alpha-oxidation</p> Signup and view all the answers

    Which pathway involves the oxidation of the omega carbon to form a dicarboxylic acid?

    <p>Omega-oxidation</p> Signup and view all the answers

    Which statement is true about the storage of fatty acids compared to carbohydrates?

    <p>Fatty acids are stored in a more reduced state than carbohydrates</p> Signup and view all the answers

    What is the primary source of energy in most organisms?

    <p>Stored lipids</p> Signup and view all the answers

    Which enzyme is responsible for the synthesis of longer fatty acid chains in the ER or microsomes and in mitochondria?

    <p>Microsomal Δ9 Desaturase</p> Signup and view all the answers

    Which of the following is true about the nomenclature of fatty acids?

    <p>In mammals, double bonds can be introduced only up to the Δ9 position</p> Signup and view all the answers

    Which of the following is true about essential fatty acids?

    <p>They must be obtained from plant sources</p> Signup and view all the answers

    Which enzyme is required for the synthesis of long chain polyunsaturated fatty acids in eukaryotes?

    <p>Elongase</p> Signup and view all the answers

    What is the main factor regulating the rate of lipogenesis?

    <p>Excess glucose</p> Signup and view all the answers

    What happens to fats during starvation or in diabetes patients?

    <p>They are broken down into fatty acids for energy production</p> Signup and view all the answers

    What triggers the secretion of epinephrine and glucagon for the mobilization of fats from adipose tissues?

    <p>Low energy/blood glucose</p> Signup and view all the answers

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