20 Questions
What is the main function of fatty acids stored in adipose tissue?
Provide concentrated stores of metabolic energy
Which step of β-oxidation involves the transfer of acyl CoA into mitochondria?
Transfer of acyl CoA into mitochondria by carnitine transport system
What is the energy yield from the complete oxidation of fatty acids to CO2 and H2O?
9 kcal/g fat
What drives the reaction forward in the activation of fatty acids to their co-enzyme A (CoA) derivative?
Hydrolysis of PPi and synthesis of ATP
Where does the β-oxidation pathway occur?
Mitochondria
Where does the beta oxidation of fatty acids take place?
Mitochondria
Which molecule is used as a transporter for the transfer of fatty acids across the inner mitochondrial membrane?
Carnitine
Which enzyme transfers the fatty acyl group to the hydroxyl group of carnitine to form acyl carnitine?
Carnitine acyl transferase-I (CAT-I)
How is carnitine synthesized in the body?
From lysine and methionine
What is the final product after the successive removal of 2-carbon units in beta-oxidation of odd chain fatty acids?
Propionyl CoA
What is the role of carnitine in the beta-oxidation of fatty acids?
Transferring the fatty acyl group to form acyl carnitine
Which enzyme catalyzes the cleavage of beta-keto fatty acyl CoA, splitting off a molecule of acetyl CoA?
Thiolase
What is the precursor for the synthesis of carnitine in the body?
Lysine
Which molecule is involved in the transfer of fatty acids across the inner mitochondrial membrane?
Carnitine
What is the energy yield from the complete oxidation of fatty acids to CO2 and H2O?
9 kcal/g fat
What is the final product after the successive removal of 2-carbon units in beta-oxidation of odd chain fatty acids?
Propionyl CoA
In which organelle does the β-oxidation pathway occur?
Mitochondria
What drives the reaction forward in the activation of fatty acids to their co-enzyme A (CoA) derivative?
Energy from hydrolysis of PPi
What is the function of carnitine in the transfer of acyl CoA into mitochondria?
Facilitate transfer across inner mitochondrial membrane
What is the final product after the successive removal of 2-carbon units in beta-oxidation of fatty acids?
Acetyl-CoA
Test your knowledge of fatty acid metabolism enzymes and the role of carnitine in transporting long chain fatty acids into the mitochondria for beta oxidation. This quiz covers the activation of fatty acids, the involvement of acyl CoA dehydrogenases, and the function of thiophorase and carnitine in the process.
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