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Oxidation of the β carbon, catalyzed by acyl CoA dehydrogenase, generates trans-Δ2-enoyl CoA and FADH2.
Oxidation of the β carbon, catalyzed by acyl CoA dehydrogenase, generates trans-Δ2-enoyl CoA and FADH2.
step 1
Hydration of trans-Δ2-enoyl CoA by enoyl CoA hydratase yields l-3-hydroxyacyl CoA.
Hydration of trans-Δ2-enoyl CoA by enoyl CoA hydratase yields l-3-hydroxyacyl CoA.
step 2
Oxidation of l-3-hydroxyacyl CoA by l-3-hydroxyacyl CoA dehydrogenase generates 3-ketoacyl CoA and NADH.
Oxidation of l-3-hydroxyacyl CoA by l-3-hydroxyacyl CoA dehydrogenase generates 3-ketoacyl CoA and NADH.
step 3
Cleavage of the 3-ketoacyl CoA by β-ketothiolase forms acetyl CoA and a fatty acid chain two carbons shorter.
Cleavage of the 3-ketoacyl CoA by β-ketothiolase forms acetyl CoA and a fatty acid chain two carbons shorter.
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