Fatty Acid Degradation and Peroxisomes
16 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary source of fatty acids in the body?

  • Glycogen
  • Phospholipids
  • Triacylglycerols (correct)
  • Cholesterol
  • Before degradation, fatty acids are activated by acylation to which compound?

  • CoA (correct)
  • ATP
  • Carnitine
  • NADH
  • How many ATP equivalents are consumed during the activation of fatty acids?

  • 1
  • 2 (correct)
  • 4
  • 3
  • Where does beta-oxidation of fatty acids primarily occur?

    <p>Mitochondrial matrix</p> Signup and view all the answers

    Which molecule is responsible for transferring acyl groups during beta-oxidation?

    <p>Carnitine</p> Signup and view all the answers

    What is the main product generated from the degradation of acyl-CoA during beta-oxidation?

    <p>Acetyl-CoA</p> Signup and view all the answers

    What type of fatty acids yields propionyl-CoA upon oxidation?

    <p>Odd-chain fatty acids</p> Signup and view all the answers

    What drives the reaction for the activation of fatty acids?

    <p>ATP hydrolysis</p> Signup and view all the answers

    What enzyme is responsible for converting Methylmalonyl CoA to Succinyl CoA?

    <p>Methylmalonyl mutase</p> Signup and view all the answers

    Which statement is true regarding the energy yield from unsaturated fatty acids compared to saturated fatty acids?

    <p>Unsaturated fatty acids yield less energy.</p> Signup and view all the answers

    What is the role of NADPH in fatty acid oxidation?

    <p>Reducing equivalents supply</p> Signup and view all the answers

    Where does the oxidation of very long-chain fatty acids primarily occur?

    <p>Peroxisomes</p> Signup and view all the answers

    During the beta oxidation of fatty acids, which molecule is used to transport fatty acids into the mitochondria?

    <p>Carnitine</p> Signup and view all the answers

    Which of the following fatty acids undergoes chain shortening in the peroxisomes?

    <p>Very long-chain fatty acids</p> Signup and view all the answers

    What by-product is produced when electrons from very long-chain fatty acids are transferred directly to molecular oxygen?

    <p>Hydrogen peroxide</p> Signup and view all the answers

    In which cycle is Succinyl CoA involved?

    <p>TCA cycle</p> Signup and view all the answers

    Study Notes

    Fatty Acid Degradation

    • Fatty acids are the primary source of energy from triacylglycerols.

    • Fatty acids are activated before they are degraded, requiring two ATP equivalents.

    • Activated fatty acids are acylated to CoA, a process catalyzed by fatty acyl CoA synthetase.

    • Beta oxidation occurs in the mitochondrial matrix.

    • Acyl groups are transferred via carnitine.

    • Each round of beta oxidation consists of four reactions:

      • Oxidation (FAD)
      • Hydration
      • Oxidation (NAD+)
      • Thiolysis (CoA)
    • Beta oxidation results in the degradation of acyl-CoA into acetyl-CoA.

    • Odd-chain fatty acids yield propionyl-CoA.

    • Propionyl-CoA is converted to succinyl-CoA through a series of reactions:

      • Carboxylation to methylmalonyl-CoA
      • Isomerization by methylmalonyl mutase to succinyl-CoA
    • Unsaturated fatty acids yield less energy than saturated fatty acids because NADPH is used and QH2 is bypassed.

    Peroxisomes

    • Peroxisomes are involved in the degradation of very long chain fatty acids and branched-chain fatty acids.

    • Very long chain fatty acids undergo chain shortening in peroxisomes.

    • Electrons are transferred directly to molecular oxygen in peroxisomes, producing hydrogen peroxide (H2O2), which is broken down by catalase.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Lipid Metabolism II PDF

    Description

    Explore the mechanisms of fatty acid degradation, including β-oxidation, acyl-CoA activation, and the role of peroxisomes. Learn how different types of fatty acids yield varying energy levels and the biochemical pathways involved in converting propionyl-CoA to succinyl-CoA. This quiz will test your understanding of these key metabolic processes.

    More Like This

    Use Quizgecko on...
    Browser
    Browser