Fat Soluble Vitamins Overview

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Questions and Answers

What is a common side effect of antibiotics that could indicate a superinfection?

  • Weight gain
  • Chronic fatigue
  • Skin rash
  • Vaginal itching or discharge (correct)

What is the main purpose of ordering a culture and sensitivity test before starting antibiotic therapy?

  • To identify the patient's allergies
  • To assess the patient's kidney function
  • To determine the most cost-effective treatment
  • To determine the minimum inhibitory concentration of the drug needed (correct)

Which of the following medications is specifically indicated for treating urinary tract infections (UTIs)?

  • Amoxicillin
  • Vancomycin
  • Lisinopril
  • Ciprofloxacin (correct)

What is a significant concern when administering vancomycin to a patient?

<p>It can lead to renal failure if not monitored properly (C)</p> Signup and view all the answers

What side effect is commonly associated with high doses of niacin (B3) used to treat hyperlipidemia?

<p>Flushing and itching (B)</p> Signup and view all the answers

Which vitamin is crucial for blood clotting and can be an antidote for warfarin?

<p>Vitamin K (C)</p> Signup and view all the answers

What is the primary action of antiretroviral therapy in patients with HIV?

<p>To reduce the viral load and improve immune function (B)</p> Signup and view all the answers

What condition is associated with a deficiency in vitamin C?

<p>Scurvy (B)</p> Signup and view all the answers

Which B-vitamin is critical for preventing fetal neural tube defects?

<p>Folate (B9) (D)</p> Signup and view all the answers

What is a significant risk when taking iron supplements?

<p>Fatal toxicity in children (A)</p> Signup and view all the answers

What is the primary mechanism of action for antivirals?

<p>Prevent reproduction of viral DNA (D)</p> Signup and view all the answers

Which side effect is commonly associated with the use of vancomycin?

<p>Ototoxicity (B)</p> Signup and view all the answers

Which antibiotic is known for the side effect of orange discoloration of body fluids?

<p>Rifampin (A)</p> Signup and view all the answers

What is the typical dosage for vancomycin administration?

<p>1 gram (C)</p> Signup and view all the answers

Which of the following is a common side effect of trimethoprim-sulfamethoxazole?

<p>Crystalluria (B)</p> Signup and view all the answers

What is the recommended administration method for vancomycin to avoid red-man syndrome?

<p>IV infusion over 60-90 minutes (D)</p> Signup and view all the answers

Which antiviral medication is particularly effective against herpes simplex virus (HSV)?

<p>Acyclovir (D)</p> Signup and view all the answers

What is the primary use of nitrofurantoin?

<p>Treat acute urinary tract infections (A)</p> Signup and view all the answers

What is the main purpose of antiretroviral therapy for HIV patients?

<p>Reduce viral load (D)</p> Signup and view all the answers

Which of these is a precaution for patients on ganciclovir?

<p>Requires regular CBC monitoring (D)</p> Signup and view all the answers

What is a common assessment for a patient taking sulfonamides?

<p>Assess for allergy to sulfa drugs (C)</p> Signup and view all the answers

What is true about the dosing schedule of antiretroviral medications?

<p>Inconsistent dosing increases the risk of drug resistance (C)</p> Signup and view all the answers

What can be a side effect when combining rifampin with another anti-tuberculin medication?

<p>Increased risk of hepatotoxicity (A)</p> Signup and view all the answers

Flashcards

Prophylactic Therapy

Treatment given to prevent an infection, even if the patient doesn't have the infection.

Empiric Therapy

Treatment given when infection is suspected, using medications covering a wide range of possible pathogens.

Antituberculins (RIPE)

Medication used to treat tuberculosis infections. Includes Isoniazid (INH), Pyrazinamide, and Ethambutol.

INH MOA

Inhibits mycobacterial cell wall synthesis and interferes with metabolism, preventing replication and functioning.

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INH Side Effects

Peripheral neuropathy, hepatotoxicity, and hyperglycemia.

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Rifampin MOA

Bactericidal, killing bacteria.

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Rifampin Uses

Treats gram-negative and gram-positive bacteria, often combined with other anti-tuberculins to prevent resistance.

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Antivirals

Drugs that combat viral infections (e.g., herpes, influenza, hepatitis).

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Antiretrovirals

Medication used to treat HIV infection.

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HAART

Highly active antiretroviral therapy, using multiple drugs.

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Vancomycin Trough Levels

Blood levels measured just before the next dose to determine appropriate drug concentration.

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Vancomycin Uses

Treatment of staphylococcal infections and C.diff (oral dose).

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Vancomycin Narrow Therapeutic Index

Requires careful monitoring of blood levels to prevent toxicity.

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Sulfonamides/Trimethoprim Uses

Treats UTIs, otitis media, PCP, traveler's diarrhea, and shigella.

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Sulfonamides/Trimethoprim MOA

Bactericidal by inhibiting bacterial folic acid metabolism.

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Urinary Tract Antiseptics

Drugs used to treat and prevent urinary tract infections (UTIs).

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Tetracyclines

Antibiotics used for a variety of bacterial infections.

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Fat-soluble vitamins

Vitamins A, D, E, and K that are stored in the body and have a higher risk of toxicity.

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Vitamin A

Essential for vision, skeletal, and soft tissue health.

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Vitamin D compounds

Crucial for calcium absorption and bone health.

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Vitamin E

An antioxidant that protects cells from damage.

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Vitamin K

Essential for blood clotting and bone maintenance.

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Water-soluble vitamins

Vitamins that are not stored in the body and are eliminated through urine.

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Vitamin C

Important for tissue building, metabolism, and iron absorption.

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B-Complex vitamins

Essential for metabolism, energy, and nerve function.

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Thiamin (B1)

Crucial for preventing beriberi, a disease affecting nerves and heart.

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Niacin (B3)

Used to treat high cholesterol and important in preventing pellagra

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Riboflavin (B2)

Essential for preventing mouth and tongue problems.

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Folate (B9)

Essential to prevent birth defects and supports red blood cell production.

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Cobalamin (B12)

Treats pernicious anemia and vital for nerve cell function and red blood cell production.

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Pyridoxine (B6)

Important for nerve and brain health and also crucial to amino acid metabolism.

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Iron

Essential mineral for hemoglobin formation and oxygen transport.

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Iodine

Used to produce thyroid hormones.

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Fluoride

Protects teeth from cavities.

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Zinc

Plays a role in immune function.

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Study Notes

Fat Soluble Vitamins

  • Vitamins A, D, E, and K are stored in the body for a long time, posing a risk of toxicity.
  • Vitamin A is crucial for vision, skeletal and soft tissue development, and strength.
  • Food sources include orange/yellow fruits and vegetables, fatty fish, eggs, and dairy.
  • Deficiency can cause vision problems like xerophthalmia.
  • Vitamin D (calcitriol, ergocalciferol) is used to treat hypocalcemia and vitamin D deficiency.
  • Food sources include canned fish, cereals, and fortified milk.
  • Deficiency can cause rickets and osteomalacia.
  • Vitamin E (tocopherols) acts as an antioxidant, protecting cells.
  • Found in vegetable oils, nuts, whole grains, and dark green vegetables.
  • Deficiency is rare but can cause muscle pain, weakness, poor balance, and anemia.
  • Vitamin K (phytonadione) is essential for blood clotting and bone maintenance.
  • Sources include dark green vegetables, eggs, fish, and liver.
  • Deficiency leads to increased bleeding time.
  • Vitamin K assists in blood clotting and bone maintenance.

Water Soluble Vitamins

  • Vitamin C (ascorbic acid) facilitates tissue building, metabolism, and iron absorption.
  • It's found in citrus fruits, tomatoes, green leafy vegetables, and peppers.
  • Deficiency results in scurvy, with symptoms like bleeding, joint pain, and swollen gums.
  • Intake should be increased during stress or illness.
  • B-complex vitamins are involved in metabolism, energy, and nerve function.
  • Food sources include meats, milk, legumes, enriched grains, and green leafy vegetables.
  • Thiamin (B1) deficiency can cause beriberi, affecting nerves and the heart, and is commonly associated with alcohol abuse.
  • Niacin (B3) is another essential B vitamin.

Trace Minerals

  • Iron (ferrous sulfate, iron dextran) is a crucial component of hemoglobin and myoglobin.
  • It treats iron deficiency anemia.
  • Sources include meats, fish, grains, and legumes.
  • Iron supplements can cause gastrointestinal upset (constipation, stomach upset)
  • Caution with high doses, especially for children.
  • Iodine is essential for the synthesis of thyroxine, a thyroid hormone, found in table salt and seafood.
  • Fluoride strengthens teeth and prevents cavities, and is found in water.

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